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Iranian patients with hemoglobin H disease: genotype-phenotype correlation.
Paridar M, Azizi E, Keikhaei B, Takhviji V, Baluchi I, Khosravi A. Paridar M, et al. Mol Biol Rep. 2019 Oct;46(5):5041-5048. doi: 10.1007/s11033-019-04955-9. Epub 2019 Jul 4. Mol Biol Rep. 2019. PMID: 31273613
A total of ten different alpha-globin (alpha-globin) mutations were observed in patients which --(MED), being the most common mutation (26.27%), followed by -alpha(3.7) (24.37%) and alpha(polyA2(A>G)) (18.12%). ...
A total of ten different alpha-globin (alpha-globin) mutations were observed in patients which --(MED), being the most common mutatio …
Molecular Basis and Hematologic Phenotype of Hemoglobin H Disease Combined with Two Rare beta-Globin Mutations.
Qiu Y, Wei S, Hou W, Lai K, Zhu H, Li W, Li Q, Yang Z, Shu Q, Chen P, Mo W. Qiu Y, et al. Hemoglobin. 2023 Nov;47(2):52-55. doi: 10.1080/03630269.2023.2219008. Epub 2023 Jun 12. Hemoglobin. 2023. PMID: 37309066
In area where alpha-thalassemia and beta-thalassemia are prevalent, the coinheritance of hemoglobin H disease (Hb H disease) and beta-thalassemia are not uncommon and could result in complex thalassemia intermedia syndromes. ...In both cases, the level of Hb …
In area where alpha-thalassemia and beta-thalassemia are prevalent, the coinheritance of hemoglobin H disease (Hb H dis …
Bone Mineral Density and Dickkopf-1 in Adolescents with Non-Deletional Hemoglobin H Disease.
Wiromrat P, Rattanathongkom A, Laoaroon N, Suwannaying K, Komwilaisak P, Panamonta O, Wongsurawat N, Nasomyont N. Wiromrat P, et al. J Clin Densitom. 2023 Jul-Sep;26(3):101379. doi: 10.1016/j.jocd.2023.101379. Epub 2023 Apr 26. J Clin Densitom. 2023. PMID: 37147222
Therefore, we aimed to determine the prevalence of low BMD and the association between BMD and serum dickkopf-1 in adolescents with non-deletional hemoglobin H disease, a form of alpha-thalassemia whose severity is comparable to beta-thalassemia intermedia. . …
Therefore, we aimed to determine the prevalence of low BMD and the association between BMD and serum dickkopf-1 in adolescents with non-dele …
Comparative plasma protein profiling of hemoglobin H disease.
Leecharoenkiat K, Sornjai W, Khungwanmaythawee K, Paemanee A, Chaichana C, Roytrakul S, Fucharoen S, Svasti S, Smith DR. Leecharoenkiat K, et al. Dis Markers. 2014;2014:340214. doi: 10.1155/2014/340214. Epub 2014 Jun 15. Dis Markers. 2014. PMID: 25024506 Free PMC article.
The identification of differentially expressed proteins may lead to a better understanding of the biological events underlying the clinical presentation of HbH and HbH-CS patients and can have application as hemolytic markers or severity predictors....
The identification of differentially expressed proteins may lead to a better understanding of the biological events underlying the clinical …
Association of hemoglobin H (HbH) disease with hemoglobin A1c and glycated albumin in diabetic and non-diabetic patients.
He D, Kuang W, Yang X, Xu M. He D, et al. Clin Chem Lab Med. 2021 Jan 14;59(6):1127-1132. doi: 10.1515/cclm-2020-1563. Print 2021 May 26. Clin Chem Lab Med. 2021. PMID: 33554549
HbA(1c) was measured using five methods, including two systems based on cation-exchange high-performance liquid chromatography (Variant II Turbo 2.0 and Bio-Rad D100), a capillary zone electrophoresis method (Capillarys 3 TERA), a boronate affinity HPLC method (Premier Hb9210), a …
HbA(1c) was measured using five methods, including two systems based on cation-exchange high-performance liquid chromatography (Variant II T …
Proteomic analysis of hemoglobin H-constant spring (Hb H-CS) erythroblasts.
Sriiam S, Leecharoenkiat A, Lithanatudom P, Wannatung T, Svasti S, Fucharoen S, Svasti J, Chokchaichamnankit D, Srisomsap C, Smith DR. Sriiam S, et al. Blood Cells Mol Dis. 2012 Feb 15;48(2):77-85. doi: 10.1016/j.bcmd.2011.11.004. Epub 2011 Dec 7. Blood Cells Mol Dis. 2012. PMID: 22154201
Hemoglobin H disease (Hb H) arises through the loss or dysfunction of three of the four alpha globin genes through the co-inheritance of either gross gene deletions or an abnormal hemoglobin which causes a non-deletional loss of alpha-globin expression. ...In …
Hemoglobin H disease (Hb H) arises through the loss or dysfunction of three of the four alpha globin genes through the …
Epidemiology of clinically significant forms of alpha- and beta-thalassemia: A global map of evidence and gaps.
Musallam KM, Lombard L, Kistler KD, Arregui M, Gilroy KS, Chamberlain C, Zagadailov E, Ruiz K, Taher AT. Musallam KM, et al. Am J Hematol. 2023 Sep;98(9):1436-1451. doi: 10.1002/ajh.27006. Epub 2023 Jun 26. Am J Hematol. 2023. PMID: 37357829
Embase, MEDLINE, and the Cochrane Library were searched for observational studies published January 1, 2000, to September 21, 2021. ...Across 23 population-based studies reporting clinically significant alpha-thalassemia (e.g., hemoglobin H disease and …
Embase, MEDLINE, and the Cochrane Library were searched for observational studies published January 1, 2000, to September 21, 2021. . …
Heterogeneity of hemoglobin H disease in childhood.
Lal A, Goldrich ML, Haines DA, Azimi M, Singer ST, Vichinsky EP. Lal A, et al. N Engl J Med. 2011 Feb 24;364(8):710-8. doi: 10.1056/NEJMoa1010174. N Engl J Med. 2011. PMID: 21345100 Free article.
BACKGROUND: Early diagnosis during newborn screening or infancy has enabled the observation of the natural history of hemoglobin H disease, a subtype of alpha-thalassemia. ...RESULTS: We identified 86 patients with hemoglobin H disease …
BACKGROUND: Early diagnosis during newborn screening or infancy has enabled the observation of the natural history of hemoglobin …
Analysis of the anemia characteristics in early pregnancy and outcomes of pregnant women with hemoglobin H disease.
Su JY, Chen Y, Chen HF, Tong JR, Wei YN, Huang LL, Deng L. Su JY, et al. Eur Rev Med Pharmacol Sci. 2023 Feb;27(3):1027-1032. doi: 10.26355/eurrev_202302_31198. Eur Rev Med Pharmacol Sci. 2023. PMID: 36808349 Free article.
RESULTS: A total of 13 cases of missing type (46.43%) and 15 cases of non-missing type (53.57%) were observed in the 28 cases of pregnant women with Hb H disease. The genotypes were as follows: 8 cases of -alpha3.7/--SEA (28.57%), 4 cases of -alpha4.2/--SEA (14.29%), 1 cas …
RESULTS: A total of 13 cases of missing type (46.43%) and 15 cases of non-missing type (53.57%) were observed in the 28 cases of preg …
Elevations of Thrombotic Biomarkers in Hemoglobin H Disease.
Chansai S, Fucharoen S, Fucharoen G, Jetsrisuparb A, Chumpia W. Chansai S, et al. Acta Haematol. 2018;139(1):47-51. doi: 10.1159/000486157. Epub 2018 Jan 18. Acta Haematol. 2018. PMID: 29402840

RESULTS: Significant increases in the levels of PS, ICAM-1, TNFalpha, beta-TG, and F1.2 were observed in both patient groups compared to normal controls (p < 0.01). CONCLUSION: This observation indicates blood coagulation, endothelial injury, chronic low-grade in

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RESULTS: Significant increases in the levels of PS, ICAM-1, TNFalpha, beta-TG, and F1.2 were observed in both patient groups compared …
38 results