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Quoted phrase not found in phrase index: "Fetal hemoglobin quantitative trait locus 6"
Page 1
Abundant pleiotropy in human complex diseases and traits.
Sivakumaran S, Agakov F, Theodoratou E, Prendergast JG, Zgaga L, Manolio T, Rudan I, McKeigue P, Wilson JF, Campbell H. Sivakumaran S, et al. Am J Hum Genet. 2011 Nov 11;89(5):607-18. doi: 10.1016/j.ajhg.2011.10.004. Am J Hum Genet. 2011. PMID: 22077970 Free PMC article. Review.
SNP pleiotropic status was associated with gene location (p = 0.024; pleiotropic SNPs more often exonic [14.5% versus 4.9% for nonpleiotropic, trait-associated SNPs] and less often intergenic [15.8% versus 23.6%]), "predicted transcript consequence" (p = 0.001; plei …
SNP pleiotropic status was associated with gene location (p = 0.024; pleiotropic SNPs more often exonic [14.5% versus 4.9% for nonpleiotropi …
The association of HBG2, BCL11A, and HMIP polymorphisms with fetal hemoglobin and clinical phenotype in Iraqi Kurds with sickle cell disease.
Al-Allawi N, Qadir SMA, Puehringer H, Chui DHK, Farrell JJ, Oberkanins C. Al-Allawi N, et al. Int J Lab Hematol. 2019 Feb;41(1):87-93. doi: 10.1111/ijlh.12927. Epub 2018 Sep 14. Int J Lab Hematol. 2019. PMID: 30216683
INTRODUCTION: Fetal hemoglobin (HbF) is the major modifier for sickle cell disease (SCD) severity. HbF is modulated mainly by three major quantitative trait loci (QTL) on chromosomes 2, 6, and 11. METHODS: Five SNPs in the three QTLs (HBG2, rs74 …
INTRODUCTION: Fetal hemoglobin (HbF) is the major modifier for sickle cell disease (SCD) severity. HbF is modulated mainly by …
The association between four SNPs (rs7482144, rs4671393, rs28384513 and rs4895441) and fetal hemoglobin levels in Chinese Zhuang beta-thalassemia intermedia patients.
Lai Y, Zhou L, Yi S, Chen Y, Tang Y, Yi S, Yang Z, Wei H, Zheng C, He S. Lai Y, et al. Blood Cells Mol Dis. 2017 Mar;63:52-57. doi: 10.1016/j.bcmd.2017.01.011. Epub 2017 Jan 25. Blood Cells Mol Dis. 2017. PMID: 28160732
Results demonstrated that there was a significantly higher minor allele frequency (MAF=34.2%) of rs4895441 (G) in HMIP in high HbF level group than that in low group (MAF=19.8%) (P=0.001, OR=1.73, 95% CI: 1.24-2.57). The cumulative effects of risk genotypes of these loci f …
Results demonstrated that there was a significantly higher minor allele frequency (MAF=34.2%) of rs4895441 (G) in HMIP in high HbF level gro …
Genetics of fetal hemoglobin in tribal Indian patients with sickle cell anemia.
Bhanushali AA, Patra PK, Pradhan S, Khanka SS, Singh S, Das BR. Bhanushali AA, et al. Transl Res. 2015 Jun;165(6):696-703. doi: 10.1016/j.trsl.2015.01.002. Epub 2015 Jan 13. Transl Res. 2015. PMID: 25651163
In the present study, the first from India, we have investigated the effect of genetic variants in the BCL11A, the HMIP (HBS1L-MYB intergenic polymorphism) locus, in addition to the HBB locus, which are known to be associated with fetal hemoglobin (HbF …
In the present study, the first from India, we have investigated the effect of genetic variants in the BCL11A, the HMIP (HBS1L-MYB intergeni …
A Multi-locus Approach to Characterization of Major Quantitative Trait Loci Influencing Hb F Regulation in Chinese beta-thalassemia Carriers.
Chan NC, Lau KM, Cheng KC, Chan NP, Ng MH. Chan NC, et al. Hemoglobin. 2016 Nov;40(6):400-404. doi: 10.1080/03630269.2016.1245198. Epub 2016 Nov 14. Hemoglobin. 2016. PMID: 27707011
Genetic association studies showed that Hb F is under the influence of major quantitative trait loci (QTL) in beta-thalassemia (beta-thal) carriers. ...The HBS1L-MYB intergenic region polymorphism (HMIP) demonstrated the highest effect on Hb F prediction …
Genetic association studies showed that Hb F is under the influence of major quantitative trait loci (QTL) in beta-thal …