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Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice.
Rush BM, Bondi CD, Stocker SD, Barry KM, Small SA, Ong J, Jobbagy S, Stolz DB, Bastacky SI, Chartoumpekis DV, Kensler TW, Tan RJ. Rush BM, et al. Kidney Int. 2021 Jan;99(1):102-116. doi: 10.1016/j.kint.2020.07.036. Epub 2020 Aug 18. Kidney Int. 2021. PMID: 32818518 Free PMC article.
Compared to angiotensin II alone, the combination of angiotensin II and CDDO-Im significantly increased proteinuria, a phenomenon not observed in Nrf2 knockout mice. This effect was not accompanied by additional increases in blood pressure. Finally, Nrf2 was found to be up …
Compared to angiotensin II alone, the combination of angiotensin II and CDDO-Im significantly increased proteinuria, a phenomenon not obs
Fibrillary Glomerulonephritis: Clinicopathologic Features and Atypical Cases from a Multi-Institutional Cohort.
Andeen NK, Troxell ML, Riazy M, Avasare RS, Lapasia J, Jefferson JA, Akilesh S, Najafian B, Nicosia RF, Alpers CE, Smith KD. Andeen NK, et al. Clin J Am Soc Nephrol. 2019 Dec 6;14(12):1741-1750. doi: 10.2215/CJN.03870319. Epub 2019 Nov 4. Clin J Am Soc Nephrol. 2019. PMID: 31685544 Free PMC article.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We sought to (1) determine anatomic characteristics that best define fibrillary GN and (2) identify clinical and pathologic features that predict outcomes. RESULTS: We retrospectively reviewed kidney biopsies from patients …
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We sought to (1) determine anatomic characteristics that best define fibrillary GN and (2 …
Clinical Features and Outcomes of a Racially Diverse Population with Fibrillary Glomerulonephritis.
Payan Schober F, Jobson MA, Poulton CJ, Singh HK, Nickeleit V, Falk RJ, Jennette JC, Nachman PH, Pendergraft Iii WF. Payan Schober F, et al. Am J Nephrol. 2017;45(3):248-256. doi: 10.1159/000455390. Epub 2017 Feb 4. Am J Nephrol. 2017. PMID: 28161700 Free PMC article.
BACKGROUND: Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by electron microscopy. ...Autoimmune diseases, infections and malignancies were frequently observed, present in over half of all cases. C …
BACKGROUND: Fibrillary glomerulonephritis is characterized by randomly arranged fibrils, approximately 20 nm in diameter by el …
IgG Subclass Staining in Routine Renal Biopsy Material.
Hemminger J, Nadasdy G, Satoskar A, Brodsky SV, Nadasdy T. Hemminger J, et al. Am J Surg Pathol. 2016 May;40(5):617-26. doi: 10.1097/PAS.0000000000000605. Am J Surg Pathol. 2016. PMID: 26848798 Review.
The total number of biopsies stained was 1084, which included 367 cases of membranous glomerulonephritis, 307 cases of lupus nephritis, 74 cases of fibrillary glomerulonephritis, 53 cases of proliferative glomerulonephritis with monoclonal IgG deposits, and 25 cases …
The total number of biopsies stained was 1084, which included 367 cases of membranous glomerulonephritis, 307 cases of lupus nephritis, 74 c …
Clinicopathological characteristics and outcome of patients with fibrillary glomerulonephritis: DNAJB9 is a valuable histologic marker.
Liang S, Chen D, Liang D, Xu F, Zhang M, Yang F, Zhu X, Li P, Zeng C. Liang S, et al. J Nephrol. 2021 Jun;34(3):883-892. doi: 10.1007/s40620-020-00783-4. Epub 2020 Jun 18. J Nephrol. 2021. PMID: 32557205
BACKGROUND: Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. DNAJB9 as a new reliable diagnostic marker for the diagnosis of FGN was discovered recently. ...RESULTS: Strong DNAJB9 staining of glomerular extracellular deposits was observed in …
BACKGROUND: Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. DNAJB9 as a new reliable diagnostic marker for t …
Fibrillary and immunotactoid glomerulonephritis: Distinct entities with different clinical and pathologic features.
Rosenstock JL, Markowitz GS, Valeri AM, Sacchi G, Appel GB, D'Agati VD. Rosenstock JL, et al. Kidney Int. 2003 Apr;63(4):1450-61. doi: 10.1046/j.1523-1755.2003.00853.x. Kidney Int. 2003. PMID: 12631361 Free article.
BACKGROUND: Controversy surrounds the relatedness of fibrillary glomerulonephritis (FGN) and immunotactoid glomerulonephritis (IT). ...By Cox regression (hazard ratio, confidence interval, P value), independent predictors of progression to ESRD were creatinin …
BACKGROUND: Controversy surrounds the relatedness of fibrillary glomerulonephritis (FGN) and immunotactoid glomerulonephritis …
Recurrence of DNAJB9-Positive Fibrillary Glomerulonephritis After Kidney Transplantation: A Case Series.
El Ters M, Bobart SA, Cornell LD, Leung N, Bentall A, Sethi S, Fidler M, Grande J, Hernandez LH, Cosio FG, Zand L, Amer H, Fervenza FC, Nasr SH, Alexander MP. El Ters M, et al. Am J Kidney Dis. 2020 Oct;76(4):500-510. doi: 10.1053/j.ajkd.2020.01.018. Epub 2020 May 12. Am J Kidney Dis. 2020. PMID: 32414663
RATIONALE & OBJECTIVE: Fibrillary glomerulonephritis (FGN) is a rare glomerular disease that often progresses to kidney failure requiring kidney replacement therapy. ...Summary statistical analysis was performed, including nonparametric statistical tests. OBS
RATIONALE & OBJECTIVE: Fibrillary glomerulonephritis (FGN) is a rare glomerular disease that often progresses to kidney fa …
Serum levels of DNAJB9 are elevated in fibrillary glomerulonephritis patients.
Nasr SH, Dasari S, Lieske JC, Benson LM, Vanderboom PM, Holtz-Heppelmann CJ, Giesen CD, Snyder MR, Erickson SB, Fervenza FC, Leung N, Kurtin PJ, Alexander MP. Nasr SH, et al. Kidney Int. 2019 May;95(5):1269-1272. doi: 10.1016/j.kint.2019.01.024. Epub 2019 Mar 1. Kidney Int. 2019. PMID: 31010480 Free article.
Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. Kidney biopsy is required to establish the diagnosis. ...Serum DNAJB9 levels were also negatively associated with estimated glomerular filtration rate in patients with FGN. Serum DNAJB9 levels accurat
Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. Kidney biopsy is required to establish the diagnosis. ...Ser
Fibrillary glomerulonephritis: a diagnosis not to be missed'.
Kfoury HK. Kfoury HK. Saudi J Kidney Dis Transpl. 2012 Nov;23(6):1246-50. doi: 10.4103/1319-2442.103569. Saudi J Kidney Dis Transpl. 2012. PMID: 23168858
Fibrillary glomerulonephritis (Fib GN) is among the newly recognized primary glomerular diseases. ...
Fibrillary glomerulonephritis (Fib GN) is among the newly recognized primary glomerular diseases. ...
Fibrillary glomerulonephritis in siblings.
Chan TM, Chan KW. Chan TM, et al. Am J Kidney Dis. 1998 May;31(5):E4. doi: 10.1016/s0272-6386(98)70066-6. Am J Kidney Dis. 1998. PMID: 10074581
Despite the generally poor renal prognosis reported in the literature, with 50% of patients reaching end-stage renal failure within 2 to 4 years, both patients had relative preservation of renal function (creatinine clearance from 79 to 76 mL/min/1.73 m2 after 2 years in one pati …
Despite the generally poor renal prognosis reported in the literature, with 50% of patients reaching end-stage renal failure within 2 to 4 y …
22 results