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Quoted phrase not found in phrase index: "Hereditary factor XI deficiency disease"
Page 1
Disseminated intravascular coagulation.
Gando S, Levi M, Toh CH. Gando S, et al. Nat Rev Dis Primers. 2016 Jun 2;2:16037. doi: 10.1038/nrdp.2016.37. Nat Rev Dis Primers. 2016. PMID: 27250996 Review.
The main pathophysiological mechanisms of DIC are inflammatory cytokine-initiated activation of tissue factor-dependent coagulation, insufficient control of anticoagulant pathways and plasminogen activator inhibitor 1-mediated suppression of fibrinolysis. ...The Internatio …
The main pathophysiological mechanisms of DIC are inflammatory cytokine-initiated activation of tissue factor-dependent coagulation, …
TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis.
Huang Q, Wu D, Zhao J, Yan Z, Chen L, Guo S, Wang D, Yuan C, Wang Y, Liu X, Xing J. Huang Q, et al. EMBO J. 2022 Jun 1;41(11):e110324. doi: 10.15252/embj.2021110324. Epub 2022 Apr 22. EMBO J. 2022. PMID: 35451091 Free PMC article.
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFA …
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced …
Clinical Evaluation of Factor XIa Inhibitor Drugs: JACC Review Topic of the Week.
Harrington J, Piccini JP, Alexander JH, Granger CB, Patel MR. Harrington J, et al. J Am Coll Cardiol. 2023 Feb 28;81(8):771-779. doi: 10.1016/j.jacc.2022.11.057. J Am Coll Cardiol. 2023. PMID: 36813377 Free article. Review.
Factor XI/XIa (FXI/FXIa) represents a potential target for improved precision in anticoagulation because it is involved primarily in thrombus formation and plays a much smaller role in clotting and hemostasis. This suggests that the inhibition of FXI/XIa could preve …
Factor XI/XIa (FXI/FXIa) represents a potential target for improved precision in anticoagulation because it is involved primar …
Factor XI Deficiency.
Duga S, Salomon O. Duga S, et al. Semin Thromb Hemost. 2009 Jun;35(4):416-25. doi: 10.1055/s-0029-1225764. Epub 2009 Jul 13. Semin Thromb Hemost. 2009. PMID: 19598070 Review.
Severe factor XI (FXI) deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide. ...Herein, we present new observations related to clinic presentation, genotype-phenotype correlation, and treatment problems in patie …
Severe factor XI (FXI) deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide. . …
Factor XI deficiency.
Gomez K, Bolton-Maggs P. Gomez K, et al. Haemophilia. 2008 Nov;14(6):1183-9. doi: 10.1111/j.1365-2516.2008.01667.x. Epub 2008 Feb 27. Haemophilia. 2008. PMID: 18312365 Review.
Although factor XI (FXI) deficiency has a particularly high incidence in Ashkenazi Jews, it is now frequently diagnosed in other ethnic groups. This review gives an overview of the basic pathophysiology, clinical manifestations, and management of FXI defic …
Although factor XI (FXI) deficiency has a particularly high incidence in Ashkenazi Jews, it is now frequently diagnosed …
Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages.
Qu W, Zhou X, Jiang X, Xie X, Xu K, Gu X, Na R, Piao M, Xi X, Sun N, Wang X, Peng X, Xu J, Tian J, Zhang J, Guo J, Zhang M, Zhang Y, Pan Z, Wang K, Yu B, Sun B, Li S, Tian J. Qu W, et al. Arterioscler Thromb Vasc Biol. 2023 Nov;43(11):e468-e489. doi: 10.1161/ATVBAHA.123.319037. Epub 2023 Sep 28. Arterioscler Thromb Vasc Biol. 2023. PMID: 37767704
Therefore, it is essential to investigate the novel mechanism and molecules to reverse amino acid-mTORC1-autophagy signaling dysfunction in macrophages of patients with advanced atherosclerosis. METHODS: We observed that Gpr137b-ps (G-protein-coupled receptor 137B, pseudog …
Therefore, it is essential to investigate the novel mechanism and molecules to reverse amino acid-mTORC1-autophagy signaling dysfunction in …
Long-term Pegylated GH for Children With GH Deficiency: A Large, Prospective, Real-world Study.
Hou L, Huang K, Gong C, Luo F, Wei H, Liang L, Du H, Zhang J, Zhong Y, Chen R, Chen X, Pan J, Jin X, Zeng T, Liao W, Liu D, Lan D, Zhu S, Dong Z, Ma H, Yang Y, Xiong F, Lu P, Cheng S, Gu X, Jin R, Liu Y, Wu J, Xu X, Chen L, Dong Q, Pan H, Su Z, Liu L, Luo X, Ni S, Chen Z, Hu Y, Wang C, Liu J, Liu L, Lu B, Wang X, Wang Y, Yang F, Zhang M, Cao L, Liu G, Yao H, Zhan Y, Dai M, Li G, Li L, Liu Y, Wang K, Xiao Y, Zhang X, Dong J, Gu Z, Ying L, Huang F, Liu Y, Liu Z, Ye J, Zhao D, Hu X, Jiang Z, Ye K, Zhu H, Chen S, Chen X, Wan N, Xu Z, Yin Q, Zhang H, Huang X, Yin J, Zhang H, Li P, Yin P, Fu J, Luo X. Hou L, et al. J Clin Endocrinol Metab. 2023 Jul 14;108(8):2078-2086. doi: 10.1210/clinem/dgad039. J Clin Endocrinol Metab. 2023. PMID: 36669772 Free PMC article.
DESIGN: A prospective, observational, posttrial study (NCT03290235). SETTING, PARTICIPANTS AND INTERVENTION: Children with GHD were enrolled from 81 centers in China in 4 individual clinical trials and received weekly 0.2 mg/kg/wk (high-dose) or 0.1 to <0.2 mg/kg/wk (lo …
DESIGN: A prospective, observational, posttrial study (NCT03290235). SETTING, PARTICIPANTS AND INTERVENTION: Children with GHD were e …
The hemostatic role of factor XI.
Puy C, Rigg RA, McCarty OJ. Puy C, et al. Thromb Res. 2016 May;141 Suppl 2(Suppl 2):S8-S11. doi: 10.1016/S0049-3848(16)30354-1. Thromb Res. 2016. PMID: 27207433 Free PMC article. Review.
Coagulation factor (F)XI has been described as a component of the early phase of the contact pathway of blood coagulation, acting downstream of factor XII. ...Further complicating the picture, bleeding risk in FXI-deficient patients is difficult to predict …
Coagulation factor (F)XI has been described as a component of the early phase of the contact pathway of blood coagulation, act …
Rare bleeding disorders.
Peyvandi F, Bolton-Maggs PH, Batorova A, De Moerloose P. Peyvandi F, et al. Haemophilia. 2012 Jul;18 Suppl 4:148-53. doi: 10.1111/j.1365-2516.2012.02841.x. Haemophilia. 2012. PMID: 22726099 Review.
Rare bleeding disorders (RBDs) include the inherited deficiencies of fibrinogen, factor (F)II, FV, FV+FVIII, FVII, FX, FXI and FXIII. There have been remarkable advances in understanding the molecular profiles that lead to each type of coagulation factor deficien …
Rare bleeding disorders (RBDs) include the inherited deficiencies of fibrinogen, factor (F)II, FV, FV+FVIII, FVII, FX, FXI and FXIII. …
Factor XI as a Therapeutic Target.
Gailani D, Gruber A. Gailani D, et al. Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1316-22. doi: 10.1161/ATVBAHA.116.306925. Epub 2016 May 12. Arterioscler Thromb Vasc Biol. 2016. PMID: 27174099 Free PMC article. Review.
Work with animal models and results from epidemiological surveys of human populations support a role for factor XIa in thromboembolic disease. These data and the clinical observation that deficiency of factor XI, the zymogen of factor …
Work with animal models and results from epidemiological surveys of human populations support a role for factor XIa in thromboembolic …
220 results