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Quoted phrase not found in phrase index: "Hereditary spastic paraplegia 50"
Page 1
Intrathecal AAV9/AP4M1 gene therapy for hereditary spastic paraplegia 50 shows safety and efficacy in preclinical studies.
Chen X, Dong T, Hu Y, De Pace R, Mattera R, Eberhardt K, Ziegler M, Pirovolakis T, Sahin M, Bonifacino JS, Ebrahimi-Fakhari D, Gray SJ. Chen X, et al. J Clin Invest. 2023 May 15;133(10):e164575. doi: 10.1172/JCI164575. J Clin Invest. 2023. PMID: 36951961 Free PMC article.
Spastic paraplegia 50 (SPG50) is an ultrarare childhood-onset neurological disorder caused by biallelic loss-of-function variants in the AP4M1 gene. ...-administered AAV9/AP4M1, supporting an investigational gene transfer clinical trial to treat …
Spastic paraplegia 50 (SPG50) is an ultrarare childhood-onset neurological disorder caused by biallelic loss-of-functio …
A Randomized Controlled Trial of the Effect of Repetitive Transcranial Magnetic Stimulation of the Motor Cortex on Lower Extremity Spasticity in Hereditary Spastic Paraplegia.
Bastani PB, Kordjazi M, Oveisgharan S, Abdi S. Bastani PB, et al. J Clin Neurophysiol. 2023 Feb 1;40(2):173-179. doi: 10.1097/WNP.0000000000000874. Epub 2021 Nov 23. J Clin Neurophysiol. 2023. PMID: 34817445 Clinical Trial.
INTRODUCTION: Hereditary spastic paraplegia refers to a group of conditions characterized by a slow progression of spasticity in lower limbs resulting in gait abnormalities. ...CONCLUSIONS: Repetitive transcranial magnetic stimulation is an effective method i …
INTRODUCTION: Hereditary spastic paraplegia refers to a group of conditions characterized by a slow progression of spas …
Factors influencing disease progression in autosomal dominant cerebellar ataxia and spastic paraplegia.
Tezenas du Montcel S, Charles P, Goizet C, Marelli C, Ribai P, Vincitorio C, Anheim M, Guyant-Maréchal L, Le Bayon A, Vandenberghe N, Tchikviladzé M, Devos D, Le Ber I, N'Guyen K, Cazeneuve C, Tallaksen C, Brice A, Durr A. Tezenas du Montcel S, et al. Arch Neurol. 2012 Apr;69(4):500-8. doi: 10.1001/archneurol.2011.2713. Arch Neurol. 2012. PMID: 22491195
PATIENTS: One hundred sixty-two patients with autosomal dominant cerebellar ataxia and 64 with hereditary spastic paraplegia. MAIN OUTCOME MEASURES: The quantitative Composite Cerebellar Functional Severity Score with the writing test (CCFSw) and Scale for th …
PATIENTS: One hundred sixty-two patients with autosomal dominant cerebellar ataxia and 64 with hereditary spastic paraplegi …
Visual inspection methods for cervical cancer prevention.
Sankaranarayanan R, Nessa A, Esmy PO, Dangou JM. Sankaranarayanan R, et al. Best Pract Res Clin Obstet Gynaecol. 2012 Apr;26(2):221-32. doi: 10.1016/j.bpobgyn.2011.08.003. Epub 2011 Nov 9. Best Pract Res Clin Obstet Gynaecol. 2012. PMID: 22075441 Review.
Realistic sensitivity of a quality- assured single visual inspection with acetic acid is around 50%. A single round of visual inspection with acetic acid screening has been associated with a 25-35% reduction in cervical cancer incidence and the frequency of cervical intrae …
Realistic sensitivity of a quality- assured single visual inspection with acetic acid is around 50%. A single round of visual inspect …
Voiding dysfunction in patients with spastic paraplegia: urodynamic evaluation and response to continuous intrathecal baclofen.
Bushman W, Steers WD, Meythaler JM. Bushman W, et al. Neurourol Urodyn. 1993;12(2):163-70. doi: 10.1002/nau.1930120210. Neurourol Urodyn. 1993. PMID: 7920673
Patients with hereditary spastic paraplegia (HSP), a degenerative central nervous system disorder characterized by progressive lower extremity spasticity, frequently experience symptoms of voiding dysfunction. ...In addition, one patient exhibited markedly di …
Patients with hereditary spastic paraplegia (HSP), a degenerative central nervous system disorder characterized by prog …
The relationship between anaerobic lactate threshold and plasma catecholamines during incremental exercise in hereditary spastic paraplegia.
Siciliano G, Pasquali L, Manca ML, Del Corona A, Tessa A, Patrono C, Prontera C, Zucchelli G, Santorelli FM. Siciliano G, et al. Funct Neurol. 2003 Apr-Jun;18(2):83-7. Funct Neurol. 2003. PMID: 12911138 Clinical Trial.
Lower limb muscle chronic hyperactivity in hereditary spastic paraplegia (HSP) is the consequence of motor corticospinal tract involvement, which in turn has been hypothesized to be of mitochondrial origin. ...In the patients, the anaerobic lactate threshold …
Lower limb muscle chronic hyperactivity in hereditary spastic paraplegia (HSP) is the consequence of motor corticospina …
The clinical effect of the GABA-agonist, progabide, on spasticity.
Mondrup K, Pedersen E. Mondrup K, et al. Acta Neurol Scand. 1984 Apr;69(4):200-6. doi: 10.1111/j.1600-0404.1984.tb07802.x. Acta Neurol Scand. 1984. PMID: 6377802 Clinical Trial.
In a double-blind cross-over trial of two 2-week periods, the clinical effect of progabide was compared to placebo. 16 patients with spasticity in a stationary phase completed the trial. 14 had multiple sclerosis, 2 hereditary spastic paraple …
In a double-blind cross-over trial of two 2-week periods, the clinical effect of progabide was compared to placebo. 16 patient …