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The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt/beta-catenin signaling pathway.
Liu J, Deng X, Liang X, Li L. Liu J, et al. J Biochem Mol Toxicol. 2021 Feb;35(2):e22653. doi: 10.1002/jbt.22653. Epub 2020 Oct 28. J Biochem Mol Toxicol. 2021. PMID: 33113278
This study systematically investigated the effects of phytoestrogen glabrene on postmenopausal osteoporosis in an ovariectomy (OVX) rat model. ...Moreover, glabrene greatly suppressed the expression of TRAP protein but increased OPG and BGP protein expression in tib …
This study systematically investigated the effects of phytoestrogen glabrene on postmenopausal osteoporosis in an ovariectomy (OVX) r …
Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots.
Nerya O, Vaya J, Musa R, Izrael S, Ben-Arie R, Tamir S. Nerya O, et al. J Agric Food Chem. 2003 Feb 26;51(5):1201-7. doi: 10.1021/jf020935u. J Agric Food Chem. 2003. PMID: 12590456
The IC(50) values for glabrene and isoliquiritigenin were 3.5 and 8.1 microM, respectively, when tyrosine was used as substrate. The effects of glabrene and isoliquiritigenin on tyrosinase activity were dose-dependent and correlated to their ability to inhibit melan …
The IC(50) values for glabrene and isoliquiritigenin were 3.5 and 8.1 microM, respectively, when tyrosine was used as substrate. The …
Regulatory mechanism of the Glabrene against non-small cell lung cancer by suppressing FGFR3.
He M, Wu H, Hu L, Liu N, Zhang G, Wang S. He M, et al. Environ Toxicol. 2024 Mar 22. doi: 10.1002/tox.24235. Online ahead of print. Environ Toxicol. 2024. PMID: 38517198
This study aimed to investigate the regulatory mechanism of Glabrene on NSCLC through its interaction with FGFR3. METHODS: HCC827 cells were implanted into nude mice and treated with Glabrene. ...Besides, Glabrene could reduce the FGFR3 expression in HCC827 c …
This study aimed to investigate the regulatory mechanism of Glabrene on NSCLC through its interaction with FGFR3. METHODS: HCC827 cel …
Estrogen-like activity of glabrene and other constituents isolated from licorice root.
Tamir S, Eizenberg M, Somjen D, Izrael S, Vaya J. Tamir S, et al. J Steroid Biochem Mol Biol. 2001 Sep;78(3):291-8. doi: 10.1016/s0960-0760(01)00093-0. J Steroid Biochem Mol Biol. 2001. PMID: 11595510
The stimulatory effects of glabrene in vivo were tissue specific and similar to those of estradiol. The effect of increasing concentrations of glabrene and ILC on the growth of breast tumor cell were biphasic. ...
The stimulatory effects of glabrene in vivo were tissue specific and similar to those of estradiol. The effect of increasing concentr …
Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues.
Somjen D, Katzburg S, Vaya J, Kaye AM, Hendel D, Posner GH, Tamir S. Somjen D, et al. J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):241-6. doi: 10.1016/j.jsbmb.2004.04.008. J Steroid Biochem Mol Biol. 2004. PMID: 15336701
In pre-menopausal human bone cells, the response to estradiol-17beta and glabridin (at higher concentration) was higher than in post-menopausal cells; whereas, glabrene (at higher concentration) was more effective in post-menopausal cells. At both ages, the response to est …
In pre-menopausal human bone cells, the response to estradiol-17beta and glabridin (at higher concentration) was higher than in post-menopau …
Prenylated isoflavonoids from Fabaceae against the NorA efflux pump in Staphylococcus aureus.
Ika Irianti M, Vincken JP, van Dinteren S, Ter Beest E, Pos KM, Araya-Cloutier C. Ika Irianti M, et al. Sci Rep. 2023 Dec 18;13(1):22548. doi: 10.1038/s41598-023-48992-8. Sci Rep. 2023. PMID: 38110428 Free PMC article.
We found that four prenylated isoflavonoids, namely neobavaisoflavone, glabrene, glyceollin I, and glyceollin III, showed efflux pump inhibition in the norA overexpressing S. aureus. At sub-inhibitory concentrations, neobavaisoflavone (6.25 g/mL, 19 M) and glabrene …
We found that four prenylated isoflavonoids, namely neobavaisoflavone, glabrene, glyceollin I, and glyceollin III, showed efflux pump …
Bioactive Phytoconstituents as Potent Inhibitors of Tyrosine-Protein Kinase Yes (YES1): Implications in Anticancer Therapeutics.
Yang C, Alam A, Alhumaydhi FA, Khan MS, Alsagaby SA, Al Abdulmonem W, Hassan MI, Shamsi A, Bano B, Yadav DK. Yang C, et al. Molecules. 2022 May 10;27(10):3060. doi: 10.3390/molecules27103060. Molecules. 2022. PMID: 35630545 Free PMC article.
Then binding affinities calculation, PAINS filter, ADMET, and PASS analyses followed by an interaction analysis to select safe and clinically better hits. Finally, two compounds, Glabrene and Lupinisoflavone C (LIC), with appreciable affinities and a specific interaction t …
Then binding affinities calculation, PAINS filter, ADMET, and PASS analyses followed by an interaction analysis to select safe and clinicall …
Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo.
Somjen D, Knoll E, Vaya J, Stern N, Tamir S. Somjen D, et al. J Steroid Biochem Mol Biol. 2004 Jul;91(3):147-55. doi: 10.1016/j.jsbmb.2004.04.003. J Steroid Biochem Mol Biol. 2004. PMID: 15276622
In the present study, we tested the effects on vascular tissues in vitro and in vivo of two natural compounds derived from licorice root: glabridin, the major isoflavan, and glabrene, an isoflavene, both demonstrated estrogen-like activities. ...In animal studies, both int …
In the present study, we tested the effects on vascular tissues in vitro and in vivo of two natural compounds derived from licorice root: gl …
Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra).
Simons R, Vincken JP, Mol LA, The SA, Bovee TF, Luijendijk TJ, Verbruggen MA, Gruppen H. Simons R, et al. Anal Bioanal Chem. 2011 Jul;401(1):305-13. doi: 10.1007/s00216-011-5061-9. Epub 2011 May 15. Anal Bioanal Chem. 2011. PMID: 21573846 Free PMC article.
One third of the fractions displayed estrogenic activity towards either one or both estrogen receptors (ERs; ERalpha and ERbeta). Glabrene-rich fractions displayed an estrogenic response, predominantly to the ERalpha. ...Whereas glabridin was able to reduce the estrogenic …
One third of the fractions displayed estrogenic activity towards either one or both estrogen receptors (ERs; ERalpha and ERbeta). Glabren …
A virtual screening investigation to identify bioactive natural compounds as potential inhibitors of cyclin-dependent kinase 9.
Atiya A, Shahidi H, Mohammad T, Sharaf SE, Abdulmonem WA, Ashraf GM, Elasbali AM, Alharethi SH, Alhumaydhi FA, Baeesa SS, Rehan M, Shamsi A, Shahwan M. Atiya A, et al. J Biomol Struct Dyn. 2023 Nov;41(19):10202-10213. doi: 10.1080/07391102.2022.2153921. Epub 2022 Dec 23. J Biomol Struct Dyn. 2023. PMID: 36562191
This screening resulted in the identification of two natural compounds, Glabrene and Guggulsterone with high affinity and specificity for the CDK9 binding site. ...Further, the dynamics and consistency of CDK9 interaction with Glabrene and Guggulsteron were evaluate …
This screening resulted in the identification of two natural compounds, Glabrene and Guggulsterone with high affinity and specificity …
28 results