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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 2
2001 2
2002 5
2003 2
2004 5
2005 4
2006 7
2007 7
2008 4
2009 4
2010 3
2011 2
2012 1
2015 4
2016 2
2017 3
2019 1
2020 1
2021 2
2023 1
2024 0

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60 results

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Page 1
Expending Role of Microsatellite Instability in Diagnosis and Treatment of Colorectal Cancers.
Chang L, Chang M, Chang HM, Chang F. Chang L, et al. J Gastrointest Cancer. 2017 Dec;48(4):305-313. doi: 10.1007/s12029-017-9991-0. J Gastrointest Cancer. 2017. PMID: 28699072 Free PMC article. Review.
Based on the recent research data, we provide an update on the MSI testing, along with the evolving role of MSI in diagnosis, prognosis and treatment of colorectal cancers. RESULTS: Studies have led to significant advances in the molecular pathogenesis and clinicopathologi …
Based on the recent research data, we provide an update on the MSI testing, along with the evolving role of MSI in diagnosis, prognosis …
Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.
Imai K, Yamamoto H. Imai K, et al. Carcinogenesis. 2008 Apr;29(4):673-80. doi: 10.1093/carcin/bgm228. Epub 2007 Oct 17. Carcinogenesis. 2008. PMID: 17942460 Review.
Therefore, the diagnosis of MSI-H in cancers is thus considered to be of increasing relevance, because MSI-H is a useful screening marker for identifying patients with Lynch syndrome, a better prognostic factor and could affect the efficacy of chemotherapy. This review add …
Therefore, the diagnosis of MSI-H in cancers is thus considered to be of increasing relevance, because MSI-H is a useful screening marker fo …
Effects of microsatellite instability on recurrence patterns and outcomes in colorectal cancers.
Kim CG, Ahn JB, Jung M, Beom SH, Kim C, Kim JH, Heo SJ, Park HS, Kim JH, Kim NK, Min BS, Kim H, Koom WS, Shin SJ. Kim CG, et al. Br J Cancer. 2016 Jun 28;115(1):25-33. doi: 10.1038/bjc.2016.161. Epub 2016 May 26. Br J Cancer. 2016. PMID: 27228287 Free PMC article.
However, it is unclear whether MSI affects the prognosis of recurrent CRCs. METHODS: This study included 2940 patients with stage I-III CRC who underwent complete resection. ...CONCLUSIONS: Recurrence patterns differed between MSI-H CRC and MSI-L/MSS CRC, and recurrent MSI …
However, it is unclear whether MSI affects the prognosis of recurrent CRCs. METHODS: This study included 2940 patients with stage I-I …
Predictive model for high-frequency microsatellite instability in colorectal cancer patients over 50 years of age.
Fujiyoshi K, Yamaguchi T, Kakuta M, Takahashi A, Arai Y, Yamada M, Yamamoto G, Ohde S, Takao M, Horiguchi SI, Natsume S, Kazama S, Nishizawa Y, Nishimura Y, Akagi Y, Sakamoto H, Akagi K. Fujiyoshi K, et al. Cancer Med. 2017 Jun;6(6):1255-1263. doi: 10.1002/cam4.1088. Epub 2017 May 23. Cancer Med. 2017. PMID: 28544821 Free PMC article.
We analyzed a test cohort of CRC patients aged 50 years (n = 2219) by multivariate logistic regression analyses to identify predictors of high-frequency MSI (MSI-H). The created prediction model was validated in an external cohort (n = 992). ...The area under curve …
We analyzed a test cohort of CRC patients aged 50 years (n = 2219) by multivariate logistic regression analyses to identify predictors …
Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens.
Ishino T, Kawashima S, Tanji E, Ueno T, Ueda Y, Ogasawara S, Sato K, Mano H, Ishihara S, Kato N, Kawazu M, Togashi Y. Ishino T, et al. Br J Cancer. 2023 Apr;128(6):1166-1175. doi: 10.1038/s41416-023-02165-6. Epub 2023 Feb 2. Br J Cancer. 2023. PMID: 36732592 Free PMC article.
BACKGROUND: Identifying biomarkers to predict immune checkpoint inhibitor (ICI) efficacy is warranted. Considering that somatic mutation-derived neoantigens induce strong immune responses, patients with a high tumour mutational burden reportedly tend to respond to ICIs. .. …
BACKGROUND: Identifying biomarkers to predict immune checkpoint inhibitor (ICI) efficacy is warranted. Considering that somatic mutat …
Automated, multiplex assay for high-frequency microsatellite instability in colorectal cancer.
Nash GM, Gimbel M, Shia J, Culliford AT, Nathanson DR, Ndubuisi M, Yamaguchi Y, Zeng ZS, Barany F, Paty PB. Nash GM, et al. J Clin Oncol. 2003 Aug 15;21(16):3105-12. doi: 10.1200/JCO.2003.11.133. J Clin Oncol. 2003. PMID: 12915601
This assay identifies a smaller MSI-H cohort with more homogeneous clinical features and is superior as a marker of favorable prognosis. It merits prospective evaluation as a marker of prognosis and as a screening test for HNPCC....
This assay identifies a smaller MSI-H cohort with more homogeneous clinical features and is superior as a marker of favorable prognosis …
Determination of therapeutic agents efficiencies of microsatellite instability high colon cancer cells in post-metastatic liver biochip modeling.
Bayir Garbioglu D, Demir N, Ozel C, Avci H, Dincer M. Bayir Garbioglu D, et al. FASEB J. 2021 Sep;35(9):e21834. doi: 10.1096/fj.202100333R. FASEB J. 2021. PMID: 34403553
Biological properties of CMS1 (MSI-H type) can affect therapeutic efficiencies of agents used in the treatment of CRC, and therefore become a new predictive factor of the treatment. But, the predictive impact of MSI-H status for adjuvant chemotherapy remains controv …
Biological properties of CMS1 (MSI-H type) can affect therapeutic efficiencies of agents used in the treatment of CRC, and therefore become …
Low-frequency microsatellite instability in genomic di-nucleotide sequences correlates with lymphatic invasion and poor prognosis in gastric cancer.
Zhao Y, Zheng ZC, Luo YH, Piao HZ, Zheng GL, Shi JY, Zhang T, Zhang JJ. Zhao Y, et al. Cell Biochem Biophys. 2015 Jan;71(1):235-41. doi: 10.1007/s12013-014-0189-9. Cell Biochem Biophys. 2015. PMID: 25108737
MSI-L was correlated with more advanced tumor Node Metastasis stage, and more frequent lymph node metastasis. The unfavorable prognosis predicted by MSI-L was ascribed to its correlation with lymphatic invasion. MSI-L characterized by di-nucleotide markers represent …
MSI-L was correlated with more advanced tumor Node Metastasis stage, and more frequent lymph node metastasis. The unfavorable prognosis …
Chemosensitivity and survival in gastric cancer patients with microsatellite instability.
Oki E, Kakeji Y, Zhao Y, Yoshida R, Ando K, Masuda T, Ohgaki K, Morita M, Maehara Y. Oki E, et al. Ann Surg Oncol. 2009 Sep;16(9):2510-5. doi: 10.1245/s10434-009-0580-8. Epub 2009 Jun 30. Ann Surg Oncol. 2009. PMID: 19565284
INTRODUCTION: Conflicting data exist regarding the relevance of high-frequency microsatellite instability (MSI-H) for predicting the prognosis and benefits of 5-fluorouracil (5-FU)-based chemotherapy. This study investigated the usefulness of MSI as either a prog …
INTRODUCTION: Conflicting data exist regarding the relevance of high-frequency microsatellite instability (MSI-H) for predicting the …
60 results