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1986 2
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Page 1
Familial hypoalphalipoproteinemia.
Glueck CJ, Melser MA, Borecki IB, Third JL, Rao DC, Laskarzewski PM. Glueck CJ, et al. Adv Exp Med Biol. 1986;201:83-92. doi: 10.1007/978-1-4684-1262-8_8. Adv Exp Med Biol. 1986. PMID: 3541525 Review. No abstract available.
Very low HDL levels: clinical assessment and management.
Bonilha I, Luchiari B, Nadruz W, Sposito AC. Bonilha I, et al. Arch Endocrinol Metab. 2023 Jan 18;67(1):3-18. doi: 10.20945/2359-3997000000585. Arch Endocrinol Metab. 2023. PMID: 36651718 Free PMC article. Review.
In individuals with very low high-density lipoprotein (HDL-C) cholesterol, such as Tangier disease, LCAT deficiency, and familial hypoalphalipoproteinemia, there is an increased risk of premature atherosclerosis. ...Trials that evaluated some of the HDL functions de …
In individuals with very low high-density lipoprotein (HDL-C) cholesterol, such as Tangier disease, LCAT deficiency, and familial …
Genetic determinants of plasma lipoproteins.
Pollex RL, Hegele RA. Pollex RL, et al. Nat Clin Pract Cardiovasc Med. 2007 Nov;4(11):600-9. doi: 10.1038/ncpcardio1005. Nat Clin Pract Cardiovasc Med. 2007. PMID: 17957207 Review.
Despite some exceptions, these efforts have not yet yielded a set of biological markers that can be used in clinical practice. By contrast, successes in defining the molecular basis of rare single-gene disorders, such as familial hypoalphalipoproteinemia, hav …
Despite some exceptions, these efforts have not yet yielded a set of biological markers that can be used in clinical practice. By con …
Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia.
Ordovas JM, Schaefer EJ, Salem D, Ward RH, Glueck CJ, Vergani C, Wilson PW, Karathanasis SK. Ordovas JM, et al. N Engl J Med. 1986 Mar 13;314(11):671-7. doi: 10.1056/NEJM198603133141102. N Engl J Med. 1986. PMID: 3081805
Within kindreds with familial hypoalphalipoproteinemia and among first-degree relatives of patients with coronary artery disease, the 3.3-kb band was associated with decreased HDL cholesterol levels. ...These findings indicate that the polymorphism in the region bet …
Within kindreds with familial hypoalphalipoproteinemia and among first-degree relatives of patients with coronary artery disea …
Familial lipoprotein disorders and premature coronary artery disease.
Schaefer EJ. Schaefer EJ. Med Clin North Am. 1994 Jan;78(1):21-39. doi: 10.1016/s0025-7125(16)30175-4. Med Clin North Am. 1994. PMID: 8283932 Review.
Although there is consensus that lipid variables, especially lipoprotein(a), are heritable and that elevated LDL cholesterol levels should be treated, there are no clear definitions of the common familial lipid disorders associated with premature CHD (lipoprotein(a) excess, FCH, …
Although there is consensus that lipid variables, especially lipoprotein(a), are heritable and that elevated LDL cholesterol levels should b …
No benefit of HDL mimetic CER-001 on carotid atherosclerosis in patients with genetically determined very low HDL levels.
Zheng KH, Kaiser Y, van Olden CC, Santos RD, Dasseux JL, Genest J, Gaudet D, Westerink J, Keyserling C, Verberne HJ, Leitersdorf E, Hegele RA, Descamps OS, Hopkins P, Nederveen AJ, Stroes ESG. Zheng KH, et al. Atherosclerosis. 2020 Oct;311:13-19. doi: 10.1016/j.atherosclerosis.2020.08.004. Epub 2020 Aug 29. Atherosclerosis. 2020. PMID: 32919280 Free article. Clinical Trial.
Patients with very low levels of HDL-cholesterol and impaired cholesterol efflux capacity can be expected to derive the most potential benefit from infusion of HDL mimetics. This randomized clinical trial evaluated the efficacy of infusions of the HDL mimetic …
Patients with very low levels of HDL-cholesterol and impaired cholesterol efflux capacity can be expected to derive the most potential benef …
Familial aggregation of lipids and lipoproteins in families ascertained through random and nonrandom probands in the Minnesota Lipid Research Clinic Family Study.
Rice T, Vogler GP, Laskarzewski PM, Perry TS, Rao DC. Rice T, et al. Hum Biol. 1991 Aug;63(4):419-39. Hum Biol. 1991. PMID: 1889794
However, for TG and HDL the random and hyperlipidemic samples are significantly heterogeneous. This heterogeneity would be observed if familial hypertriglyceridemia and/or familial hypoalphalipoproteinemia segregates predominantly in the hyperlipidemic rather …
However, for TG and HDL the random and hyperlipidemic samples are significantly heterogeneous. This heterogeneity would be observed i …
Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein.
Bisoendial RJ, Hovingh GK, Levels JH, Lerch PG, Andresen I, Hayden MR, Kastelein JJ, Stroes ES. Bisoendial RJ, et al. Circulation. 2003 Jun 17;107(23):2944-8. doi: 10.1161/01.CIR.0000070934.69310.1A. Epub 2003 May 27. Circulation. 2003. PMID: 12771001 Clinical Trial.
BACKGROUND: Loss-of-function mutations in the ATP-binding cassette (ABCA)-1 gene locus are the underlying cause for familial hypoalphalipoproteinemia, providing a human isolated low-HDL model. In these familial hypoalphalipoproteinemia subjects, we eva …
BACKGROUND: Loss-of-function mutations in the ATP-binding cassette (ABCA)-1 gene locus are the underlying cause for familial hypoa …
Treatment of low HDL-C subjects with the CETP modulator dalcetrapib increases plasma campesterol only in those without ABCA1 and/or ApoA1 mutations.
Niesor EJ, Kallend D, Bentley D, Kastelein JJ, Kees Hovingh G, Stroes ES. Niesor EJ, et al. Lipids. 2014 Dec;49(12):1245-9. doi: 10.1007/s11745-014-3956-x. Epub 2014 Oct 4. Lipids. 2014. PMID: 25281277 Clinical Trial.
We investigated the effect of dalcetrapib treatment on phytosterol levels in patients with familial combined hyperlipidemia (FCH) or familial hypoalphalipoproteinemia (FHA) due to mutations in apolipoprotein A1 (ApoA1) or ATP-binding cassette transporter A1 (ABCA1). …
We investigated the effect of dalcetrapib treatment on phytosterol levels in patients with familial combined hyperlipidemia (FCH) or fami …
Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA.
Kootte RS, Smits LP, van der Valk FM, Dasseux JL, Keyserling CH, Barbaras R, Paolini JF, Santos RD, van Dijk TH, Dallinga-van Thie GM, Nederveen AJ, Mulder WM, Hovingh GK, Kastelein JP, Groen AK, Stroes E. Kootte RS, et al. J Lipid Res. 2015 Mar;56(3):703-712. doi: 10.1194/jlr.M055665. Epub 2015 Jan 5. J Lipid Res. 2015. PMID: 25561459 Free PMC article. Clinical Trial.
Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with the orphan disease, familial hypoalphalipoproteinemia (FHA), are characterized by decreased tissue cholesterol removal and an increased atherogenic burden. ...
Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with the orphan disease, familial …
11 results