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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 2
1978 1
1979 2
1981 1
1982 1
1984 1
1985 2
1990 1
1992 1
1993 1
1994 2
1995 3
1996 2
1997 6
1998 3
1999 4
2000 5
2001 4
2002 2
2003 13
2004 7
2005 9
2006 15
2007 8
2008 9
2009 12
2010 8
2011 9
2012 9
2013 14
2014 11
2015 16
2016 21
2017 34
2018 23
2019 27
2020 25
2021 33
2022 29
2023 35
2024 8

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369 results

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Page 1
Vasopressor therapy in critically ill patients with shock.
Russell JA. Russell JA. Intensive Care Med. 2019 Nov;45(11):1503-1517. doi: 10.1007/s00134-019-05801-z. Epub 2019 Oct 23. Intensive Care Med. 2019. PMID: 31646370 Review.
OBJECTIVES: The objectives are to review safety and efficacy of vasopressors, pathophysiology, agents that decrease vasopressor dose, predictive biomarkers, beta1-blockers, and directions for research. ...Angiotensin II and dopamine have limited indications. In future, …
OBJECTIVES: The objectives are to review safety and efficacy of vasopressors, pathophysiology, agents that decrease vasopressor dose, pre …
Vasopressor Therapy in the Intensive Care Unit.
Russell JA, Gordon AC, Williams MD, Boyd JH, Walley KR, Kissoon N. Russell JA, et al. Semin Respir Crit Care Med. 2021 Feb;42(1):59-77. doi: 10.1055/s-0040-1710320. Epub 2020 Aug 20. Semin Respir Crit Care Med. 2021. PMID: 32820475
Vasopressor adverse effects are excessive vasoconstriction causing organ ischemia/infarction, hyperglycemia, hyperlactatemia, tachycardia, and tachyarrhythmias. To date, no randomized controlled trial (RCT) of vasopressors has shown a decreased 28-day mortality rate. ...Ne …
Vasopressor adverse effects are excessive vasoconstriction causing organ ischemia/infarction, hyperglycemia, hyperlactatemia, tachyca …
Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction.
Levy B, Clere-Jehl R, Legras A, Morichau-Beauchant T, Leone M, Frederique G, Quenot JP, Kimmoun A, Cariou A, Lassus J, Harjola VP, Meziani F, Louis G, Rossignol P, Duarte K, Girerd N, Mebazaa A, Vignon P; Collaborators. Levy B, et al. J Am Coll Cardiol. 2018 Jul 10;72(2):173-182. doi: 10.1016/j.jacc.2018.04.051. J Am Coll Cardiol. 2018. PMID: 29976291 Free article. Clinical Trial.
Refractory CS was defined as CS with sustained hypotension, end-organ hypoperfusion and hyperlactatemia, and high inotrope and vasopressor doses. RESULTS: Fifty-seven patients were randomized into 2 study arms, epinephrine and norepinephrine. For the primary efficacy endpo …
Refractory CS was defined as CS with sustained hypotension, end-organ hypoperfusion and hyperlactatemia, and high inotrope and vasopr …
Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
PRISM Investigators; Rowan KM, Angus DC, Bailey M, Barnato AE, Bellomo R, Canter RR, Coats TJ, Delaney A, Gimbel E, Grieve RD, Harrison DA, Higgins AM, Howe B, Huang DT, Kellum JA, Mouncey PR, Music E, Peake SL, Pike F, Reade MC, Sadique MZ, Singer M, Yealy DM. PRISM Investigators, et al. N Engl J Med. 2017 Jun 8;376(23):2223-2234. doi: 10.1056/NEJMoa1701380. Epub 2017 Mar 21. N Engl J Med. 2017. PMID: 28320242 Free article.
BACKGROUND: After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. ...Subgroup analyses showed no benefit from …
BACKGROUND: After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortali …
Understanding Lactatemia in Human Sepsis. Potential Impact for Early Management.
Gattinoni L, Vasques F, Camporota L, Meessen J, Romitti F, Pasticci I, Duscio E, Vassalli F, Forni LG, Payen D, Cressoni M, Zanella A, Latini R, Quintel M, Marini JJ. Gattinoni L, et al. Am J Respir Crit Care Med. 2019 Sep 1;200(5):582-589. doi: 10.1164/rccm.201812-2342OC. Am J Respir Crit Care Med. 2019. PMID: 30985210 Free article. Clinical Trial.
Rationale: Hyperlactatemia in sepsis may derive from a prevalent impairment of oxygen supply/demand and/or oxygen use. ...Concomitant acidemia was only observed in the presence of renal dysfunction, as rapidly detected by alactic base excess. ...
Rationale: Hyperlactatemia in sepsis may derive from a prevalent impairment of oxygen supply/demand and/or oxygen use. ...Concomitant …
Sepsis-associated hyperlactatemia.
Garcia-Alvarez M, Marik P, Bellomo R. Garcia-Alvarez M, et al. Crit Care. 2014 Sep 9;18(5):503. doi: 10.1186/s13054-014-0503-3. Crit Care. 2014. PMID: 25394679 Free PMC article. Review.
There is overwhelming evidence that sepsis and septic shock are associated with hyperlactatemia (sepsis-associated hyperlactatemia (SAHL)). SAHL is a strong independent predictor of mortality and its presence and progression are widely appreciated by clinicia …
There is overwhelming evidence that sepsis and septic shock are associated with hyperlactatemia (sepsis-associated hyperlactatemia …
Comparison of 5% human albumin and normal saline for fluid resuscitation in sepsis induced hypotension among patients with cirrhosis (FRISC study): a randomized controlled trial.
Philips CA, Maiwall R, Sharma MK, Jindal A, Choudhury AK, Kumar G, Bhardwaj A, Mitra LG, Agarwal PM, Sarin SK. Philips CA, et al. Hepatol Int. 2021 Aug;15(4):983-994. doi: 10.1007/s12072-021-10164-z. Epub 2021 May 25. Hepatol Int. 2021. PMID: 34036519 Clinical Trial.
Reversal of hypotension was higher in patients receiving 5% albumin than saline at the end of one hour [25.3% and 11.7%, p = 0.03, Odds ratio (95% CI)-1.9 (1.08-3.42)] and at the end of three hours [11.7% and 3.2%, p = 0.008, 3.9 (1.42-10.9)]. Sustained reduction in heart rate an …
Reversal of hypotension was higher in patients receiving 5% albumin than saline at the end of one hour [25.3% and 11.7%, p = 0.03, Odds rati …
How to assess tissue oxygenation?
De Backer D, Ospina-Tascón GA. De Backer D, et al. Curr Opin Crit Care. 2023 Jun 1;29(3):244-251. doi: 10.1097/MCC.0000000000001046. Epub 2023 Apr 6. Curr Opin Crit Care. 2023. PMID: 37078638 Review.
PO2 measurements, while attractive, are unfortunately of limited value in the presence of microvascular blood flow heterogeneity which is observed in many critically ill conditions including sepsis. Surrogates of tissue oxygenation are hence used. Elevated lactate levels m …
PO2 measurements, while attractive, are unfortunately of limited value in the presence of microvascular blood flow heterogeneity which is …
Microcirculation in sepsis: new perspectives.
Hernandez G, Bruhn A, Ince C. Hernandez G, et al. Curr Vasc Pharmacol. 2013 Mar 1;11(2):161-9. Curr Vasc Pharmacol. 2013. PMID: 23506495 Review.
Severity and persistence of these microcirculatory abnormalities are associated with bad prognosis and are not necessarily predicted by systemic variables. The introduction of bedside techniques that allow evaluation of the microcirculation into clinical practice has opene …
Severity and persistence of these microcirculatory abnormalities are associated with bad prognosis and are not necessarily predicted …
Hyperlactatemia in diabetic ketoacidosis.
Masharani U, Strycker LA, Lazar AA, Wu K, Brooks GA. Masharani U, et al. Diabet Med. 2022 Apr;39(4):e14723. doi: 10.1111/dme.14723. Epub 2021 Oct 22. Diabet Med. 2022. PMID: 34655270
AIMS: The study examined the prevalence and degree of lactate elevation in diabetic ketoacidosis, and explored which biochemical abnormalities predicted L-lactate levels. METHODS: We reviewed episodes of diabetic ketoacidosis from 79 diabetes patients (one episode per pati …
AIMS: The study examined the prevalence and degree of lactate elevation in diabetic ketoacidosis, and explored which biochemical abnormaliti …
369 results