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Quoted phrase not found in phrase index: "Frontotemporal dementia and/or amyotrophic lateral sclerosis 2"
Page 1
Frontotemporal dementia: diagnosis, deficits and management.
Bott NT, Radke A, Stephens ML, Kramer JH. Bott NT, et al. Neurodegener Dis Manag. 2014;4(6):439-54. doi: 10.2217/nmt.14.34. Neurodegener Dis Manag. 2014. PMID: 25531687 Free PMC article. Review.
Frontotemporal dementia (FTD) is a progressive neurologic syndrome with diverse clinical presentations and attendant underlying pathologies. ...In what follows, we review each of the FTD syndromes, highlight current research investigating the cognitive, behavioral a …
Frontotemporal dementia (FTD) is a progressive neurologic syndrome with diverse clinical presentations and attendant underlyin …
Behavioral Variant Frontotemporal Dementia.
Boeve BF. Boeve BF. Continuum (Minneap Minn). 2022 Jun 1;28(3):702-725. doi: 10.1212/CON.0000000000001105. Continuum (Minneap Minn). 2022. PMID: 35678399 Free PMC article. Review.
PURPOSE OF REVIEW: This article reviews many of the complex facets of behavioral variant frontotemporal dementia (bvFTD) and frontotemporal lobar degeneration (FTLD). ...This article presents updated data along with illustrative cases to emphasize the clinica …
PURPOSE OF REVIEW: This article reviews many of the complex facets of behavioral variant frontotemporal dementia (bvFTD) and …
Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model.
Westeneng HJ, Debray TPA, Visser AE, van Eijk RPA, Rooney JPK, Calvo A, Martin S, McDermott CJ, Thompson AG, Pinto S, Kobeleva X, Rosenbohm A, Stubendorff B, Sommer H, Middelkoop BM, Dekker AM, van Vugt JJFA, van Rheenen W, Vajda A, Heverin M, Kazoka M, Hollinger H, Gromicho M, Körner S, Ringer TM, Rödiger A, Gunkel A, Shaw CE, Bredenoord AL, van Es MA, Corcia P, Couratier P, Weber M, Grosskreutz J, Ludolph AC, Petri S, de Carvalho M, Van Damme P, Talbot K, Turner MR, Shaw PJ, Al-Chalabi A, Chiò A, Hardiman O, Moons KGM, Veldink JH, van den Berg LH. Westeneng HJ, et al. Lancet Neurol. 2018 May;17(5):423-433. doi: 10.1016/S1474-4422(18)30089-9. Epub 2018 Mar 26. Lancet Neurol. 2018. PMID: 29598923 Free article.
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive, fatal motor neuron disease with a variable natural history. ...The median follow-up time was 97.5 months (IQR 52.9-168.5). Eight candidate predictors entered the predicti …
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive, fatal motor neuron disease with a variab …
RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia.
McMillan M, Gomez N, Hsieh C, Bekier M, Li X, Miguez R, Tank EMH, Barmada SJ. McMillan M, et al. Mol Cell. 2023 Jan 19;83(2):219-236.e7. doi: 10.1016/j.molcel.2022.12.019. Epub 2023 Jan 11. Mol Cell. 2023. PMID: 36634675 Free PMC article.
RNA methylation at adenosine N6 (m6A) is one of the most common RNA modifications, impacting RNA stability, transport, and translation. Previous studies uncovered RNA destabilization in amyotrophic lateral sclerosis (ALS) models in association with accumulati …
RNA methylation at adenosine N6 (m6A) is one of the most common RNA modifications, impacting RNA stability, transport, and translation. Prev …
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ. Mann JR, et al. Neuron. 2019 Apr 17;102(2):321-338.e8. doi: 10.1016/j.neuron.2019.01.048. Epub 2019 Feb 27. Neuron. 2019. PMID: 30826182 Free PMC article.
TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within degenerating regions of patient postmortem tissue. ...
TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia …
Frontotemporal Dementias.
Finger EC. Finger EC. Continuum (Minneap Minn). 2016 Apr;22(2 Dementia):464-89. doi: 10.1212/CON.0000000000000300. Continuum (Minneap Minn). 2016. PMID: 27042904 Free PMC article. Review.
PURPOSE OF REVIEW: This article reviews the common behavioral and cognitive features of frontotemporal dementia (FTD) and related disorders as well as the distinguishing clinical, genetic, and pathologic features of the most common subtypes. RECENT FINDINGS: Advance …
PURPOSE OF REVIEW: This article reviews the common behavioral and cognitive features of frontotemporal dementia (FTD) and rela …
Frontotemporal dementia: Past, present, and future.
Ulugut H, Pijnenburg YAL. Ulugut H, et al. Alzheimers Dement. 2023 Nov;19(11):5253-5263. doi: 10.1002/alz.13363. Epub 2023 Jun 28. Alzheimers Dement. 2023. PMID: 37379561 Review.
INTRODUCTION: The history of frontotemporal dementia (FTD) is both old and new. This study explores its historical roots, dating back to the 19th century, while recognizes it as a distinct neurological entity only a few decades ago. ...RESULTS: Recognition of FTD wa …
INTRODUCTION: The history of frontotemporal dementia (FTD) is both old and new. This study explores its historical roots, dati …
TDP-43 forms amyloid filaments with a distinct fold in type A FTLD-TDP.
Arseni D, Chen R, Murzin AG, Peak-Chew SY, Garringer HJ, Newell KL, Kametani F, Robinson AC, Vidal R, Ghetti B, Hasegawa M, Ryskeldi-Falcon B. Arseni D, et al. Nature. 2023 Aug;620(7975):898-903. doi: 10.1038/s41586-023-06405-w. Epub 2023 Aug 2. Nature. 2023. PMID: 37532939 Free PMC article.
The abnormal assembly of TAR DNA-binding protein 43 (TDP-43) in neuronal and glial cells characterizes nearly all cases of amyotrophic lateral sclerosis (ALS) and around half of cases of frontotemporal lobar degeneration (FTLD)(1,2). ...At least …
The abnormal assembly of TAR DNA-binding protein 43 (TDP-43) in neuronal and glial cells characterizes nearly all cases of amyotrophic …
Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS.
Parameswaran J, Zhang N, Braems E, Tilahun K, Pant DC, Yin K, Asress S, Heeren K, Banerjee A, Davis E, Schwartz SL, Conn GL, Bassell GJ, Van Den Bosch L, Jiang J. Parameswaran J, et al. Elife. 2023 Apr 19;12:e85902. doi: 10.7554/eLife.85902. Elife. 2023. PMID: 37073950 Free PMC article.
GGGGCC (G(4)C(2)) hexanucleotide repeat expansion in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). ...Finally, only antisense C(4)G(2), but not sense G(4 …
GGGGCC (G(4)C(2)) hexanucleotide repeat expansion in the C9ORF72 gene is the most common genetic cause of frontotemporal de …
Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies.
Young AL, Vogel JW, Robinson JL, McMillan CT, Ossenkoppele R, Wolk DA, Irwin DJ, Elman L, Grossman M, Lee VMY, Lee EB, Hansson O. Young AL, et al. Brain. 2023 Jul 3;146(7):2975-2988. doi: 10.1093/brain/awad145. Brain. 2023. PMID: 37150879 Free PMC article.
Here, we use data-driven disease progression modelling to derive a fine-grained empirical staging system for the classification and differentiation of frontotemporal lobar degeneration due to TDP-43 (FTLD-TDP, n = 126), amyotrophic lateral sclerosis (A …
Here, we use data-driven disease progression modelling to derive a fine-grained empirical staging system for the classification and differen …
5,352 results