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1988 2
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1994 1
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1996 5
1997 3
1998 3
1999 2
2000 5
2001 8
2002 4
2003 5
2004 6
2005 11
2006 17
2007 13
2008 22
2009 19
2010 22
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2012 26
2013 36
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Quoted phrase not found in phrase index: "Glioma susceptibility 1"
Page 1
The genomic landscape of familial glioma.
Choi DJ, Armstrong G, Lozzi B, Vijayaraghavan P, Plon SE, Wong TC, Boerwinkle E, Muzny DM, Chen HC, Gibbs RA, Ostrom QT, Melin B, Deneen B, Bondy ML; Gliogene Consortium; Genomics England Research Consortium; Bainbridge MN, Amos CI, Barnholtz-Sloan JS, Bernstein JL, Claus EB, Houlston RS, Il'yasova D, Jenkins RB, Johansen C, Lachance D, Lai R, Melin BS, Merrell RT, Olson SH, Sadetzki S, Schildkraut J, Shete S, Ambrose JC, Arumugam P, Bevers R, Bleda M, Boardman-Pretty F, Boustred CR, Brittain H, Brown MA, Caulfield MJ, Chan GC, Giess A, Griffin JN, Hamblin A, Henderson S, Hubbard TJP, Jackson R, Jones LJ, Kasperaviciute D, Kayikci M, Kousathanas A, Lahnstein L, Lakey A, Leigh SEA, Leong IUS, Lopez FJ, Maleady-Crowe F, McEntagart M, Minneci F, Mitchell J, Moutsianas L, Mueller M, Murugaesu N, Need AC, O'Donovan P, Odhams CA, Patch C, Perez-Gil D, Pereira MB, Pullinger J, Rahim T, Rendon A, Rogers T, Savage K, Sawant K, Scott RH, Siddiq A, Sieghart A, Smith SC, Sosinsky A, Stuckey A, Tanguy M, Taylor Tavares AL, Thomas ERA, Thompson SR, Tucci A, Welland MJ, Williams E, Witkowska K, Wood SM, Zarowiecki M. Choi DJ, et al. Sci Adv. 2023 Apr 28;9(17):eade2675. doi: 10.1126/sciadv.ade2675. Epub 2023 Apr 28. Sci Adv. 2023. PMID: 37115922 Free PMC article.
Glioma is a rare brain tumor with a poor prognosis. Familial glioma is a subset of glioma with a strong genetic predisposition that accounts for approximately 5% of glioma cases. ...This study performs comprehensive surveillance of the genomic landscap …
Glioma is a rare brain tumor with a poor prognosis. Familial glioma is a subset of glioma with a strong genetic predisp …
Melanoma genetics.
Read J, Wadt KA, Hayward NK. Read J, et al. J Med Genet. 2016 Jan;53(1):1-14. doi: 10.1136/jmedgenet-2015-103150. Epub 2015 Sep 3. J Med Genet. 2016. PMID: 26337759 Review.
Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of heritable melanoma risk genes is an important component of disease occurrence. Susceptibility for some families is due to mutation in one of the …
Although the majority of genetic alterations associated with melanoma development are somatic, the underlying presence of heritable melanoma …
2-Hydroxyglutarate in Cancer Cells.
Ježek P. Ježek P. Antioxid Redox Signal. 2020 Nov 1;33(13):903-926. doi: 10.1089/ars.2019.7902. Epub 2020 Jan 22. Antioxid Redox Signal. 2020. PMID: 31847543 Free PMC article. Review.
However, even wild-type IDH1 and IDH2, notably under shifts toward reductive carboxylation glutaminolysis or changes in other enzymes, lead to "intermediate" 0.01-0.1 mM 2HG levels, for example, in breast carcinoma compared with 10(-8)M in noncancer cells. Future Direction …
However, even wild-type IDH1 and IDH2, notably under shifts toward reductive carboxylation glutaminolysis or changes in other enzymes, lead …
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.
Waszak SM, Northcott PA, Buchhalter I, Robinson GW, Sutter C, Groebner S, Grund KB, Brugières L, Jones DTW, Pajtler KW, Morrissy AS, Kool M, Sturm D, Chavez L, Ernst A, Brabetz S, Hain M, Zichner T, Segura-Wang M, Weischenfeldt J, Rausch T, Mardin BR, Zhou X, Baciu C, Lawerenz C, Chan JA, Varlet P, Guerrini-Rousseau L, Fults DW, Grajkowska W, Hauser P, Jabado N, Ra YS, Zitterbart K, Shringarpure SS, De La Vega FM, Bustamante CD, Ng HK, Perry A, MacDonald TJ, Hernáiz Driever P, Bendel AE, Bowers DC, McCowage G, Chintagumpala MM, Cohn R, Hassall T, Fleischhack G, Eggen T, Wesenberg F, Feychting M, Lannering B, Schüz J, Johansen C, Andersen TV, Röösli M, Kuehni CE, Grotzer M, Kjaerheim K, Monoranu CM, Archer TC, Duke E, Pomeroy SL, Shelagh R, Frank S, Sumerauer D, Scheurlen W, Ryzhova MV, Milde T, Kratz CP, Samuel D, Zhang J, Solomon DA, Marra M, Eils R, Bartram CR, von Hoff K, Rutkowski S, Ramaswamy V, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Malkin D, Gajjar A, Korbel JO, Pfister SM. Waszak SM, et al. Lancet Oncol. 2018 Jun;19(6):785-798. doi: 10.1016/S1470-2045(18)30242-0. Epub 2018 May 9. Lancet Oncol. 2018. PMID: 29753700 Free PMC article.
DNA methylation profiling was done to determine consensus molecular subgroups: WNT (MB(WNT)), SHH (MB(SHH)), group 3 (MB(Group3)), and group 4 (MB(Group4)). Medulloblastoma predisposition genes were predicted on the basis of rare variant burden tests against controls witho …
DNA methylation profiling was done to determine consensus molecular subgroups: WNT (MB(WNT)), SHH (MB(SHH)), group 3 (MB(Group3)), and group …
Tumor antigens in glioma.
Nejo T, Yamamichi A, Almeida ND, Goretsky YE, Okada H. Nejo T, et al. Semin Immunol. 2020 Feb;47:101385. doi: 10.1016/j.smim.2020.101385. Epub 2020 Feb 6. Semin Immunol. 2020. PMID: 32037183 Review.
Still, the paucity of effective antigen targets remains a significant obstacle in safely and effectively treating glioblastoma and other malignant gliomas with relatively low mutation loads. In this review, we highlight the current understanding of and development of immun …
Still, the paucity of effective antigen targets remains a significant obstacle in safely and effectively treating glioblastoma and other mal …
Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures.
Hu LS, D'Angelo F, Weiskittel TM, Caruso FP, Fortin Ensign SP, Blomquist MR, Flick MJ, Wang L, Sereduk CP, Meng-Lin K, De Leon G, Nespodzany A, Urcuyo JC, Gonzales AC, Curtin L, Lewis EM, Singleton KW, Dondlinger T, Anil A, Semmineh NB, Noviello T, Patel RA, Wang P, Wang J, Eschbacher JM, Hawkins-Daarud A, Jackson PR, Grunfeld IS, Elrod C, Mazza GL, McGee SC, Paulson L, Clark-Swanson K, Lassiter-Morris Y, Smith KA, Nakaji P, Bendok BR, Zimmerman RS, Krishna C, Patra DP, Patel NP, Lyons M, Neal M, Donev K, Mrugala MM, Porter AB, Beeman SC, Jensen TR, Schmainda KM, Zhou Y, Baxter LC, Plaisier CL, Li J, Li H, Lasorella A, Quarles CC, Swanson KR, Ceccarelli M, Iavarone A, Tran NL. Hu LS, et al. Nat Commun. 2023 Sep 28;14(1):6066. doi: 10.1038/s41467-023-41559-1. Nat Commun. 2023. PMID: 37770427 Free PMC article.
Whole exome and RNA sequencing uncover unique genomic alterations to unresectable invasive NE tumor, including subclonal events, which inform genomic models predictive of geographic evolution. Infiltrative NE tumor is alternatively enriched with tumor cells exhibiting neur …
Whole exome and RNA sequencing uncover unique genomic alterations to unresectable invasive NE tumor, including subclonal events, which infor …
Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asian populations.
Mo Z, Xin J, Chai R, Woo PYM, Chan DTM, Wang J. Mo Z, et al. Cancer Biol Med. 2022 Nov 1;19(10):1440-59. doi: 10.20892/j.issn.2095-3941.2022.0418. Cancer Biol Med. 2022. PMID: 36350002 Free PMC article. Review.
Overall, we observed a lower glioma incidence in East Asians than in Whites; notably, patients with glioblastoma had significantly younger ages of onset and longer overall survival than the Whites. ...Although the somatic mutational profiles of gliomas betwee …
Overall, we observed a lower glioma incidence in East Asians than in Whites; notably, patients with glioblastoma had significa …
Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.
Howell AE, Robinson JW, Wootton RE, McAleenan A, Tsavachidis S, Ostrom QT, Bondy M, Armstrong G, Relton C, Haycock P, Martin RM, Zheng J, Kurian KM. Howell AE, et al. BMC Cancer. 2020 Jun 3;20(1):508. doi: 10.1186/s12885-020-06967-2. BMC Cancer. 2020. PMID: 32493226 Free PMC article.
RESULTS: Our systematic search identified 36 risk factors that could be proxied using genetic variants. Using MR, we found evidence that four genetically predicted traits increased risk of glioma, glioblastoma or non-glioblastoma: longer leukocyte telomere length, l …
RESULTS: Our systematic search identified 36 risk factors that could be proxied using genetic variants. Using MR, we found evidence that fou …
Dynamic susceptibility contrast and diffusion-weighted MRI in posterior fossa pilocytic astrocytoma and medulloblastoma.
Kurokawa R, Umemura Y, Capizzano A, Kurokawa M, Baba A, Holmes A, Kim J, Ota Y, Srinivasan A, Moritani T. Kurokawa R, et al. J Neuroimaging. 2022 May;32(3):511-520. doi: 10.1111/jon.12962. Epub 2022 Jan 7. J Neuroimaging. 2022. PMID: 34997668
RESULTS: The MB group showed a significantly higher nrCBV and nrCBF (nrCBV: 1.69 [0.93-4.23] vs. 0.95 [range, 0.37-2.28], p = .0032; nrCBF: 1.62 [0.93-3.16] vs. 1.07 [0.46-2.26], p = .0084) and significantly lower nADCmean and nADCmin (nADCmean: 0.97 [0.70- …
RESULTS: The MB group showed a significantly higher nrCBV and nrCBF (nrCBV: 1.69 [0.93-4.23] vs. 0.95 [range, 0.37-2.28], p = .0032; …
IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
Chen X, Liu J, Li Y, Zeng Y, Wang F, Cheng Z, Duan H, Pan G, Yang S, Chen Y, Li Q, Shen X, Li Y, Qin Z, Chen J, Huang Y, Wang X, Lu Y, Shu M, Zhang Y, Wang G, Li K, Lin X, Xing F, Zhang H. Chen X, et al. Nat Commun. 2023 Oct 25;14(1):6781. doi: 10.1038/s41467-023-42545-3. Nat Commun. 2023. PMID: 37880243 Free PMC article.
Here, we discover that IDH1 mutation inhibits virus-induced interferon (IFN) antiviral responses in glioma cells. Mechanistically, D2HG produced by mutant IDH1 enhances the binding of DNMT1 to IRF3/7 promoters such that IRF3/7 are downregulated, leading to impaired type I …
Here, we discover that IDH1 mutation inhibits virus-induced interferon (IFN) antiviral responses in glioma cells. Mechanistically, D2 …
541 results