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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 3
1991 3
1992 12
1993 12
1994 13
1995 17
1996 29
1997 59
1998 101
1999 160
2000 205
2001 234
2002 221
2003 240
2004 235
2005 261
2006 258
2007 227
2008 182
2009 172
2010 173
2011 135
2012 146
2013 148
2014 149
2015 124
2016 133
2017 127
2018 138
2019 140
2020 148
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2022 109
2023 100
2024 24

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4,152 results

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Page 1
Hyperhomocysteinemia and cardiovascular diseases.
Guieu R, Ruf J, Mottola G. Guieu R, et al. Ann Biol Clin (Paris). 2022 Feb 1;80(1):7-14. doi: 10.1684/abc.2021.1694. Ann Biol Clin (Paris). 2022. PMID: 35129442 Review.
Hcy is present in plasma, with normal levels between 5 and 15 mumol/L, a slightly elevated level between 15 to 30 mumol/L, moderate from 30 to 100 mumol/L and a value > 100 mumol/L classified as severe hyperhomocysteinemia (HHcy). HHcy has been associated with inflammat …
Hcy is present in plasma, with normal levels between 5 and 15 mumol/L, a slightly elevated level between 15 to 30 mumol/L, moderate from 30 …
Causes of hyperhomocysteinemia and its pathological significance.
Kim J, Kim H, Roh H, Kwon Y. Kim J, et al. Arch Pharm Res. 2018 Apr;41(4):372-383. doi: 10.1007/s12272-018-1016-4. Epub 2018 Mar 19. Arch Pharm Res. 2018. PMID: 29552692 Review.
Homocysteine is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia is a state in which too much homocysteine is present in the body. The main cause of …
Homocysteine is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylati …
Homocysteine metabolism.
Selhub J. Selhub J. Annu Rev Nutr. 1999;19:217-46. doi: 10.1146/annurev.nutr.19.1.217. Annu Rev Nutr. 1999. PMID: 10448523 Review.
Mild hyperhomocysteinemia seen in fasting conditions is due to mild impairment in the methylation pathway (i.e. folate or B12 deficiencies or methylenetetrahydrofolate reductase thermolability). Post-methionine-load hyperhomocysteinemia may be due to heterozygous cy …
Mild hyperhomocysteinemia seen in fasting conditions is due to mild impairment in the methylation pathway (i.e. folate or B12 deficie …
Homocysteine Modification in Protein Structure/Function and Human Disease.
Jakubowski H. Jakubowski H. Physiol Rev. 2019 Jan 1;99(1):555-604. doi: 10.1152/physrev.00003.2018. Physiol Rev. 2019. PMID: 30427275 Free article. Review.
Epidemiological studies established that elevated homocysteine, an important intermediate in folate, vitamin B(12), and one carbon metabolism, is associated with poor health, including heart and brain diseases. Earlier studies show that patients with severe hyperhomocysteinemi …
Epidemiological studies established that elevated homocysteine, an important intermediate in folate, vitamin B(12), and one carbon metabolis …
Hyperhomocysteinemia in Cardiovascular Diseases: Revisiting Observational Studies and Clinical Trials.
Guéant JL, Guéant-Rodriguez RM, Oussalah A, Zuily S, Rosenberg I. Guéant JL, et al. Thromb Haemost. 2023 Mar;123(3):270-282. doi: 10.1055/a-1952-1946. Epub 2022 Sep 28. Thromb Haemost. 2023. PMID: 36170884 Free article. Review.
In contrast, moderate hyperhomocysteinemia (15-30 mol/L) is a modest predictor of cardiovascular risk. ...Further trials are needed to assess the effect of lowering homocysteine according to hyperhomocysteinemia categories at baseline....
In contrast, moderate hyperhomocysteinemia (15-30 mol/L) is a modest predictor of cardiovascular risk. ...Further trials are needed t …
The link between homocysteine, folic acid and vitamin B12 in chronic kidney disease.
Angelini A, Cappuccilli ML, Magnoni G, Croci Chiocchini AL, Aiello V, Napoletano A, Iacovella F, Troiano A, Mancini R, Capelli I, Cianciolo G. Angelini A, et al. G Ital Nefrol. 2021 Aug 30;38(4):2021-vol4. G Ital Nefrol. 2021. PMID: 34469084 Free article. Review.
Cardiovascular events are the leading causes of death in these patient populations, thus the interest in non-traditional risk factors such as hyperhomocysteinemia, folic acid and vitamin B12 metabolism is growing. Hyperhomocysteinemia is commonly found in CKD patien …
Cardiovascular events are the leading causes of death in these patient populations, thus the interest in non-traditional risk factors such a …
The relationship between hyperhomocysteinemia and neurodegeneration.
Bonetti F, Brombo G, Zuliani G. Bonetti F, et al. Neurodegener Dis Manag. 2016 Apr;6(2):133-45. doi: 10.2217/nmt-2015-0008. Epub 2016 Apr 1. Neurodegener Dis Manag. 2016. PMID: 27033101 Review.
Homocysteine (Hcy) is a key junction in methionine metabolism. In inherited forms of hyperhomocysteinemia patients develop early vascular damage and cognitive decline. Hyperhomocysteinemia is a common consequence of dietary, behavioral and pathological conditions an …
Homocysteine (Hcy) is a key junction in methionine metabolism. In inherited forms of hyperhomocysteinemia patients develop early vasc …
Hyperhomocysteinemia and cardiovascular disease in animal model.
Azad MAK, Huang P, Liu G, Ren W, Teklebrh T, Yan W, Zhou X, Yin Y. Azad MAK, et al. Amino Acids. 2018 Jan;50(1):3-9. doi: 10.1007/s00726-017-2503-5. Epub 2017 Oct 10. Amino Acids. 2018. PMID: 29018979 Review.
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease and is associated with primary causes of mortality and morbidity throughout the world. ...A large number of molecular and biomedical studies in numerous animals, such as mice, rabbits, and pigs, …
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease and is associated with primary causes of mortality and …
Hyperhomocysteinemia and thrombosis.
Lee R, Frenkel EP. Lee R, et al. Hematol Oncol Clin North Am. 2003 Feb;17(1):85-102. doi: 10.1016/s0889-8588(02)00090-4. Hematol Oncol Clin North Am. 2003. PMID: 12627664 Review.
Homocysteine remains an enigmatic marker for vascular disease. Studies have shown hyperhomocysteinemia is a risk factor for VTE, cerebrovascular disease, and coronary artery disease. ...Until there is evidence that treatment improves outcomes, testing for homocysteine and …
Homocysteine remains an enigmatic marker for vascular disease. Studies have shown hyperhomocysteinemia is a risk factor for VTE, cere …
Hyperhomocysteinemia and thrombosis.
Guba SC, Fonseca V, Fink LM. Guba SC, et al. Semin Thromb Hemost. 1999;25(3):291-309. doi: 10.1055/s-2007-994932. Semin Thromb Hemost. 1999. PMID: 10443960 Review.
Both arterial (cerebrovascular, carotid, coronary, and peripheral arterial) and veno-occlusive disease, jointly termed vascular occlusive disease (VOD) in this review, have been associated with hyperhomocysteinemia. In cases of homocystinuria, plasma homocysteine levels ar …
Both arterial (cerebrovascular, carotid, coronary, and peripheral arterial) and veno-occlusive disease, jointly termed vascular occlusive di …
4,152 results