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1989 1
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Page 1
The Oskar Fehr Lecture.
Weiss JS. Weiss JS. Klin Monbl Augenheilkd. 2016 Jun;233(6):708-12. doi: 10.1055/s-0042-100735. Epub 2016 Jun 17. Klin Monbl Augenheilkd. 2016. PMID: 27315290 English.
The impact of systemic cholesterol metabolism on other diseases is reviewed. RESULTS: Corneal findings in SCD are predictable on the basis of patient age. All patients develop progressive corneal haze because of abnormal deposition of corneal lipid, but only half of patien …
The impact of systemic cholesterol metabolism on other diseases is reviewed. RESULTS: Corneal findings in SCD are predictable on the …
Exacerbation of Granular Corneal Dystrophy Type 2 After Small Incision Lenticule Extraction.
Kwak JJ, Yoon SH, Seo KY, Kim TI, Lee HK, Stulting RD, Kim EK. Kwak JJ, et al. Cornea. 2021 Apr;40(4):519-524. doi: 10.1097/ICO.0000000000002655. Cornea. 2021. PMID: 33560675 Free PMC article.
METHODS: Slit-lamp photography and Fourier domain optical coherence tomography were used to document the clinical course and appearance of the corneas in a patient with genetically determined GCD2 who underwent unilateral SMILE in the right eye. ...
METHODS: Slit-lamp photography and Fourier domain optical coherence tomography were used to document the clinical course and appearan …
Mutation analysis of TGFBI and KRT12 in a case of concomitant keratoconus and granular corneal dystrophy.
Du X, Chen P, Sun D. Du X, et al. Graefes Arch Clin Exp Ophthalmol. 2017 Sep;255(9):1779-1786. doi: 10.1007/s00417-017-3699-5. Epub 2017 May 31. Graefes Arch Clin Exp Ophthalmol. 2017. PMID: 28567551
A heterozygous TGFBI mutation in exon 4 (c.370G > A) was identified in the proband, which was predicted to generate a missense mutation (p.R124H). The mutation also existed in his father and grandmother. A heterozygous KRT12 mutation in exon 8 (c.1456-1457ins GTA) was i …
A heterozygous TGFBI mutation in exon 4 (c.370G > A) was identified in the proband, which was predicted to generate a missense mut …
The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults.
Nita M, Grzybowski A. Nita M, et al. Oxid Med Cell Longev. 2016;2016:3164734. doi: 10.1155/2016/3164734. Epub 2016 Jan 10. Oxid Med Cell Longev. 2016. PMID: 26881021 Free PMC article. Review.
ROS promote apoptosis of vascular and neuronal cells and stimulate inflammation and pathological angiogenesis in the course of diabetic retinopathy. ROS are associated with the pathophysiological parainflammation and autophagy process in the course of the age-relate …
ROS promote apoptosis of vascular and neuronal cells and stimulate inflammation and pathological angiogenesis in the course of diabet …
Corneal Dystrophy Mutations Drive Pathogenesis by Targeting TGFBIp Stability and Solubility in a Latent Amyloid-forming Domain.
Stenvang M, Schafer NP, Malmos KG, Pérez AW, Niembro O, Sormanni P, Basaiawmoit RV, Christiansen G, Andreasen M, Otzen DE. Stenvang M, et al. J Mol Biol. 2018 Apr 13;430(8):1116-1140. doi: 10.1016/j.jmb.2018.03.001. Epub 2018 Mar 7. J Mol Biol. 2018. PMID: 29524512
Thus, TGFBIp aggregation is driven by mutations that despite their physico-chemical diversity target either the stability or solubility of Fas1-4 in predictable ways, suggesting straightforward general therapeutic strategies....
Thus, TGFBIp aggregation is driven by mutations that despite their physico-chemical diversity target either the stability or solubility of F …
Biochemical properties and aggregation propensity of transforming growth factor-induced protein (TGFBIp) and the amyloid forming mutants.
Lakshminarayanan R, Chaurasia SS, Murugan E, Venkatraman A, Chai SM, Vithana EN, Beuerman RW, Mehta JS. Lakshminarayanan R, et al. Ocul Surf. 2015 Jan;13(1):9-25. doi: 10.1016/j.jtos.2014.04.003. Epub 2014 Oct 8. Ocul Surf. 2015. PMID: 25557343 Review.
We describe the relative aggregation rates of lattice corneal dystrophy (LCD) and granular corneal dystrophy (GCD2) mutants using the three-parameter model, which is based on intrinsic properties of polypeptide chains. The predictive power of this model is compared with tw …
We describe the relative aggregation rates of lattice corneal dystrophy (LCD) and granular corneal dystrophy (GCD2) mutants using the three- …
39 results