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Biological and Genetic Features of Neuroblastoma and Their Clinical Importance.
Aygun N. Aygun N. Curr Pediatr Rev. 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. Curr Pediatr Rev. 2018. PMID: 29380702 Review.
Neuroblastoma usually occurs sporadically, but familial cases are also observed. ALK and PHOX2B germline mutations can cause hereditary neuroblastoma, while a common genetic variation in chromosome 6p22 is associated to sporadic neuroblastoma. ...
Neuroblastoma usually occurs sporadically, but familial cases are also observed. ALK and PHOX2B germline mutations can cause hered …
Neonatal neuroblastoma.
Fisher JPH, Tweddle DA. Fisher JPH, et al. Semin Fetal Neonatal Med. 2012 Aug;17(4):207-215. doi: 10.1016/j.siny.2012.05.002. Epub 2012 Jun 4. Semin Fetal Neonatal Med. 2012. PMID: 22673527 Review.
Universal mass screening for neuroblastoma is not indicated but targeted screening of infants at risk of hereditary neuroblastoma with germline ALK or PHOX2B mutations is appropriate. Future studies will be aimed at observing more patients without adverse gen …
Universal mass screening for neuroblastoma is not indicated but targeted screening of infants at risk of hereditary neuroblastoma …
Novel ALK inhibitor AZD3463 inhibits neuroblastoma growth by overcoming crizotinib resistance and inducing apoptosis.
Wang Y, Wang L, Guan S, Cao W, Wang H, Chen Z, Zhao Y, Yu Y, Zhang H, Pang JC, Huang SL, Akiyama Y, Yang Y, Sun W, Xu X, Shi Y, Zhang H, Kim ES, Muscal JA, Lu F, Yang J. Wang Y, et al. Sci Rep. 2016 Jan 20;6:19423. doi: 10.1038/srep19423. Sci Rep. 2016. PMID: 26786851 Free PMC article.
Germline ALK activating mutations are responsible for the majority of hereditary neuroblastoma and somatic ALK activating mutations are also frequently observed in sporadic cases of advanced NB. ...
Germline ALK activating mutations are responsible for the majority of hereditary neuroblastoma and somatic ALK activating muta …