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261 results

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Quoted phrase not found in phrase index: "Hepatorenocardiac degenerative fibrosis"
Page 1
Sinus Node Dysfunction.
Hawks MK, Paul MLB, Malu OO. Hawks MK, et al. Am Fam Physician. 2021 Aug 1;104(2):179-185. Am Fam Physician. 2021. PMID: 34383451 Free article. Review.
The causes of sinus node dysfunction are intrinsic (e.g., degenerative idiopathic fibrosis, cardiac remodeling) or extrinsic (e.g., medications, metabolic abnormalities) to the sinoatrial node. ...The patient's inability to reach a heart rate of at least 80% of thei …
The causes of sinus node dysfunction are intrinsic (e.g., degenerative idiopathic fibrosis, cardiac remodeling) or extrinsic ( …
Dose-Escalation Study of Systemically Delivered rAAVrh74.MHCK7.micro-dystrophin in the mdx Mouse Model of Duchenne Muscular Dystrophy.
Potter RA, Griffin DA, Heller KN, Peterson EL, Clark EK, Mendell JR, Rodino-Klapac LR. Potter RA, et al. Hum Gene Ther. 2021 Apr;32(7-8):375-389. doi: 10.1089/hum.2019.255. Epub 2021 Feb 18. Hum Gene Ther. 2021. PMID: 33397205 Free PMC article. Clinical Trial.
Duchenne muscular dystrophy (DMD) is a rare, X-linked, fatal, degenerative neuromuscular disease caused by mutations in the DMD gene. ...Significant reduction in central nucleation was also observed, although complete normalization to WT was not seen. No vector-asso …
Duchenne muscular dystrophy (DMD) is a rare, X-linked, fatal, degenerative neuromuscular disease caused by mutations in the DMD gene. …
Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F. Si S, et al. Front Immunol. 2021 Jul 27;12:720876. doi: 10.3389/fimmu.2021.720876. eCollection 2021. Front Immunol. 2021. PMID: 34386016 Free PMC article.
BACKGROUND: C-reactive protein (CRP) has been used as a biomarker of chronic low-grade inflammation in observational studies. We aimed to determine whether genetically determined CRP was associated with hundreds of human phenotypes to guide anti-inflammatory interventions. …
BACKGROUND: C-reactive protein (CRP) has been used as a biomarker of chronic low-grade inflammation in observational studies. We aime …
Long-Term Sequelae of COVID-19 in Experimental Mice.
Paidas MJ, Cosio DS, Ali S, Kenyon NS, Jayakumar AR. Paidas MJ, et al. Mol Neurobiol. 2022 Oct;59(10):5970-5986. doi: 10.1007/s12035-022-02932-1. Epub 2022 Jul 13. Mol Neurobiol. 2022. PMID: 35831558 Free PMC article.
Hearts showed severe interstitial edema, vascular congestion and dilation, nucleated red blood cells (RBCs), RBCs infiltrating between degenerative myocardial fibers, inflammatory cells and apoptotic bodies and acute myocyte necrosis, hypertrophy, and fibrosis. Long …
Hearts showed severe interstitial edema, vascular congestion and dilation, nucleated red blood cells (RBCs), RBCs infiltrating between de …
Arrhythmic Mitral Valve Prolapse With Only Mild or Moderate Mitral Regurgitation: Characterization of Myocardial Substrate.
Miller MA, Devesa A, Robson PM, Liao SL, Pyzik R, El-Eshmawi A, Boateng P, Pandis D, Dukkipati SR, Reddy VY, Adams DH, Fayad ZA, Trivieri MG. Miller MA, et al. JACC Clin Electrophysiol. 2023 Aug;9(8 Pt 3):1709-1716. doi: 10.1016/j.jacep.2023.04.011. Epub 2023 May 24. JACC Clin Electrophysiol. 2023. PMID: 37227360
BACKGROUND: Sustained ventricular tachycardia and sudden cardiac death due to degenerative mitral valve prolapse (MVP) can occur in the absence of severe mitral regurgitation (MR). ...Abnormal T1, T2 and extracellular volume (ECV) values were observed in 58% (n = 7) …
BACKGROUND: Sustained ventricular tachycardia and sudden cardiac death due to degenerative mitral valve prolapse (MVP) can occur in t …
Long telomeres and cancer risk: the price of cellular immortality.
McNally EJ, Luncsford PJ, Armanios M. McNally EJ, et al. J Clin Invest. 2019 Aug 5;129(9):3474-3481. doi: 10.1172/JCI120851. eCollection 2019 Aug 5. J Clin Invest. 2019. PMID: 31380804 Free PMC article. Review.
The genetic basis of these short and long telomere syndromes may be linked to mutations in the same genes, such as the telomerase reverse transcriptase (TERT), but through differential effects on telomere length. Short telomere syndromes have a predominant degenerative phe …
The genetic basis of these short and long telomere syndromes may be linked to mutations in the same genes, such as the telomerase reverse tr …
Ivabradine could not decrease mitral regurgitation triggered atrial fibrosis and fibrillation compared with carvedilol.
Lee WC, Lin YW, Shih JY, Chen ZC, Wu NC, Chang WT. Lee WC, et al. ESC Heart Fail. 2024 Feb;11(1):251-260. doi: 10.1002/ehf2.14577. Epub 2023 Nov 14. ESC Heart Fail. 2024. PMID: 37963437 Free PMC article. Clinical Trial.
It is frequently prescribed to patients with HF who have a suboptimal response or intolerance to beta-blockers. Degenerative mitral regurgitation (MR) is a valvular heart disease often associated with the development of HF and atrial fibrillation (AF). ...MR + Carvedilol a …
It is frequently prescribed to patients with HF who have a suboptimal response or intolerance to beta-blockers. Degenerative mitral r …
Telomeres and age-related disease: how telomere biology informs clinical paradigms.
Armanios M. Armanios M. J Clin Invest. 2013 Mar;123(3):996-1002. doi: 10.1172/JCI66370. Epub 2013 Mar 1. J Clin Invest. 2013. PMID: 23454763 Free PMC article. Review.
Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis …
Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the …
Revealing the novel autophagy-related genes for ligamentum flavum hypertrophy in patients and mice model.
Li P, Fei CS, Chen YL, Chen ZS, Lai ZM, Tan RQ, Yu YP, Xiang X, Dong JL, Zhang JX, Wang L, Zhang ZM. Li P, et al. Front Immunol. 2022 Oct 5;13:973799. doi: 10.3389/fimmu.2022.973799. eCollection 2022. Front Immunol. 2022. PMID: 36275675 Free PMC article.
BACKGROUND: Fibrosis is a core pathological factor of ligamentum flavum hypertrophy (LFH) resulting in degenerative lumbar spinal stenosis. Autophagy plays a vital role in multi-organ fibrosis. However, autophagy has not been reported to be involved in the pa …
BACKGROUND: Fibrosis is a core pathological factor of ligamentum flavum hypertrophy (LFH) resulting in degenerative lumbar spi …
The toxic oil syndrome.
James TN. James TN. Clin Cardiol. 1994 Sep;17(9):463-70. doi: 10.1002/clc.4960170902. Clin Cardiol. 1994. PMID: 8001309 Free article. Review.
Because scleroderma involves the heart, an examination was made of the small and large coronary arteries, the neural structures, and the conduction system from 11 victims dying with the toxic oil syndrome. Dense fibrosis, atrionodal junctional hemorrhages, and cystic degen …
Because scleroderma involves the heart, an examination was made of the small and large coronary arteries, the neural structures, and the con …
261 results