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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1995 1
2002 1
2003 1
2005 1
2006 1
2007 3
2009 2
2013 1
2015 2
2016 2
2017 2
2019 2
2020 3
2021 2
2022 3
2023 2
2024 0

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15 results

Results by year

Filters applied: Meta-Analysis, Review, Systematic Review, in the last 10 years. Clear all
Page 1
Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease.
Phillips IR, Shephard EA. Phillips IR, et al. Xenobiotica. 2020 Jan;50(1):19-33. doi: 10.1080/00498254.2019.1643515. Epub 2019 Aug 1. Xenobiotica. 2020. PMID: 31317802 Review.
The review focuses on genetic variants of human flavin-containing monooxygenase 3 (FMO3) and their impact on enzyme activity, drug metabolism and disease.The majority of FMO-mediated metabolism in adult human liver is catalyzed by FMO3. ...
The review focuses on genetic variants of human flavin-containing monooxygenase 3 (FMO3) and their impact on enz …
The roles of microbial products in the development of colorectal cancer: a review.
Fang Y, Yan C, Zhao Q, Xu J, Liu Z, Gao J, Zhu H, Dai Z, Wang D, Tang D. Fang Y, et al. Bioengineered. 2021 Dec;12(1):720-735. doi: 10.1080/21655979.2021.1889109. Bioengineered. 2021. PMID: 33618627 Free PMC article. Review.
In this review, recent studies are examined in order to describe the contribution metabolites and toxicants which are produced by gut microbes make to CRC, primarily focusing on the involved molecular mechanisms.Abbreviations: CRC: colorectal cancer; SCFAs: short chain fatty acid …
In this review, recent studies are examined in order to describe the contribution metabolites and toxicants which are produced by gut microb …
Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease.
Fennema D, Phillips IR, Shephard EA. Fennema D, et al. Drug Metab Dispos. 2016 Nov;44(11):1839-1850. doi: 10.1124/dmd.116.070615. Epub 2016 May 17. Drug Metab Dispos. 2016. PMID: 27190056 Free PMC article. Review.
Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in the metabolism of therapeutic drugs. ...
Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in the metabolism of therapeut …
Primary Trimethylaminuria.
Phillips IR, Shephard EA. Phillips IR, et al. 2007 Oct 8 [updated 2020 Nov 5]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2007 Oct 8 [updated 2020 Nov 5]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301282 Free Books & Documents. Review.
The roles of trimethylamine-N-oxide in atherosclerosis and its potential therapeutic aspect: A literature review.
Oktaviono YH, Dyah Lamara A, Saputra PBT, Arnindita JN, Pasahari D, Saputra ME, Suasti NMA. Oktaviono YH, et al. Biomol Biomed. 2023 Nov 3;23(6):936-948. doi: 10.17305/bb.2023.8893. Biomol Biomed. 2023. PMID: 37337893 Free PMC article. Review.
Conversely, indole-3-carbinol (I3C) and trigonelline inhibit TMA oxidation by inhibiting flavin-containing monooxygenase-3 (FMO3), resulting in reduced plasma TMAO. The combined use of inhibitors of choline trimethylamine lyase and flavin-con …
Conversely, indole-3-carbinol (I3C) and trigonelline inhibit TMA oxidation by inhibiting flavin-containing monooxygenase …
Treatments of trimethylaminuria: where we are and where we might be heading.
Schmidt AC, Leroux JC. Schmidt AC, et al. Drug Discov Today. 2020 Sep;25(9):1710-1717. doi: 10.1016/j.drudis.2020.06.026. Epub 2020 Jun 29. Drug Discov Today. 2020. PMID: 32615074 Free article. Review.
In primary trimethylaminuria (TMAU), an inherited deficiency in flavin-containing monooxygenase 3 leads to elevated systemic TMA levels. ...
In primary trimethylaminuria (TMAU), an inherited deficiency in flavin-containing monooxygenase 3 leads to eleva …
Trimethylamine-N-Oxide: Friend, Foe, or Simply Caught in the Cross-Fire?
Cho CE, Caudill MA. Cho CE, et al. Trends Endocrinol Metab. 2017 Feb;28(2):121-130. doi: 10.1016/j.tem.2016.10.005. Epub 2016 Nov 5. Trends Endocrinol Metab. 2017. PMID: 27825547 Review.
However, the relation between TMAO and chronic disease can be confounded by several factors, including kidney function, the gut microbiome, and flavin-containing monooxygenase 3 (FMO3) genotype. Thus, whether TMAO is a causative agent in human disease …
However, the relation between TMAO and chronic disease can be confounded by several factors, including kidney function, the gut microbiome, …
Transport and metabolism of tyrosine kinase inhibitors associated with chronic myeloid leukemia therapy: a review.
Kumar V, Singh P, Gupta SK, Ali V, Verma M. Kumar V, et al. Mol Cell Biochem. 2022 Apr;477(4):1261-1279. doi: 10.1007/s11010-022-04376-6. Epub 2022 Feb 7. Mol Cell Biochem. 2022. PMID: 35129779 Review.
A phenomenon common to all in the metabolic aspect is that the CYP3A4 isoform of CYP450 primarily metabolizes TKIs. Not only does CYP3A4, flavin-containing monooxygenase 3 (FMO3), and uridine 5'-diphospho-glucuronosyltransferase (UGT) also metabolize d …
A phenomenon common to all in the metabolic aspect is that the CYP3A4 isoform of CYP450 primarily metabolizes TKIs. Not only does CYP3A4, …
15 results