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Quoted phrase not found in phrase index: "Fetal hemoglobin quantitative trait locus 6"
Page 1
Abundant pleiotropy in human complex diseases and traits.
Sivakumaran S, Agakov F, Theodoratou E, Prendergast JG, Zgaga L, Manolio T, Rudan I, McKeigue P, Wilson JF, Campbell H. Sivakumaran S, et al. Am J Hum Genet. 2011 Nov 11;89(5):607-18. doi: 10.1016/j.ajhg.2011.10.004. Am J Hum Genet. 2011. PMID: 22077970 Free PMC article. Review.
We find abundant evidence of pleiotropy; 233 (16.9%) genes and 77 (4.6%) SNPs show pleiotropic effects. SNP pleiotropic status was associated with gene location (p = 0.024; pleiotropic SNPs more often exonic [14.5% versus 4.9% for nonpleiotropic, trait-associated SN …
We find abundant evidence of pleiotropy; 233 (16.9%) genes and 77 (4.6%) SNPs show pleiotropic effects. SNP pleiotropic status was as …
The association of HBG2, BCL11A, and HMIP polymorphisms with fetal hemoglobin and clinical phenotype in Iraqi Kurds with sickle cell disease.
Al-Allawi N, Qadir SMA, Puehringer H, Chui DHK, Farrell JJ, Oberkanins C. Al-Allawi N, et al. Int J Lab Hematol. 2019 Feb;41(1):87-93. doi: 10.1111/ijlh.12927. Epub 2018 Sep 14. Int J Lab Hematol. 2019. PMID: 30216683
INTRODUCTION: Fetal hemoglobin (HbF) is the major modifier for sickle cell disease (SCD) severity. HbF is modulated mainly by three major quantitative trait loci (QTL) on chromosomes 2, 6, and 11. METHODS: Five SNPs in the three QTLs (HBG …
INTRODUCTION: Fetal hemoglobin (HbF) is the major modifier for sickle cell disease (SCD) severity. HbF is modulated mainly by …
Haplotype mapping of a major quantitative-trait locus for fetal hemoglobin production, on chromosome 6q23.
Garner C, Mitchell J, Hatzis T, Reittie J, Farrall M, Thein SL. Garner C, et al. Am J Hum Genet. 1998 Jun;62(6):1468-74. doi: 10.1086/301859. Am J Hum Genet. 1998. PMID: 9585587 Free PMC article.
Fetal hemoglobin (Hb F) and fetal cell (FC) levels in adults show considerable variation and are influenced by several genetic variants; the major determinants appear to be unlinked to the beta-globin gene cluster. ...We have extended the kindred by 57 member …
Fetal hemoglobin (Hb F) and fetal cell (FC) levels in adults show considerable variation and are influenced by several …
Multi-Locus Models to Address Hb F Variability in Portuguese beta-Thalassemia Carriers.
Manco L, Bento C, Relvas L, Cunha E, Pereira J, Moreira V, Alvarez M, Maia T, Ribeiro ML. Manco L, et al. Hemoglobin. 2020 Mar;44(2):113-117. doi: 10.1080/03630269.2020.1753766. Epub 2020 Apr 22. Hemoglobin. 2020. PMID: 32319326
Hb F production is under the influence of major quantitative trait loci (QTL). The present study aims: i) to replicate the association with Hb F for representative genetic variants in the three major Hb F QTLs in a Portuguese sample of beta-thalassemia (beta- …
Hb F production is under the influence of major quantitative trait loci (QTL). The present study aims: i) to replicate …
The association between four SNPs (rs7482144, rs4671393, rs28384513 and rs4895441) and fetal hemoglobin levels in Chinese Zhuang beta-thalassemia intermedia patients.
Lai Y, Zhou L, Yi S, Chen Y, Tang Y, Yi S, Yang Z, Wei H, Zheng C, He S. Lai Y, et al. Blood Cells Mol Dis. 2017 Mar;63:52-57. doi: 10.1016/j.bcmd.2017.01.011. Epub 2017 Jan 25. Blood Cells Mol Dis. 2017. PMID: 28160732
The cumulative effects of risk genotypes of these loci for patients carrying any combination of 1, 2 or 3 risk genotype had a gradually increased risk of high HbF level phenotype compared to those without the risk genotypes (OR=1.50-9.06, P=0.0008); Gene-gene interaction o …
The cumulative effects of risk genotypes of these loci for patients carrying any combination of 1, 2 or 3 risk genotype had a gradual …
A Multi-locus Approach to Characterization of Major Quantitative Trait Loci Influencing Hb F Regulation in Chinese beta-thalassemia Carriers.
Chan NC, Lau KM, Cheng KC, Chan NP, Ng MH. Chan NC, et al. Hemoglobin. 2016 Nov;40(6):400-404. doi: 10.1080/03630269.2016.1245198. Epub 2016 Nov 14. Hemoglobin. 2016. PMID: 27707011
Genetic association studies showed that Hb F is under the influence of major quantitative trait loci (QTL) in beta-thalassemia (beta-thal) carriers. ...The HBS1L-MYB intergenic region polymorphism (HMIP) demonstrated the highest effect on Hb F prediction …
Genetic association studies showed that Hb F is under the influence of major quantitative trait loci (QTL) in beta-thal …
Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.
Mtatiro SN, Singh T, Rooks H, Mgaya J, Mariki H, Soka D, Mmbando B, Msaki E, Kolder I, Thein SL, Menzel S, Cox SE, Makani J, Barrett JC. Mtatiro SN, et al. PLoS One. 2014 Nov 5;9(11):e111464. doi: 10.1371/journal.pone.0111464. eCollection 2014. PLoS One. 2014. PMID: 25372704 Free PMC article.
BACKGROUND: Fetal hemoglobin (HbF) is an important modulator of sickle cell disease (SCD). HbF has previously been shown to be affected by variants at three loci on chromosomes 2, 6 and 11, but it is likely that additional loci remain to be disc …
BACKGROUND: Fetal hemoglobin (HbF) is an important modulator of sickle cell disease (SCD). HbF has previously been shown to be …