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1993 1
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Page 1
Gonadotrophin receptors.
Clayton RN. Clayton RN. Baillieres Clin Endocrinol Metab. 1996 Jan;10(1):1-8. doi: 10.1016/s0950-351x(96)80250-3. Baillieres Clin Endocrinol Metab. 1996. PMID: 8734448 Review.
Precocious puberty may be gonadotrophin-dependent, due to premature activation of the hypothalamic GnRH pulse generator, or gonadotrophin-independent wherein serum LH and FSH levels are undetectable despite near-adult levels of gonadal steroidogenesis. In one form of gonadotrophi …
Precocious puberty may be gonadotrophin-dependent, due to premature activation of the hypothalamic GnRH pulse generator, or gonadotrophin-in …
Treatment of familial male precocious puberty with spironolactone, testolactone, and deslorelin.
Laue L, Jones J, Barnes KM, Cutler GB Jr. Laue L, et al. J Clin Endocrinol Metab. 1993 Jan;76(1):151-5. doi: 10.1210/jcem.76.1.8421081. J Clin Endocrinol Metab. 1993. PMID: 8421081 Clinical Trial.
Combined antiandrogen (spironolactone) and aromatase inhibitor (testolactone) are effective for the short term treatment of familial male precocious puberty. During this therapy, plasma testosterone levels remain in the adult range, since spironolacton …
Combined antiandrogen (spironolactone) and aromatase inhibitor (testolactone) are effective for the short term treatment of familial
Use of aromatase inhibitors in precocious puberty.
Feuillan P, Merke D, Leschek EW, Cutler GB Jr. Feuillan P, et al. Endocr Relat Cancer. 1999 Jun;6(2):303-6. doi: 10.1677/erc.0.0060303. Endocr Relat Cancer. 1999. PMID: 10731123 Review.
In a 6-month pilot study of 12 children (eight boys; four girls) with congenital adrenal hyperplasia, testolactone, in combination with an antiandrogen (flutamide), a mineralocorticoid (fludrocortisone acetate, Florinef), and a reduced glucocorticoid dose, improved the control of …
In a 6-month pilot study of 12 children (eight boys; four girls) with congenital adrenal hyperplasia, testolactone, in combination with an a …
Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans.
Cook JC, Klinefelter GR, Hardisty JF, Sharpe RM, Foster PM. Cook JC, et al. Crit Rev Toxicol. 1999 Mar;29(2):169-261. doi: 10.1080/10408449991349203. Crit Rev Toxicol. 1999. PMID: 10213111 Review.
This evidence includes the following: (1) the human incidence of LCTs is much lower than in rodents even when corrected for detection bias; (2) several comparative differences exist between rat and human LCs that may contribute, at least in part, to the greater susceptibility of …
This evidence includes the following: (1) the human incidence of LCTs is much lower than in rodents even when corrected for detection bias; …
Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty.
Mueller SC, Mandell D, Leschek EW, Pine DS, Merke DP, Ernst M. Mueller SC, et al. J Child Adolesc Psychopharmacol. 2009 Feb;19(1):41-50. doi: 10.1089/cap.2008.031. J Child Adolesc Psychopharmacol. 2009. PMID: 19232022 Free PMC article.
We used functional magnetic resonance imaging (fMRI) to examine emotional processing in familial male-precocious puberty (FMPP), an extremely rare gonadotropin-independent form of precocious puberty characterized by early excess testosterone secretion. …
We used functional magnetic resonance imaging (fMRI) to examine emotional processing in familial male-precocious pub
Psychiatric characterization of children with genetic causes of hyperandrogenism.
Mueller SC, Ng P, Sinaii N, Leschek EW, Green-Golan L, VanRyzin C, Ernst M, Merke DP. Mueller SC, et al. Eur J Endocrinol. 2010 Nov;163(5):801-10. doi: 10.1530/EJE-10-0693. Epub 2010 Aug 31. Eur J Endocrinol. 2010. PMID: 20807778 Free PMC article. Clinical Trial.
DESIGN/METHODS: Children (8-18 years) with the diagnosis of classic congenital adrenal hyperplasia (CAH) or familial male precocious puberty (FMPP) underwent a semi-structured psychiatric interview, the Kiddie Schedule for Affective Disorders and Schiz …
DESIGN/METHODS: Children (8-18 years) with the diagnosis of classic congenital adrenal hyperplasia (CAH) or familial male p
Body image in adolescents with disorders of steroidogenesis.
Ning C, Green-Golan L, Stratakis CA, Leschek E, Sinaii N, Schroth E, Ernst M, Merke DP. Ning C, et al. J Pediatr Endocrinol Metab. 2008 Aug;21(8):771-80. doi: 10.1515/jpem.2008.21.8.771. J Pediatr Endocrinol Metab. 2008. PMID: 18825877 Free PMC article.
We evaluated body image in children with congenital adrenal hyperplasia (CAH), familial male precocious puberty (FMPP), and Cushing's syndrome (CS). ...
We evaluated body image in children with congenital adrenal hyperplasia (CAH), familial male precocious puberty
Increased medial temporal lobe and striatal grey-matter volume in a rare disorder of androgen excess: a voxel-based morphometry (VBM) study.
Mueller SC, Merke DP, Leschek EW, Fromm S, VanRyzin C, Ernst M. Mueller SC, et al. Int J Neuropsychopharmacol. 2011 May;14(4):445-57. doi: 10.1017/S1461145710001136. Epub 2010 Sep 22. Int J Neuropsychopharmacol. 2011. PMID: 20860880 Free PMC article.
Using voxel-based morphometry (DARTEL), we compared MTL and striatal structures in 13 [mean age (S.D.) 12.73.2 yr, mean bone age 14.83.2 yr] boys with familial male precocious puberty (FMPP), characterized by early excess androgen secretion, and 39 hea …
Using voxel-based morphometry (DARTEL), we compared MTL and striatal structures in 13 [mean age (S.D.) 12.73.2 yr, mean bone age 14.83.2 yr] …
Long-term follow-up of spontaneous development in a boy with familial male precocious puberty.
Partsch CJ, Krone N, Riepe FG, Gromoll J, Sippell WG. Partsch CJ, et al. Horm Res. 2004;62(4):177-81. doi: 10.1159/000080887. Epub 2004 Sep 15. Horm Res. 2004. PMID: 15375328
BACKGROUND/AIMS: Limited data are available about spontaneous growth, pubertal growth spurt and the long-term outcome of patients suffering from familial male precocious puberty (FMPP). We report on a boy with FMPP whose growth pattern and pubertal dev …
BACKGROUND/AIMS: Limited data are available about spontaneous growth, pubertal growth spurt and the long-term outcome of patients suffering …
12 results