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1984 1
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Page 1
Patterns of BrdU incorporation in homogeneously staining regions and double minutes.
Krawczun MS, Camargo M, Cervenka J. Krawczun MS, et al. Cancer Genet Cytogenet. 1986 Apr 1;21(3):257-65. doi: 10.1016/0165-4608(86)90006-3. Cancer Genet Cytogenet. 1986. PMID: 2418948
The replication chronology of two structural chromosome abnormalities linked to the amplification phenomenon of DNA sequences was investigated. Three cell lines containing homogeneously staining region (HSR) chromosomes (IMR-32, MK42, and COLO-320) and one li …
The replication chronology of two structural chromosome abnormalities linked to the amplification phenomenon of DNA sequences was investigat …
Jumping translocation of homogeneously staining region and tetraploidy with double minutes in acute myelomonocytic leukemia.
Yoshida T, Kimura N, Akiyoshi T, Ohshima K, Nagano M, Morioka E, Hisano S, Ohyashiki K, Kamada N, Tamura K. Yoshida T, et al. Cancer Genet Cytogenet. 1999 Feb;109(1):40-4. doi: 10.1016/s0165-4608(98)00144-7. Cancer Genet Cytogenet. 1999. PMID: 9973958
We report a 71-year-old patient with acute myelomonocytic leukemia (AMMoL) who had complicated chromosomal abnormalities showing diploidy with a jumping translocation of a homogeneously staining region (hsr) and tetraploidy with double minutes (dmin). ...
We report a 71-year-old patient with acute myelomonocytic leukemia (AMMoL) who had complicated chromosomal abnormalities showing diploidy wi …
Twenty-four-color spectral karyotyping reveals chromosome aberrations in cytogenetically normal acute myeloid leukemia.
Zhang FF, Murata-Collins JL, Gaytan P, Forman SJ, Kopecky KJ, Willman CL, Appelbaum FR, Slovak ML. Zhang FF, et al. Genes Chromosomes Cancer. 2000 Jul;28(3):318-28. doi: 10.1002/1098-2264(200007)28:3<318::aid-gcc10>3.0.co;2-m. Genes Chromosomes Cancer. 2000. PMID: 10862038
The test population was comprised of 28 cryopreserved, cytogenetically normal acute myeloid leukemia (AML) samples from patients registered to a randomized trial for previously untreated AML (SWOG 9031). Two normal and 12 samples with known cytogenetic aberrations w …
The test population was comprised of 28 cryopreserved, cytogenetically normal acute myeloid leukemia (AML) samples from patients registered …
Sequential emergence of MRP- and MDR1-gene over-expression as well as MDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines.
Zhou DC, Ramond S, Viguie F, Faussat AM, Zittoun R, Marie JP. Zhou DC, et al. Int J Cancer. 1996 Jan 26;65(3):365-71. doi: 10.1002/(SICI)1097-0215(19960126)65:3<365::AID-IJC15>3.0.CO;2-9. Int J Cancer. 1996. PMID: 8575859 Free article.
Southern-blot analysis revealed no MRP-gene amplification in any of the 5 sub-lines, whereas the MDR1 gene was amplified in the high-level-resistant K-H300 and K-H400 sub-lines. The most interesting observation is a homogeneously staining region (HSR) found i …
Southern-blot analysis revealed no MRP-gene amplification in any of the 5 sub-lines, whereas the MDR1 gene was amplified in the high-level-r …
The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification.
Slovak ML, Ho JP, Cole SP, Deeley RG, Greenberger L, de Vries EG, Broxterman HJ, Scheffer GL, Scheper RJ. Slovak ML, et al. Cancer Res. 1995 Oct 1;55(19):4214-9. Cancer Res. 1995. PMID: 7671223
Two color hybridization studies indicated that HT1080/DR4 fibrosarcoma cells contain amplification of both the MRP and LRP genes in a striking striped pattern in the homogeneously staining region, hsr(7)(p12p15). In contrast, only amplified MRP gene sequences …
Two color hybridization studies indicated that HT1080/DR4 fibrosarcoma cells contain amplification of both the MRP and LRP genes in a striki …
Protein overexpression and gene amplification of c-erb B-2 in pulmonary carcinomas: a comparative immunohistochemical and fluorescence in situ hybridization study.
Hirashima N, Takahashi W, Yoshii S, Yamane T, Ooi A. Hirashima N, et al. Mod Pathol. 2001 Jun;14(6):556-62. doi: 10.1038/modpathol.3880350. Mod Pathol. 2001. PMID: 11406656
Among the 23 tumors, three tumors showed low-level amplification (less than 3-fold), which was differentiated from polysomy 17 found in the other two. In the 30 non-small cell lung carcinomas selected at random from 151 with negative immunostaining, there were five trisomy …
Among the 23 tumors, three tumors showed low-level amplification (less than 3-fold), which was differentiated from polysomy 17 found in the …
Effects of cyclophosphamide, cis-platinum, nitrosourea (ACNU), melphalan, and dacarbazine on a cytogenetically highly malignant neuroblastoma xenograft.
Makino S, Tsuchida Y, Nakajo T, Kanda N, Kaneko Y. Makino S, et al. Med Pediatr Oncol. 1986;14(1):36-40. doi: 10.1002/mpo.2950140109. Med Pediatr Oncol. 1986. PMID: 2419742
Cytogenetically and molecular-cytogenetically, this xenograft is known to have a homogeneously staining region (HSR) on chromosome 20 and to exhibit 60- to 80-fold amplification of clone #8 (1.75 kb) and N-myc (2.1 kb) in the HSR. ...
Cytogenetically and molecular-cytogenetically, this xenograft is known to have a homogeneously staining region (HSR) on …
Effects of newly introduced chemotherapeutic agents on a cytogenetically highly malignant neuroblastoma, xenotransplanted in nude mice.
Makino S, Kashii A, Kanazawa K, Tsuchida Y. Makino S, et al. J Pediatr Surg. 1993 Apr;28(4):612-6. doi: 10.1016/0022-3468(93)90671-7. J Pediatr Surg. 1993. PMID: 8483078
A human neuroblastoma xenograft, designated TNB9, was used in this experiment. This xenograft is known to have a homogeneously staining region (HSR) on chromosome 20 and to exhibit 60- to 100-fold amplification of clones 8, G21 and N-myc, and showed a rapid t …
A human neuroblastoma xenograft, designated TNB9, was used in this experiment. This xenograft is known to have a homogeneously sta …
Cytogenetic analysis of retinoblastoma: evidence for multifocal origin and in vivo gene amplification.
Chaum E, Ellsworth RM, Abramson DH, Haik BG, Kitchin FD, Chaganti RS. Chaum E, et al. Cytogenet Cell Genet. 1984;38(2):82-91. doi: 10.1159/000132037. Cytogenet Cell Genet. 1984. PMID: 6467991
In general, the tumors were chromosomally stable, although karyotypic evolution and random chromosome loss were encountered. Consistent abnormalities included trisomy 1q, i(6p), 6q-, and del(13)(q12----14). ...These two patients provide some of the first cytogenetic eviden …
In general, the tumors were chromosomally stable, although karyotypic evolution and random chromosome loss were encountered. Consiste …
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