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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1979 1
1993 1
1996 3
1997 1
1998 2
1999 6
2000 5
2001 8
2002 4
2003 1
2004 5
2005 4
2006 4
2007 3
2008 2
2009 3
2010 6
2011 2
2012 2
2013 1
2014 3
2015 5
2016 3
2017 2
2018 2
2019 5
2020 3
2021 1
2022 4
2023 2
2024 0

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84 results

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Page 1
Genetics, Cell Biology, and Pathophysiology of Pancreatitis.
Mayerle J, Sendler M, Hegyi E, Beyer G, Lerch MM, Sahin-Tóth M. Mayerle J, et al. Gastroenterology. 2019 May;156(7):1951-1968.e1. doi: 10.1053/j.gastro.2018.11.081. Epub 2019 Jan 18. Gastroenterology. 2019. PMID: 30660731 Free PMC article. Review.
Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis, pancreatic genetics has made rapid progress. The identification of mutations in genes involved in the digestive protease-antiprotease pathway has lent additional support …
Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis, pancreatic genetics has made r …
Diagnosis and Management of Chronic Pancreatitis: A Review.
Singh VK, Yadav D, Garg PK. Singh VK, et al. JAMA. 2019 Dec 24;322(24):2422-2434. doi: 10.1001/jama.2019.19411. JAMA. 2019. PMID: 31860051 Review.
IMPORTANCE: Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas with a prevalence of 42 to 73 per 100 000 adults in the United States. OBSERVATIONS: Both genetic and environmental factors are thought to contribute to the pathogenesis of …
IMPORTANCE: Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas with a prevalence of 42 to 73 per 100 0 …
Hereditary pancreatitis in childhood: course of disease and complications.
Prommer R, Kienbauer M, Kargl S, Schöfl R. Prommer R, et al. Wien Klin Wochenschr. 2021 Jul;133(13-14):669-673. doi: 10.1007/s00508-021-01869-0. Epub 2021 Apr 28. Wien Klin Wochenschr. 2021. PMID: 33909107
BACKGROUND: Hereditary pancreatitis is rare. Pain therapy for juvenile symptom onset, child development and the risk of pancreatic carcinoma in adulthood must be considered. ...The mean KIDSCREEN-T score of 66.9 confirms a very good quality of life. CONCLUSIO …
BACKGROUND: Hereditary pancreatitis is rare. Pain therapy for juvenile symptom onset, child development and the risk of pancre …
Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis.
Lee B, Adamska JZ, Namkoong H, Bellin MD, Wilhelm J, Szot GL, Louis DM, Davis MM, Pandol SJ, Habtezion A. Lee B, et al. J Clin Invest. 2020 May 1;130(5):2705-2711. doi: 10.1172/JCI134066. J Clin Invest. 2020. PMID: 32053120 Free PMC article.
TCRbeta sequencing revealed a significant increase in TCRbeta repertoire diversity and reduced clonality in both CP groups versus controls. Interestingly, we observed differences in Vbeta-Jbeta gene family usage between hereditary and idiopathic CP and a positive correlati …
TCRbeta sequencing revealed a significant increase in TCRbeta repertoire diversity and reduced clonality in both CP groups versus controls. …
Hereditary Pancreatitis in the United States: Survival and Rates of Pancreatic Cancer.
Shelton CA, Umapathy C, Stello K, Yadav D, Whitcomb DC. Shelton CA, et al. Am J Gastroenterol. 2018 Sep;113(9):1376. doi: 10.1038/s41395-018-0194-5. Epub 2018 Jul 18. Am J Gastroenterol. 2018. PMID: 30018304 Free PMC article.
OBJECTIVES: Hereditary pancreatitis (HP), an autosomal dominant disease typically caused by mutations in PRSS1, has a broad range of clinical characteristics and high cumulative risk of pancreatic cancer. ...Risk of pancreatic cancer was significantly greater than a …
OBJECTIVES: Hereditary pancreatitis (HP), an autosomal dominant disease typically caused by mutations in PRSS1, has a broad ra …
Genetics and Genetic Testing in Pancreatic Cancer.
Whitcomb DC, Shelton CA, Brand RE. Whitcomb DC, et al. Gastroenterology. 2015 Oct;149(5):1252-1264.e4. doi: 10.1053/j.gastro.2015.07.057. Epub 2015 Aug 6. Gastroenterology. 2015. PMID: 26255042 Review.
Over many years, the combination of inflammation, exposure to DNA-damaging toxins, and failed DNA repair promote the accumulation of somatic mutations in pancreatic cells; PDAC risk is further increased by already present oncogenic germline mutations. Predictive models and …
Over many years, the combination of inflammation, exposure to DNA-damaging toxins, and failed DNA repair promote the accumulation of somatic …
Inflammation and Cancer V. Chronic pancreatitis and pancreatic cancer.
Whitcomb DC. Whitcomb DC. Am J Physiol Gastrointest Liver Physiol. 2004 Aug;287(2):G315-9. doi: 10.1152/ajpgi.00115.2004. Am J Physiol Gastrointest Liver Physiol. 2004. PMID: 15246966 Free article. Review.
Pancreatic inflammation appears to increase the risk of pancreatic cancer. This observation is striking in the hereditary pancreatitis kindreds but also occurs in alcoholic, idiopathic, and tropical chronic pancreatitis and cystic fibrosis. However, the mutat …
Pancreatic inflammation appears to increase the risk of pancreatic cancer. This observation is striking in the hereditary p …
Environmental risk factors for chronic pancreatitis and pancreatic cancer.
Nitsche C, Simon P, Weiss FU, Fluhr G, Weber E, Gärtner S, Behn CO, Kraft M, Ringel J, Aghdassi A, Mayerle J, Lerch MM. Nitsche C, et al. Dig Dis. 2011;29(2):235-42. doi: 10.1159/000323933. Epub 2011 Jul 5. Dig Dis. 2011. PMID: 21734390 Review.
Chronic pancreatitis has long been thought to be mainly associated with immoderate alcohol consumption. The observation that only 10% of heavy drinkers develop chronic pancreatitis not only suggests that other environmental factors, such as tobacco smoke, are potent additi …
Chronic pancreatitis has long been thought to be mainly associated with immoderate alcohol consumption. The observation that only 10% …
Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection.
Becker AE, Hernandez YG, Frucht H, Lucas AL. Becker AE, et al. World J Gastroenterol. 2014 Aug 28;20(32):11182-98. doi: 10.3748/wjg.v20.i32.11182. World J Gastroenterol. 2014. PMID: 25170203 Free PMC article. Review.
Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; …
Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Synd …
Chronic progression of cerulein-induced acute pancreatitis in trypsinogen mutant mice.
Jancsó Z, Sahin-Tóth M. Jancsó Z, et al. Pancreatology. 2022 Mar;22(2):248-257. doi: 10.1016/j.pan.2022.01.007. Epub 2022 Jan 14. Pancreatology. 2022. PMID: 35063369 Free PMC article.
T7K24R mice carry mutation p.K24R in mouse cationic trypsinogen (isoform T7), which is analogous to the human hereditary pancreatitis-associated mutation p.K23R. The mutation renders trypsinogen more prone to autoactivation. ...The objective of the present study was …
T7K24R mice carry mutation p.K24R in mouse cationic trypsinogen (isoform T7), which is analogous to the human hereditary pancreati …
84 results