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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1963 2
1964 1
1965 2
1967 7
1968 6
1969 11
1970 18
1971 16
1972 20
1973 37
1974 29
1975 77
1976 76
1977 47
1978 53
1979 91
1980 72
1981 70
1982 76
1983 88
1984 110
1985 154
1986 147
1987 135
1988 200
1989 189
1990 222
1991 274
1992 292
1993 323
1994 351
1995 344
1996 454
1997 418
1998 499
1999 527
2000 551
2001 677
2002 718
2003 844
2004 923
2005 1127
2006 1328
2007 1476
2008 1639
2009 1796
2010 2013
2011 2068
2012 2276
2013 2499
2014 2719
2015 2951
2016 2853
2017 3010
2018 3105
2019 3090
2020 3329
2021 3032
2022 2430
2023 2115
2024 1104

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48,385 results

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Quoted phrase not found in phrase index: "Glucose metabolism disease"
Page 1
Pathophysiology of Type 2 Diabetes Mellitus.
Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Ostolaza H, Martín C. Galicia-Garcia U, et al. Int J Mol Sci. 2020 Aug 30;21(17):6275. doi: 10.3390/ijms21176275. Int J Mol Sci. 2020. PMID: 32872570 Free PMC article. Review.
Because insulin release and activity are essential processes for glucose homeostasis, the molecular mechanisms involved in the synthesis and release of insulin, as well as in its detection are tightly regulated. Defects in any of the mechanisms involved in these processes …
Because insulin release and activity are essential processes for glucose homeostasis, the molecular mechanisms involved in the synthe …
The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation.
Poznyak A, Grechko AV, Poggio P, Myasoedova VA, Alfieri V, Orekhov AN. Poznyak A, et al. Int J Mol Sci. 2020 Mar 6;21(5):1835. doi: 10.3390/ijms21051835. Int J Mol Sci. 2020. PMID: 32155866 Free PMC article. Review.
Insulin is an important anabolic hormone, and its deficiency leads to various metabolic abnormalities in proteins, lipids, and carbohydrates. Atherosclerosis develops as a result of a multistep process ultimately leading to cardiovascular disease associated with hig …
Insulin is an important anabolic hormone, and its deficiency leads to various metabolic abnormalities in proteins, lipids, and carboh …
Fructose metabolism and metabolic disease.
Hannou SA, Haslam DE, McKeown NM, Herman MA. Hannou SA, et al. J Clin Invest. 2018 Feb 1;128(2):545-555. doi: 10.1172/JCI96702. Epub 2018 Feb 1. J Clin Invest. 2018. PMID: 29388924 Free PMC article. Review.
Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly har …
Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their asso …
Sex differences in cardiometabolic disorders.
Gerdts E, Regitz-Zagrosek V. Gerdts E, et al. Nat Med. 2019 Nov;25(11):1657-1666. doi: 10.1038/s41591-019-0643-8. Epub 2019 Nov 7. Nat Med. 2019. PMID: 31700185 Review.
The prevalence of cardiometabolic disorders in both women and men has increased worldwide and is linked to a rise in obesity and obesity-associated associated clustering of other cardiometabolic risk factors such as hypertension, impaired glucose regulation and dyslipidemi …
The prevalence of cardiometabolic disorders in both women and men has increased worldwide and is linked to a rise in obesity and obesity-ass …
Fructose and hepatic insulin resistance.
Softic S, Stanhope KL, Boucher J, Divanovic S, Lanaspa MA, Johnson RJ, Kahn CR. Softic S, et al. Crit Rev Clin Lab Sci. 2020 Aug;57(5):308-322. doi: 10.1080/10408363.2019.1711360. Epub 2020 Jan 14. Crit Rev Clin Lab Sci. 2020. PMID: 31935149 Free PMC article. Review.
This appears to be mediated by reduced insulin receptor and insulin receptor substrate 2 (IRS2) expression, increased protein-tyrosine phosphatase 1B (PTP1b) activity, whereas knockdown of ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, increased ins …
This appears to be mediated by reduced insulin receptor and insulin receptor substrate 2 (IRS2) expression, increased protein-tyrosine phosp …
Circadian physiology of metabolism.
Panda S. Panda S. Science. 2016 Nov 25;354(6315):1008-1015. doi: 10.1126/science.aah4967. Science. 2016. PMID: 27885007 Free PMC article. Review.
Experimental animal models and epidemiological data indicate that chronic circadian rhythm disruption increases the risk of metabolic diseases. Conversely, time-restricted feeding, which imposes daily cycles of feeding and fasting without caloric reduction, sustains …
Experimental animal models and epidemiological data indicate that chronic circadian rhythm disruption increases the risk of metabolic …
Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy.
Garaulet M, Qian J, Florez JC, Arendt J, Saxena R, Scheer FAJL. Garaulet M, et al. Trends Endocrinol Metab. 2020 Mar;31(3):192-204. doi: 10.1016/j.tem.2019.11.011. Epub 2020 Jan 1. Trends Endocrinol Metab. 2020. PMID: 31901302 Free PMC article. Review.
The past decade has witnessed a revival of interest in the hormone melatonin, partly attributable to the discovery that genetic variation in MTNR1B - the melatonin receptor gene - is a risk factor for impaired fasting glucose and type 2 diabetes (T2D). Despite intensive in …
The past decade has witnessed a revival of interest in the hormone melatonin, partly attributable to the discovery that genetic variation in …
Berberine and Its Role in Chronic Disease.
Cicero AF, Baggioni A. Cicero AF, et al. Adv Exp Med Biol. 2016;928:27-45. doi: 10.1007/978-3-319-41334-1_2. Adv Exp Med Biol. 2016. PMID: 27671811 Review.
Moreover, preliminary clinical evidence suggest the ability of berberine to reduce endothelial inflammation improving vascular health, even in patients already affected by cardiovascular diseases. Altogether the available evidences suggest a possible application of berberi …
Moreover, preliminary clinical evidence suggest the ability of berberine to reduce endothelial inflammation improving vascular health, even …
Insulin signalling and GLUT4 trafficking in insulin resistance.
van Gerwen J, Shun-Shion AS, Fazakerley DJ. van Gerwen J, et al. Biochem Soc Trans. 2023 Jun 28;51(3):1057-1069. doi: 10.1042/BST20221066. Biochem Soc Trans. 2023. PMID: 37248992 Free PMC article. Review.
Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining whole-body glucose homeostasis. ...Impaired insulin-stimulated GLUT4 translocation in these tissues underlies insulin resistance, which is a major risk factor for type 2 diabet …
Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining whole-body glucose homeostasis. ...I …
Role of bile acids and bile acid receptors in metabolic regulation.
Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Lefebvre P, et al. Physiol Rev. 2009 Jan;89(1):147-91. doi: 10.1152/physrev.00010.2008. Physiol Rev. 2009. PMID: 19126757 Free article. Review.
The incidence of the metabolic syndrome has taken epidemic proportions in the past decades, contributing to an increased risk of cardiovascular disease and diabetes. ...A cross-talk between BA and glucose metabolism was recently identified, implicating …
The incidence of the metabolic syndrome has taken epidemic proportions in the past decades, contributing to an increased risk of card …
48,385 results
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