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Page 1
Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development.
Koob GF. Koob GF. Pharmacol Rev. 2021 Jan;73(1):163-201. doi: 10.1124/pharmrev.120.000083. Pharmacol Rev. 2021. PMID: 33318153 Free PMC article. Review.
Hyperkatifeia provides an additional source of motivation for compulsive drug seeking via negative reinforcement. ...Medications and behavioral therapies that reverse hyperkatifeia by resetting brain stress, antistress, and emotional pain systems and returning them …
Hyperkatifeia provides an additional source of motivation for compulsive drug seeking via negative reinforcement. ...Medications and …
Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement.
Koob GF. Koob GF. Biol Psychiatry. 2020 Jan 1;87(1):44-53. doi: 10.1016/j.biopsych.2019.05.023. Epub 2019 Jun 12. Biol Psychiatry. 2020. PMID: 31400808 Review.
However, they also engage the brain systems for stress and pain (somatic and emotional) while producing hyperalgesia and hyperkatifeia, which drive pronounced drug-seeking behavior via processes of negative reinforcement. Hyperkatifeia (derived from the Greek "katif …
However, they also engage the brain systems for stress and pain (somatic and emotional) while producing hyperalgesia and hyperkatifeia …
Anhedonia, Hyperkatifeia, and Negative Reinforcement in Substance Use Disorders.
Koob GF. Koob GF. Curr Top Behav Neurosci. 2022;58:147-165. doi: 10.1007/7854_2021_288. Curr Top Behav Neurosci. 2022. PMID: 35112332 Review.
The present review explores a heuristic framework for understanding the role of anhedonia in addiction, in which anhedonia is a key component of hyperkatifeia (conceptualized as the potentiated intensity of negative emotional/motivational symptoms during drug withdrawal) a …
The present review explores a heuristic framework for understanding the role of anhedonia in addiction, in which anhedonia is a key componen …
Maternal Childhood Maltreatment, Internal Working Models, and Perinatal Substance Use: Is There a Role for Hyperkatifeia? A Systematic Review.
Olsavsky AK, Chirico I, Ali D, Christensen H, Boggs B, Svete L, Ketcham K, Hutchison K, Zeanah C, Tottenham N, Riggs P, Epperson CN. Olsavsky AK, et al. Subst Abuse. 2023 Jul 18;17:11782218231186371. doi: 10.1177/11782218231186371. eCollection 2023. Subst Abuse. 2023. PMID: 37476500 Free PMC article. Review.
Results revealed strong relationships between mothers' childhood maltreatment experiences, less optimal internal working models, and increased risk for perinatal substance use, and importantly, all of these predictors interacted with hyperkatifeia and exerted a marked impa …
Results revealed strong relationships between mothers' childhood maltreatment experiences, less optimal internal working models, and increas …
Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain.
Shurman J, Koob GF, Gutstein HB. Shurman J, et al. Pain Med. 2010 Jul;11(7):1092-8. doi: 10.1111/j.1526-4637.2010.00881.x. Epub 2010 Jun 8. Pain Med. 2010. PMID: 20545871 Free PMC article. Review.
This theoretical article explores the hypothesis that opioid misuse in the context of pain management produces a hypersensitivity to emotional distress, termed hyperkatifeia. RESULTS: In the misuse of opioids, neural substrates that mediate positive emotional states (brain …
This theoretical article explores the hypothesis that opioid misuse in the context of pain management produces a hypersensitivity to emotion …
Corticosteroid sensitization drives opioid addiction.
Carmack SA, Vendruscolo JCM, Adrienne McGinn M, Miranda-Barrientos J, Repunte-Canonigo V, Bosse GD, Mercatelli D, Giorgi FM, Fu Y, Hinrich AJ, Jodelka FM, Ling K, Messing RO, Peterson RT, Rigo F, Edwards S, Sanna PP, Morales M, Hastings ML, Koob GF, Vendruscolo LF. Carmack SA, et al. Mol Psychiatry. 2022 May;27(5):2492-2501. doi: 10.1038/s41380-022-01501-1. Epub 2022 Mar 16. Mol Psychiatry. 2022. PMID: 35296810 Free PMC article.
A driving force for OUD is the dysphoric and emotionally painful state (hyperkatifeia) that is produced during acute and protracted opioid withdrawal. ...
A driving force for OUD is the dysphoric and emotionally painful state (hyperkatifeia) that is produced during acute and protracted o …
Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit/Stress Surfeit Disorder.
Koob GF, Vendruscolo L. Koob GF, et al. Curr Top Behav Neurosci. 2023 Jul 9. doi: 10.1007/7854_2023_424. Online ahead of print. Curr Top Behav Neurosci. 2023. PMID: 37421551
., corticotropin-releasing factor [CRF]) in the extended amygdala, which contributes to hyperkatifeia and greater alcohol intake that is associated with dependence. ...Decreases in the activity of neuropeptide Y, nociception, endocannabinoids, and oxytocin in the extended …
., corticotropin-releasing factor [CRF]) in the extended amygdala, which contributes to hyperkatifeia and greater alcohol intake that …
Alcohol use and the pain system.
Vigorito M, Chang SL. Vigorito M, et al. Adv Drug Alcohol Res. 2024 Jan 24;4:12005. doi: 10.3389/adar.2024.12005. eCollection 2024. Adv Drug Alcohol Res. 2024. PMID: 38389900 Free PMC article. Review.
22 results