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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1987 1
1988 1
1989 3
1990 6
1991 7
1992 3
1993 6
1994 2
1995 1
1996 5
1997 4
1998 9
1999 9
2000 15
2001 22
2002 18
2003 28
2004 30
2005 48
2006 54
2007 59
2008 68
2009 70
2010 71
2011 97
2012 82
2013 87
2014 103
2015 95
2016 86
2017 94
2018 103
2019 86
2020 84
2021 72
2022 66
2023 78
2024 32

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1,518 results

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Page 1
Effects of fasudil on pulmonary hypertension in clinical practice.
Zhang Y, Wu S. Zhang Y, et al. Pulm Pharmacol Ther. 2017 Oct;46:54-63. doi: 10.1016/j.pupt.2017.08.002. Epub 2017 Aug 4. Pulm Pharmacol Ther. 2017. PMID: 28782712 Review.
Because Rho-kinase (ROCK) plays an important role in the pathogenesis of PH, the ROCK inhibitor fasudil is expected to contribute to PH treatment. In animal models of PH, fasudil reduced pulmonary artery pressure (PAP) and improved survival. ...According to animal s …
Because Rho-kinase (ROCK) plays an important role in the pathogenesis of PH, the ROCK inhibitor fasudil is expected to contribute to …
Fasudil alleviates the vascular endothelial dysfunction and several phenotypes of Fabry disease.
Choi JB, Seol DW, Do HS, Yang HY, Kim TM, Byun YG, Park JM, Choi J, Hong SP, Chung WS, Suh JM, Koh GY, Lee BH, Wee G, Han YM. Choi JB, et al. Mol Ther. 2023 Apr 5;31(4):1002-1016. doi: 10.1016/j.ymthe.2023.02.003. Epub 2023 Feb 8. Mol Ther. 2023. PMID: 36755495 Free PMC article.
Furthermore, fasudil downregulated the endothelial-to-mesenchymal transition (EndMT) and mitochondrial function of FD-VECs. ...Our findings demonstrate that fasudil is a novel candidate for FD therapy....
Furthermore, fasudil downregulated the endothelial-to-mesenchymal transition (EndMT) and mitochondrial function of FD-VECs. ...Our fi …
Fasudil inhibits the expression of C/EBP homologous protein to protect against liver injury in acetaminophen-overdosed mice.
Namba N, Kuwahara T, Kondo Y, Fukusaki K, Miyata K, Oike Y, Irie T, Ishitsuka Y. Namba N, et al. Biochem Biophys Res Commun. 2023 Dec 17;686:149166. doi: 10.1016/j.bbrc.2023.149166. Epub 2023 Oct 26. Biochem Biophys Res Commun. 2023. PMID: 37931363
Acetaminophen (APAP) overdoses can cause severe liver injury. In this study, the protective effect of fasudil against APAP-induced liver injury was investigated. APAP (400 mg/kg) was administered to male C57BL/6J mice to induce liver injury, and fasudil (20 or 40 mg …
Acetaminophen (APAP) overdoses can cause severe liver injury. In this study, the protective effect of fasudil against APAP-induced li …
Effects of fasudil on blood-brain barrier integrity.
Sato K, Nakagawa S, Morofuji Y, Matsunaga Y, Fujimoto T, Watanabe D, Izumo T, Niwa M, Walter FR, Vigh JP, Santa-Maria AR, Deli MA, Matsuo T. Sato K, et al. Fluids Barriers CNS. 2022 Jun 3;19(1):43. doi: 10.1186/s12987-022-00336-w. Fluids Barriers CNS. 2022. PMID: 35659272 Free PMC article.
RESULTS: We found that treatment with 0.3-30 M of fasudil increased cellular impedance. Fasudil enhanced barrier properties in a concentration-dependent manner, as measured by an increased (TEER) and decreased permeability. Fasudil also increased the expressi …
RESULTS: We found that treatment with 0.3-30 M of fasudil increased cellular impedance. Fasudil enhanced barrier properties in …
Fasudil Ameliorates Methotrexate-Induced Hepatotoxicity by Modulation of Redox-Sensitive Signals.
Aboubakr EM, Ibrahim ARN, Ali FEM, Mourad AAE, Ahmad AM, Hofni A. Aboubakr EM, et al. Pharmaceuticals (Basel). 2022 Nov 19;15(11):1436. doi: 10.3390/ph15111436. Pharmaceuticals (Basel). 2022. PMID: 36422565 Free PMC article.
Furthermore, fasudil hepatic concentration was determined for the first time using the validated RP-HPLC method. ...It also introduced a new method for the determination of fasudil hepatic tissue concentration using the RP-HPLC technique....
Furthermore, fasudil hepatic concentration was determined for the first time using the validated RP-HPLC method. ...It also introduce …
Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases.
Wang Q, Song LJ, Ding ZB, Chai Z, Yu JZ, Xiao BG, Ma CG. Wang Q, et al. Neural Regen Res. 2022 Dec;17(12):2623-2631. doi: 10.4103/1673-5374.335827. Neural Regen Res. 2022. PMID: 35662192 Free PMC article. Review.
Fasudil increases the activity of neural stem cells and mesenchymal stem cells, thus optimizing cell therapy. ...This review also proposes that fasudil is a novel potential treatment, especially in combination with cell-based therapy. ...
Fasudil increases the activity of neural stem cells and mesenchymal stem cells, thus optimizing cell therapy. ...This review also pro …
Fasudil alleviates acetaminophen-induced liver injury via targeting Rhoa/ROCK signal pathway.
Ren X, Meng T, Ren X, Li X, Lu L. Ren X, et al. J Toxicol Sci. 2021;46(6):255-262. doi: 10.2131/jts.46.255. J Toxicol Sci. 2021. PMID: 34078832 Free article.
Rhoa/ROCK expression was increased in APAP-induced liver injury, and Fasudil targeted the expression of Rhoa/ROCK. Fasudil inhibits APAP-induced hepatic pathological changes and liver function injury. ...Fasudil alleviates APAP-induced liver injury via target …
Rhoa/ROCK expression was increased in APAP-induced liver injury, and Fasudil targeted the expression of Rhoa/ROCK. Fasudil inh …
Fasudil Increased the Sensitivity to Gefitinib in NSCLC by Decreasing Intracellular Lipid Accumulation.
Liao T, Deng J, Chen W, Xu J, Yang G, Zhou M, Lv Z, Wang S, Song S, Tan X, Yin Z, Li Y, Jin Y. Liao T, et al. Cancers (Basel). 2022 Sep 27;14(19):4709. doi: 10.3390/cancers14194709. Cancers (Basel). 2022. PMID: 36230634 Free PMC article.
Mechanistic investigations showed that Fasudil regulated lipogenic gene expressions via AMPK signal pathway. In vivo, Fasudil and gefitinib co-administration significantly attenuated the growth of H1975 nude mouse xenograft models, suggesting that Fasudil tre …
Mechanistic investigations showed that Fasudil regulated lipogenic gene expressions via AMPK signal pathway. In vivo, Fasudil …
Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders?
Chen M, Liu A, Ouyang Y, Huang Y, Chao X, Pi R. Chen M, et al. Expert Opin Investig Drugs. 2013 Apr;22(4):537-50. doi: 10.1517/13543784.2013.778242. Epub 2013 Mar 5. Expert Opin Investig Drugs. 2013. PMID: 23461757 Review.
Increasing evidences indicate that fasudil could exhibit markedly therapeutic effect on central nervous system (CNS) disorders, such as Alzheimer's disease. AREAS COVERED: This article summarizes results from supporting evidence for the potential therapy for fasudil …
Increasing evidences indicate that fasudil could exhibit markedly therapeutic effect on central nervous system (CNS) disorders, such …
Fasudil Ameliorates Osteoporosis Following Myocardial Infarction by Regulating Cardiac Calcitonin Secretion.
Xiang C, Zhu Y, Xu M, Zhang D. Xiang C, et al. J Cardiovasc Transl Res. 2022 Dec;15(6):1352-1365. doi: 10.1007/s12265-022-10271-8. Epub 2022 May 12. J Cardiovasc Transl Res. 2022. PMID: 35551627
Moreover, fasudil ameliorates the cardiac calcitonin secretion induced by MI in vivo or by H/SD in vitro. Our findings suggest that fasudil improved MI-induced osteoporosis by promoting cardiac secreting calcitonin....
Moreover, fasudil ameliorates the cardiac calcitonin secretion induced by MI in vivo or by H/SD in vitro. Our findings suggest that …
1,518 results