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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1977 1
1978 2
1979 1
1981 2
1983 3
1984 2
1985 2
1986 2
1987 2
1988 3
1989 2
1990 3
1991 5
1992 5
1993 4
1994 4
1995 1
1996 2
1997 4
1998 4
1999 5
2000 6
2001 5
2002 3
2003 9
2004 4
2005 3
2006 4
2007 6
2008 3
2009 4
2010 7
2011 6
2012 10
2013 3
2014 8
2015 10
2016 4
2017 9
2018 8
2019 10
2020 10
2021 12
2022 10
2023 12
2024 7

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213 results

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Page 1
Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.
Castro M, Corren J, Pavord ID, Maspero J, Wenzel S, Rabe KF, Busse WW, Ford L, Sher L, FitzGerald JM, Katelaris C, Tohda Y, Zhang B, Staudinger H, Pirozzi G, Amin N, Ruddy M, Akinlade B, Khan A, Chao J, Martincova R, Graham NMH, Hamilton JD, Swanson BN, Stahl N, Yancopoulos GD, Teper A. Castro M, et al. N Engl J Med. 2018 Jun 28;378(26):2486-2496. doi: 10.1056/NEJMoa1804092. Epub 2018 May 21. N Engl J Med. 2018. PMID: 29782217 Free article. Clinical Trial.
Among patients with a blood eosinophil count of 300 or more per cubic millimeter, the annualized rate of severe asthma exacerbations was 0.37 (95% CI, 0.29 to 0.48) among those receiving lower-dose dupilumab and 1.08 (95% CI, 0.85 to 1.38) among those receiving a matched placebo …
Among patients with a blood eosinophil count of 300 or more per cubic millimeter, the annualized rate of severe asthma exacerbations was 0.3 …
The DRESS syndrome: a literature review.
Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, Roujeau JC. Cacoub P, et al. Am J Med. 2011 Jul;124(7):588-97. doi: 10.1016/j.amjmed.2011.01.017. Epub 2011 May 17. Am J Med. 2011. PMID: 21592453 Review.
Diagnosing DRESS is challenging due to the diversity of cutaneous eruption and organs involved. We used the RegiSCAR scoring system that grades DRESS cases as "no," "possible," "probable," or "definite" to classify cases reported in the literature. ...Culprit drug w …
Diagnosing DRESS is challenging due to the diversity of cutaneous eruption and organs involved. We used the RegiSCAR scoring syste …
Dupilumab-Associated Adverse Events During Treatment of Allergic Diseases.
Kychygina A, Cassagne M, Tauber M, Galiacy S, Paul C, Fournié P, Simon M. Kychygina A, et al. Clin Rev Allergy Immunol. 2022 Jun;62(3):519-533. doi: 10.1007/s12016-022-08934-0. Epub 2022 Mar 11. Clin Rev Allergy Immunol. 2022. PMID: 35275334 Review.
., dry eyes, conjunctivitis, blepharitis, keratitis, and ocular pruritus), head and neck dermatitis, onset of psoriatic lesions, progression of cutaneous T-cell lymphoma exacerbation, alopecia areata, hypereosinophilia, and arthritis. Most are managed during dupilumab trea …
., dry eyes, conjunctivitis, blepharitis, keratitis, and ocular pruritus), head and neck dermatitis, onset of psoriatic lesions, progression …
Eosinophilia Induced by Blocking the IL-4/IL-13 Pathway: Potential Mechanisms and Clinical Outcomes.
Olaguibel JM, Sastre J, Rodríguez JM, Del Pozo V. Olaguibel JM, et al. J Investig Allergol Clin Immunol. 2022 Jun 20;32(3):165-180. doi: 10.18176/jiaci.0823. Epub 2022 May 6. J Investig Allergol Clin Immunol. 2022. PMID: 35522053 Free article. Review.
They all block type 2 inflammatory pathways by targeting IgE (omalizumab), the IL-5 pathway (mepolizumab, reslizumab, benralizumab), or the IL-4/IL-13 pathway (dupilumab). Hypereosinophilia has been observed in 4%-25% of patients treated with dupilumab and is transi …
They all block type 2 inflammatory pathways by targeting IgE (omalizumab), the IL-5 pathway (mepolizumab, reslizumab, benralizumab), or the …
Unmet needs and evidence gaps in hypereosinophilic syndrome and eosinophilic granulomatosis with polyangiitis.
Wechsler ME, Hellmich B, Cid MC, Jayne D, Tian X, Baylis L, Roufosse F. Wechsler ME, et al. J Allergy Clin Immunol. 2023 Jun;151(6):1415-1428. doi: 10.1016/j.jaci.2023.03.011. Epub 2023 Apr 21. J Allergy Clin Immunol. 2023. PMID: 37086239 Free article. Review.
For example, in most cases of HES, the underlying cause of hypereosinophilia is unknown, while in EGPA, although a polygenic genetic susceptibility has been found, understanding of the pathogenic mechanisms remains largely elusive. ...Furthermore, disease-specific activity …
For example, in most cases of HES, the underlying cause of hypereosinophilia is unknown, while in EGPA, although a polygenic genetic …
STAT6 gain-of-function variant exacerbates multiple allergic symptoms.
Takeuchi I, Yanagi K, Takada S, Uchiyama T, Igarashi A, Motomura K, Hayashi Y, Nagano N, Matsuoka R, Sugiyama H, Yoshioka T, Saito H, Kawai T, Miyaji Y, Inuzuka Y, Matsubara Y, Ohya Y, Shimizu T, Matsumoto K, Arai K, Nomura I, Kaname T, Morita H. Takeuchi I, et al. J Allergy Clin Immunol. 2023 May;151(5):1402-1409.e6. doi: 10.1016/j.jaci.2022.12.802. Epub 2022 Dec 17. J Allergy Clin Immunol. 2023. PMID: 36538978
OBJECTIVES: We sought to clarify the molecular pathogenesis of a patient with early-onset multiple allergic diseases, a high serum IgE level, hypereosinophilia, treatment-resistant severe atopic dermatitis with increased dermal collagen fiber deposition, and eosinophilic g …
OBJECTIVES: We sought to clarify the molecular pathogenesis of a patient with early-onset multiple allergic diseases, a high serum IgE level …
Eosinophilic arthritis.
Tay C. Tay C. Rheumatology (Oxford). 1999 Dec;38(12):1188-94. doi: 10.1093/rheumatology/38.12.1188. Rheumatology (Oxford). 1999. PMID: 10587544
Treatment with oral NSAIDs did not relieve the joint symptoms nor reduce the hypereosinophilia, but oral prednisolone brought rapid recovery to five out of eight patients. ...Complete resolution of arthritis and normalization of eosinophil count were observed after …
Treatment with oral NSAIDs did not relieve the joint symptoms nor reduce the hypereosinophilia, but oral prednisolone brought rapid r …
Churg-Strauss syndrome.
Pagnoux C, Guilpain P, Guillevin L. Pagnoux C, et al. Curr Opin Rheumatol. 2007 Jan;19(1):25-32. doi: 10.1097/BOR.0b013e3280119854. Curr Opin Rheumatol. 2007. PMID: 17143092 Review.
PURPOSE OF REVIEW: Churg-Strauss syndrome is a small-vessel necrotizing vasculitis typically characterized by asthma, lung infiltrates, extravascular necrotizing granulomas and hypereosinophilia. The most recent clinical studies on its pathogenesis and therapeutic manageme …
PURPOSE OF REVIEW: Churg-Strauss syndrome is a small-vessel necrotizing vasculitis typically characterized by asthma, lung infiltrates, extr …
Hypereosinophilic syndromes.
Roufosse FE, Goldman M, Cogan E. Roufosse FE, et al. Orphanet J Rare Dis. 2007 Sep 11;2:37. doi: 10.1186/1750-1172-2-37. Orphanet J Rare Dis. 2007. PMID: 17848188 Free PMC article. Review.
Target-organ damage mediated by eosinophils is highly variable among patients, with involvement of skin, heart, lungs, and central and peripheral nervous systems in more than 50% of cases. Other frequently observed complications include hepato- and/or splenomegaly, eosinop …
Target-organ damage mediated by eosinophils is highly variable among patients, with involvement of skin, heart, lungs, and central and perip …
Therapeutic strategies for eosinophilic dermatoses.
Simon D, Simon HU. Simon D, et al. Curr Opin Pharmacol. 2019 Jun;46:29-33. doi: 10.1016/j.coph.2019.01.002. Epub 2019 Feb 10. Curr Opin Pharmacol. 2019. PMID: 30743138 Review.
Eosinophil infiltration is observed in a broad spectrum of skin diseases of various origins. Eosinophils are thought to actively contribute to pathogenesis as they are able to defend against microbes, to regulate inflammation, cause tissue damage, promote remodeling and fi …
Eosinophil infiltration is observed in a broad spectrum of skin diseases of various origins. Eosinophils are thought to actively cont …
213 results