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Hemophilia B: molecular pathogenesis and mutation analysis.
Goodeve AC. Goodeve AC. J Thromb Haemost. 2015 Jul;13(7):1184-95. doi: 10.1111/jth.12958. Epub 2015 May 18. J Thromb Haemost. 2015. PMID: 25851415 Free PMC article. Review.
Hemophilia B results from several different mechanisms, and those associated with hemophilia B Leyden, ribosome readthrough of nonsense mutations and apparently 'silent' changes that do not alter amino acid coding are explored. ...
Hemophilia B results from several different mechanisms, and those associated with hemophilia B Leyden, ribosome readthr …
The Molecular Basis of FIX Deficiency in Hemophilia B.
Shen G, Gao M, Cao Q, Li W. Shen G, et al. Int J Mol Sci. 2022 Mar 2;23(5):2762. doi: 10.3390/ijms23052762. Int J Mol Sci. 2022. PMID: 35269902 Free PMC article. Review.
Generally speaking, point mutations in the F9 promoter region result in hemophilia B Leyden, and those in the introns cause aberrant splicing. ...
Generally speaking, point mutations in the F9 promoter region result in hemophilia B Leyden, and those in the introns c …
First case report of hemophilia B Leyden in Japan.
Yamashita A, Nagae C, Mori M, Ashikaga T, Kojima T, Taki M. Yamashita A, et al. Int J Hematol. 2017 Jul;106(1):135-137. doi: 10.1007/s12185-017-2194-4. Epub 2017 Feb 7. Int J Hematol. 2017. PMID: 28168417
Hemophilia B Leyden is a unique subtype of hemophilia B, characterized by increasing factor IX activity (FIX:C) after puberty and a lower normal range of FIX:C throughout adulthood. ...This mutation has been reported previously as the Leyden mutation. Althoug …
Hemophilia B Leyden is a unique subtype of hemophilia B, characterized by increasing factor IX activity (FIX:C) after p …