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Page 1
The psychopharmacology of Huntington disease.
Petersén Å, Weydt P. Petersén Å, et al. Handb Clin Neurol. 2019;165:179-189. doi: 10.1016/B978-0-444-64012-3.00010-1. Handb Clin Neurol. 2019. PMID: 31727211 Review.
Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded cytosine-adenine-guanine triplet repeat in the huntingtin gene. ...In this chapter, we provide an overview of the complex clinical manifestations of HD and the com …
Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded cytosine-adenine-guanine tripl …
Screening of therapeutic strategies for Huntington's disease in YAC128 transgenic mice.
Gil-Mohapel JM. Gil-Mohapel JM. CNS Neurosci Ther. 2012 Jan;18(1):77-86. doi: 10.1111/j.1755-5949.2011.00246.x. CNS Neurosci Ther. 2012. PMID: 21501423 Free PMC article. Review.
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an unstable expansion of cytosine-adenine-guanine (CAG) repeats in the HD gene. ...The insights obtained from these and future studies will help identify potential candidates for …
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an unstable expansion of cytosine-adenin …
Update on Huntington's disease: advances in care and emerging therapeutic options.
Zielonka D, Mielcarek M, Landwehrmeyer GB. Zielonka D, et al. Parkinsonism Relat Disord. 2015 Mar;21(3):169-78. doi: 10.1016/j.parkreldis.2014.12.013. Epub 2014 Dec 19. Parkinsonism Relat Disord. 2015. PMID: 25572500 Review.
INTRODUCTION: Huntington's disease (HD) is the most common hereditary neurodegenerative disorder. Despite the fact that both the gene and the mutation causing this monogenetic disorder were identified more than 20 years ago, disease-modifying therapies for HD …
INTRODUCTION: Huntington's disease (HD) is the most common hereditary neurodegenerative disorder. Despite the fact that …
Small molecule splicing modifiers with systemic HTT-lowering activity.
Bhattacharyya A, Trotta CR, Narasimhan J, Wiedinger KJ, Li W, Effenberger KA, Woll MG, Jani MB, Risher N, Yeh S, Cheng Y, Sydorenko N, Moon YC, Karp GM, Weetall M, Dakka A, Gabbeta V, Naryshkin NA, Graci JD, Tripodi T Jr, Southwell A, Hayden M, Colacino JM, Peltz SW. Bhattacharyya A, et al. Nat Commun. 2021 Dec 15;12(1):7299. doi: 10.1038/s41467-021-27157-z. Nat Commun. 2021. PMID: 34911927 Free PMC article.
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene. ...
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by expansion of cytosine-adenine-guanine (C …
Spinal muscular atrophy in the neonate.
Markowitz JA, Tinkle MB, Fischbeck KH. Markowitz JA, et al. J Obstet Gynecol Neonatal Nurs. 2004 Jan-Feb;33(1):12-20. doi: 10.1177/0884217503261125. J Obstet Gynecol Neonatal Nurs. 2004. PMID: 14971549 Review.
Spinal muscular atrophy (SMA) type I is an autosomal recessive disorder characterized by loss of lower motor neurons in the spinal cord. This severe hereditary neurodegenerative disorder is an important cause of morbidity in the neonate and the leading heredi …
Spinal muscular atrophy (SMA) type I is an autosomal recessive disorder characterized by loss of lower motor neurons in the spinal cord. Thi …
Current Pharmacological Approaches to Reduce Chorea in Huntington's Disease.
Coppen EM, Roos RA. Coppen EM, et al. Drugs. 2017 Jan;77(1):29-46. doi: 10.1007/s40265-016-0670-4. Drugs. 2017. PMID: 27988871 Free PMC article. Review.
There are currently no effective pharmacological agents available to stop or prevent the progression of Huntington's disease (HD), a rare hereditary neurodegenerative disorder. In addition to psychiatric symptoms and cognitive impairments, HD causes progressi …
There are currently no effective pharmacological agents available to stop or prevent the progression of Huntington's disease (HD), a rare …
Real-World Experience With Deutetrabenazine for Huntington Disease Chorea.
Curtis K, Sung V. Curtis K, et al. J Clin Pharmacol. 2024 Feb;64(2):178-181. doi: 10.1002/jcph.2336. Epub 2023 Aug 24. J Clin Pharmacol. 2024. PMID: 37565322 Review.
Huntington disease (HD) is a hereditary neurodegenerative disorder with a hallmark feature of chorea. ...In pivotal trials, deutetrabenazine seemed to have an improved safety and tolerability profile over tetrabenazine but real-world data to confirm this are …
Huntington disease (HD) is a hereditary neurodegenerative disorder with a hallmark feature of chorea. ...In pivotal tri …
Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics.
Blum D, Hourez R, Galas MC, Popoli P, Schiffmann SN. Blum D, et al. Lancet Neurol. 2003 Jun;2(6):366-74. doi: 10.1016/s1474-4422(03)00411-3. Lancet Neurol. 2003. PMID: 12849153 Review.
Huntington's disease (HD) is a devastating hereditary neurodegenerative disorder, the progression of which cannot be prevented by any neuroprotective approach, despite major advances in the understanding of its pathogenesis. ...Future pharmacological analysis …
Huntington's disease (HD) is a devastating hereditary neurodegenerative disorder, the progression of which cannot be pr …
Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1.
Singhal A, Szente L, Hildreth JEK, Song B. Singhal A, et al. Cell Death Dis. 2018 Oct 3;9(10):1019. doi: 10.1038/s41419-018-1056-1. Cell Death Dis. 2018. PMID: 30282967 Free PMC article.
Niemann-Pick type C (NPC) disease is a fatal hereditary neurodegenerative disorder characterized by a massive accumulation of cholesterol in lysosomes and late endosomes due to a defect in intracellular cholesterol trafficking. ...Studies showed that 2-hydrox …
Niemann-Pick type C (NPC) disease is a fatal hereditary neurodegenerative disorder characterized by a massive accumulat …
Enzyme replacement therapy attenuates disease progression in a canine model of late-infantile neuronal ceroid lipofuscinosis (CLN2 disease).
Katz ML, Coates JR, Sibigtroth CM, Taylor JD, Carpentier M, Young WM, Wininger FA, Kennedy D, Vuillemenot BR, O'Neill CA. Katz ML, et al. J Neurosci Res. 2014 Nov;92(11):1591-8. doi: 10.1002/jnr.23423. Epub 2014 Jun 17. J Neurosci Res. 2014. PMID: 24938720 Free PMC article.
Using a canine model of classical late-infantile neuronal ceroid lipofuscinosis (CLN2 disease), a study was conducted to evaluate the potential pharmacological activity of recombinant human tripeptidyl peptidase-1 (rhTPP1) enzyme replacement therapy administered directly to the c …
Using a canine model of classical late-infantile neuronal ceroid lipofuscinosis (CLN2 disease), a study was conducted to evaluate the potent …
14 results