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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1988 1
1989 2
1990 2
1991 1
1992 1
1994 2
1995 2
1996 1
1998 4
1999 4
2000 5
2001 4
2002 5
2003 2
2004 7
2005 2
2006 2
2007 3
2008 7
2009 6
2010 5
2011 3
2012 5
2013 5
2014 1
2015 1
2016 4
2017 8
2018 7
2019 6
2020 3
2021 5
2022 2
2023 2
2024 0

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111 results

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Page 1
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.
Kinneer K, Wortmann P, Cooper ZA, Dickinson NJ, Masterson L, Cailleau T, Hutchinson I, Vijayakrishnan B, McFarlane M, Ball K, Davies M, Lewis A, Huang Y, Rosenbaum AI, Yuan J, Chesebrough J, Anderton J, Monks N, Novick S, Wang J, Dimasi N, Christie RJ, Sabol D, Tosto FA, Wallez Y, Leo E, Albertella MR, Staniszewska AD, Tice DA, Howard PW, Luheshi N, Sapra P. Kinneer K, et al. Among authors: howard pw. Clin Cancer Res. 2023 Mar 14;29(6):1086-1101. doi: 10.1158/1078-0432.CCR-22-2630. Clin Cancer Res. 2023. PMID: 36355054
ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies.
Zammarchi F, Corbett S, Adams L, Tyrer PC, Kiakos K, Janghra N, Marafioti T, Britten CE, Havenith CEG, Chivers S, D'Hooge F, Williams DG, Tiberghien A, Howard PW, Hartley JA, van Berkel PH. Zammarchi F, et al. Among authors: howard pw. Blood. 2018 Mar 8;131(10):1094-1105. doi: 10.1182/blood-2017-10-813493. Epub 2018 Jan 3. Blood. 2018. PMID: 29298756 Free article.
Antibody-drug conjugates - a perfect synergy.
Adair JR, Howard PW, Hartley JA, Williams DG, Chester KA. Adair JR, et al. Among authors: howard pw. Expert Opin Biol Ther. 2012 Sep;12(9):1191-206. doi: 10.1517/14712598.2012.693473. Epub 2012 Jun 1. Expert Opin Biol Ther. 2012. PMID: 22650648 Review.
Potentiation of PBD Dimers by Lipophilicity Manipulation.
Cailleau T, Adams LR, Arora N, Kang GD, Masterson L, Patel N, Hartley JA, Mao S, Harper J, Howard PW. Cailleau T, et al. Among authors: howard pw. Curr Top Med Chem. 2019;19(9):741-752. doi: 10.2174/1568026619666190401112517. Curr Top Med Chem. 2019. PMID: 30931859
Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody-Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer.
Gregson SJ, Pugh K, Patel N, Afif-Rider S, Vijayakrishnan B, Santos K, Riedl J, Hutchinson I, Kang GD, Chooi KP, Beard R, Adams L, Barry CS, Ball K, Masterson LA, McFarlane M, Hartley JA, Howard PW. Gregson SJ, et al. Among authors: howard pw. Mol Cancer Ther. 2022 Sep 6;21(9):1439-1448. doi: 10.1158/1535-7163.MCT-22-0145. Mol Cancer Ther. 2022. PMID: 35793464
Building a Simple and Versatile Illumination System for Optogenetic Experiments.
Kyriakakis P, Fernandez de Cossio L, Howard PW, Kouv S, Catanho M, Hu VJ, Kyriakakis R, Allen ME, Ma Y, Aguilar-Rivera M, Coleman TP. Kyriakakis P, et al. Among authors: howard pw. J Vis Exp. 2021 Jan 12;(167):10.3791/61914. doi: 10.3791/61914. J Vis Exp. 2021. PMID: 33522514 Free PMC article.
Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation.
Christie RJ, Tiberghien AC, Du Q, Bezabeh B, Fleming R, Shannon A, Mao S, Breen S, Zhang J, Zhong H, Harper J, Wu H, Howard PW, Gao C. Christie RJ, et al. Among authors: howard pw. Antibodies (Basel). 2017 Nov 28;6(4):20. doi: 10.3390/antib6040020. Antibodies (Basel). 2017. PMID: 31548535 Free PMC article.
Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity.
Tiberghien AC, Vijayakrishnan B, Esfandiari A, Ahmed M, Pardo R, Bingham J, Adams L, Santos K, Kang GD, Pugh KM, Afif-Rider S, Vashisht K, Haque K, Tammali R, Rosfjord E, Savoca A, Hartley JA, Howard PW. Tiberghien AC, et al. Among authors: howard pw. Mol Cancer Ther. 2023 Feb 1;22(2):254-263. doi: 10.1158/1535-7163.MCT-21-0693. Mol Cancer Ther. 2023. PMID: 36722141
111 results