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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 2
1975 2
1976 1
1978 2
1979 1
1980 1
1981 1
1982 1
1983 2
1984 1
1985 1
1987 1
1989 1
1990 2
1991 2
1993 2
1994 1
1996 1
1997 7
1998 1
2000 3
2001 8
2002 5
2003 31
2004 17
2005 9
2006 16
2007 14
2008 8
2009 5
2010 8
2011 7
2012 11
2013 13
2014 12
2015 23
2016 22
2017 38
2018 25
2019 19
2020 21
2021 26
2022 21
2023 19
2024 13

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385 results

Results by year

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Page 1
Vasopressor therapy in critically ill patients with shock.
Russell JA. Russell JA. Intensive Care Med. 2019 Nov;45(11):1503-1517. doi: 10.1007/s00134-019-05801-z. Epub 2019 Oct 23. Intensive Care Med. 2019. PMID: 31646370 Review.
Adverse effects include excessive vasoconstriction, organ ischemia, hyperglycemia, hyperlactatemia, tachycardia, and tachyarrhythmias. No randomized controlled trials of vasopressors showed a significant difference in 28-day mortality rate. ...
Adverse effects include excessive vasoconstriction, organ ischemia, hyperglycemia, hyperlactatemia, tachycardia, and tachyarrhythmias …
Review of Biguanide (Metformin) Toxicity.
Wang GS, Hoyte C. Wang GS, et al. J Intensive Care Med. 2019 Nov-Dec;34(11-12):863-876. doi: 10.1177/0885066618793385. Epub 2018 Aug 21. J Intensive Care Med. 2019. PMID: 30126348 Review.
The dominant source of metabolic acidosis associated with hyperlactatemia in metformin toxicity is the rapid cytosolic adenosine triphosphate (ATP) turnover when complex I is inhibited and oxidative phosphorylation cannot adequately recycle the vast quantity of H+ from ATP …
The dominant source of metabolic acidosis associated with hyperlactatemia in metformin toxicity is the rapid cytosolic adenosine trip …
Lactic acidosis.
Kraut JA, Madias NE. Kraut JA, et al. N Engl J Med. 2014 Dec 11;371(24):2309-19. doi: 10.1056/NEJMra1309483. N Engl J Med. 2014. PMID: 25494270 Review. No abstract available.
Vasopressor Therapy in the Intensive Care Unit.
Russell JA, Gordon AC, Williams MD, Boyd JH, Walley KR, Kissoon N. Russell JA, et al. Semin Respir Crit Care Med. 2021 Feb;42(1):59-77. doi: 10.1055/s-0040-1710320. Epub 2020 Aug 20. Semin Respir Crit Care Med. 2021. PMID: 32820475
Vasopressor adverse effects are excessive vasoconstriction causing organ ischemia/infarction, hyperglycemia, hyperlactatemia, tachycardia, and tachyarrhythmias. To date, no randomized controlled trial (RCT) of vasopressors has shown a decreased 28-day mortali …
Vasopressor adverse effects are excessive vasoconstriction causing organ ischemia/infarction, hyperglycemia, hyperlactatemia, tachyca …
Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction.
Levy B, Clere-Jehl R, Legras A, Morichau-Beauchant T, Leone M, Frederique G, Quenot JP, Kimmoun A, Cariou A, Lassus J, Harjola VP, Meziani F, Louis G, Rossignol P, Duarte K, Girerd N, Mebazaa A, Vignon P; Collaborators. Levy B, et al. J Am Coll Cardiol. 2018 Jul 10;72(2):173-182. doi: 10.1016/j.jacc.2018.04.051. J Am Coll Cardiol. 2018. PMID: 29976291 Free article. Clinical Trial.
Although norepinephrine and epinephrine are currently the most commonly used agents, no randomized trial has compared their effects, and intervention data are lacking. ...Refractory CS was defined as CS with sustained hypotension, end-organ hypoperfusion and hype …
Although norepinephrine and epinephrine are currently the most commonly used agents, no randomized trial has compared their ef …
Medication-Induced Hyperlactatemia and Lactic Acidosis: A Systematic Review of the Literature.
Smith ZR, Horng M, Rech MA. Smith ZR, et al. Pharmacotherapy. 2019 Sep;39(9):946-963. doi: 10.1002/phar.2316. Epub 2019 Aug 29. Pharmacotherapy. 2019. PMID: 31361914
Hyperlactatemia and lactic acidosis are two syndromes that are associated with morbidity and mortality. Medication-induced hyperlactatemia and lactic acidosis are diagnoses of exclusion and have the potential to be overlooked. ...
Hyperlactatemia and lactic acidosis are two syndromes that are associated with morbidity and mortality. Medication-induced hyperla …
What Is the Utility of Measuring Lactate Levels in Patients with Sepsis and Septic Shock?
Weinberger J, Klompas M, Rhee C. Weinberger J, et al. Semin Respir Crit Care Med. 2021 Oct;42(5):650-661. doi: 10.1055/s-0041-1733915. Epub 2021 Sep 20. Semin Respir Crit Care Med. 2021. PMID: 34544182 Review.
More broadly, there is a lack of high-quality evidence demonstrating that initial and serial lactate monitoring leads to better patient-centered outcomes. Indeed, a recent randomized controlled trial comparing resuscitation strategies based on lactate clearance vers …
More broadly, there is a lack of high-quality evidence demonstrating that initial and serial lactate monitoring leads to better patient-cent …
Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis.
PRISM Investigators; Rowan KM, Angus DC, Bailey M, Barnato AE, Bellomo R, Canter RR, Coats TJ, Delaney A, Gimbel E, Grieve RD, Harrison DA, Higgins AM, Howe B, Huang DT, Kellum JA, Mouncey PR, Music E, Peake SL, Pike F, Reade MC, Sadique MZ, Singer M, Yealy DM. PRISM Investigators, et al. N Engl J Med. 2017 Jun 8;376(23):2223-2234. doi: 10.1056/NEJMoa1701380. Epub 2017 Mar 21. N Engl J Med. 2017. PMID: 28320242 Free article.
BACKGROUND: After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. ...After completion of the trials, we pooled …
BACKGROUND: After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortali …
Severe Sepsis and Septic Shock Trials (ProCESS, ARISE, ProMISe): What is Optimal Resuscitation?
Osborn TM. Osborn TM. Crit Care Clin. 2017 Apr;33(2):323-344. doi: 10.1016/j.ccc.2016.12.004. Crit Care Clin. 2017. PMID: 28284298 Review.
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in severe sepsis and septic shock: Protocolized Care for Early Septic Shock (ProCESS) from the United States; Australasian Resuscitation in Sepsis E …
Between 2014 and 2015, 3 independent, multicenter, randomized controlled trials evaluated early goal-directed therapy (EGDT) in sever …
New Insights into the Fluid Management in Patients with Septic Shock.
Moschopoulos CD, Dimopoulou D, Dimopoulou A, Dimopoulou K, Protopapas K, Zavras N, Tsiodras S, Kotanidou A, Fragkou PC. Moschopoulos CD, et al. Medicina (Kaunas). 2023 May 29;59(6):1047. doi: 10.3390/medicina59061047. Medicina (Kaunas). 2023. PMID: 37374251 Free PMC article. Review.
Current Surviving Sepsis Campaign (SSC) guidelines recommend the early administration of intravenous crystalloid fluids for sepsis-related hypotension or hyperlactatemia due to tissue hypoperfusion, within the first 3 h of resuscitation and suggest using balanced solutions …
Current Surviving Sepsis Campaign (SSC) guidelines recommend the early administration of intravenous crystalloid fluids for sepsis-related h …
385 results