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33 results

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Page 1
Multi-Trait Genetic Analysis Reveals Clinically Interpretable Hypertension Subtypes.
Vaura F, Kim H, Udler MS; FinnGen*; Salomaa V, Lahti L, Niiranen T. Vaura F, et al. Circ Genom Precis Med. 2022 Aug;15(4):e003583. doi: 10.1161/CIRCGEN.121.003583. Epub 2022 May 23. Circ Genom Precis Med. 2022. PMID: 35604428 Free PMC article.
METHODS: Our study sample comprised N=198 148 FinnGen participants (56% women, mean age 58 years) and N=21 168 well-phenotyped FINRISK participants (53% women, mean age 50 years). First, we identified genetic hypertension components with an unsupervised Bayesian non …
METHODS: Our study sample comprised N=198 148 FinnGen participants (56% women, mean age 58 years) and N=21 168 well-phenotyped FINRISK parti …
Counterregulatory actions of angiotensin-(1-7).
Ferrario CM, Chappell MC, Tallant EA, Brosnihan KB, Diz DI. Ferrario CM, et al. Hypertension. 1997 Sep;30(3 Pt 2):535-41. doi: 10.1161/01.hyp.30.3.535. Hypertension. 1997. PMID: 9322978 Review.
Thus, the accumulating evidence suggests that Ang-(1-7) may oppose the actions of Ang II either directly or by stimulation of prostaglandins and nitric oxide. These observations are significant because they may explain the effective antihypertensive action of converting en …
Thus, the accumulating evidence suggests that Ang-(1-7) may oppose the actions of Ang II either directly or by stimulation of prostaglandins …
Genetic hypertension and increased susceptibility to cerebral ischemia.
Barone FC, Price WJ, White RF, Willette RN, Feuerstein GZ. Barone FC, et al. Neurosci Biobehav Rev. 1992 Summer;16(2):219-33. doi: 10.1016/s0149-7634(05)80182-4. Neurosci Biobehav Rev. 1992. PMID: 1630732 Review.
Also, a significant degree of ipsilateral hemispheric swelling (4.6 +/- 0.9%, N = 7-9, p less than 0.05) and increased brain water content (78.4 +/- 0.3% to 80.4 +/- 0.2%, N = 8-9, p less than 0.05) was identified in SHR that was not observed in SD or WKY rats. A novel mod …
Also, a significant degree of ipsilateral hemispheric swelling (4.6 +/- 0.9%, N = 7-9, p less than 0.05) and increased brain water content ( …
Molecular biology of Na+ absorption.
Barbry P, Hofman P. Barbry P, et al. Am J Physiol. 1997 Sep;273(3 Pt 1):G571-85. doi: 10.1152/ajpgi.1997.273.3.G571. Am J Physiol. 1997. PMID: 9316461 Review.
Gain-of-function mutations affecting beta-ENaC and gamma-ENaC genes can cause Liddle syndrome, a rare from of genetic hypertension. Loss-of-function mutations affecting alpha-ENaC or beta-ENaC genes can cause pseudohypoaldosteronism type 1. Steroids strongly increas …
Gain-of-function mutations affecting beta-ENaC and gamma-ENaC genes can cause Liddle syndrome, a rare from of genetic hypertension …
Membrane handling of calcium in essential hypertension.
Bing RF, Heagerty AM, Swales JD. Bing RF, et al. J Hypertens Suppl. 1987 Dec;5(4):S29-35. doi: 10.1097/00004872-198712004-00006. J Hypertens Suppl. 1987. PMID: 2831320 Review.
Several abnormalities have been described in the blood-cell handling of calcium in patients with hypertension and rats with genetic hypertension. We have suggested elsewhere that the multiple abnormalities of monovalent and divalent ion handling by blood cells in hy …
Several abnormalities have been described in the blood-cell handling of calcium in patients with hypertension and rats with genetic …
Salivary kallikrein excretion in hypertension.
Heidland A, Röckel A, Schmid G. Heidland A, et al. Klin Wochenschr. 1979 Oct 1;57(19):1047-52. doi: 10.1007/BF01479990. Klin Wochenschr. 1979. PMID: 392178 Review.
An increased salivary kallikrein concentration is found in human essential hypertension and renoparenchymal hypertension associated with impaired kidney function. Furthermore in rats with various forms of hypertension (genetic hypertension, DOCTMA salt and renovascu …
An increased salivary kallikrein concentration is found in human essential hypertension and renoparenchymal hypertension associated with imp …
Hippocampus under Pressure: Molecular Mechanisms of Development of Cognitive Impairments in SHR Rats.
Stepanichev MY, Mamedova DI, Gulyaeva NV. Stepanichev MY, et al. Biochemistry (Mosc). 2024 Apr;89(4):711-725. doi: 10.1134/S0006297924040102. Biochemistry (Mosc). 2024. PMID: 38831507 Review.
Here, we review structural and biochemical alterations in the hippocampus of SHR rats with genetic hypertension, which are used as a model of essential hypertension and vascular dementia. In addition to hypertension, dysfunction of the hypothalamic-pituitary-adrenal …
Here, we review structural and biochemical alterations in the hippocampus of SHR rats with genetic hypertension, which are use …
Interplay of the Mediterranean diet and genetic hypertension risk on blood pressure in European adolescents: Findings from the HELENA study.
Pérez-Gimeno G, Seral-Cortes M, Sabroso-Lasa S, Esteban LM, Widhalm K, Gottrand F, Stehle P, Meirhaeghe A, Muntaner M, Kafatos A, Gutierrez A, Manios Y, Anastasiou CA, Gonzalez-Gross M, Breidenassel C, Censi L, de Henauw S, Labayen I, Bueno-Lozano G, Rupérez AI, Moreno LA. Pérez-Gimeno G, et al. Eur J Pediatr. 2024 May;183(5):2101-2110. doi: 10.1007/s00431-024-05435-4. Epub 2024 Feb 13. Eur J Pediatr. 2024. PMID: 38349423 Free PMC article.
Multiple linear regression models, adjusted for covariates, were employed to examine the relationship between the MedDiet score and BP z-scores and to assess the interaction effects between the MedDiet score and HTN-GRS on BP z-scores. MedDiet score …
Multiple linear regression models, adjusted for covariates, were employed to examine the relationship between the MedDiet score and B …
Contribution of Rare and Common Genetic Variants to Plasma Lipid Levels and Carotid Stiffness and Geometry: A Substudy of the Paris Prospective Study 3.
Proust C, Empana JP, Boutouyrie P, Alivon M, Challande P, Danchin N, Escriou G, Esslinger U, Laurent S, Li Z, Pannier B, Regnault V, Thomas F, Jouven X, Cambien F, Lacolley P. Proust C, et al. Circ Cardiovasc Genet. 2015 Aug;8(4):628-36. doi: 10.1161/CIRCGENETICS.114.000979. Epub 2015 Jul 9. Circ Cardiovasc Genet. 2015. PMID: 26160806
Significant V(G)/V(p) ratios were observed for external (14.5%, P<2.710(-5)) and internal diameter (13.4%, P<4.310(-4)), stiffness (12.5%, P<8.010(-4)), intima-media thickness (10.6%, P<7.910(-4)), and wall cross-sectional area (13.2%, P<2.410(-5)). A signif …
Significant V(G)/V(p) ratios were observed for external (14.5%, P<2.710(-5)) and internal diameter (13.4%, P<4.310(-4)), stiffn …
Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome.
Friese RS, Ye C, Nievergelt CM, Schork AJ, Mahapatra NR, Rao F, Napolitan PS, Waalen J, Ehret GB, Munroe PB, Schmid-Schönbein GW, Eskin E, O'Connor DT. Friese RS, et al. Circ Cardiovasc Genet. 2012 Aug 1;5(4):430-40. doi: 10.1161/CIRCGENETICS.111.962415. Epub 2012 Jun 5. Circ Cardiovasc Genet. 2012. PMID: 22670052 Free PMC article.
We finally hypothesized that genetic variation at HOXA3, SRY, and YY1 might predict blood pressure and other metabolic syndrome traits in humans. ...
We finally hypothesized that genetic variation at HOXA3, SRY, and YY1 might predict blood pressure and other metabolic syndrome trait …
33 results