Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors.
Amaravadi RK, Hamilton KE, Ma X, Piao S, Portillo AD, Nathanson KL, Carlino MS, Long GV, Puzanov I, Xu X, Morrissette JJ, Tsai KY, Flaherty KT, Sosman JA, Goodman GR, McArthur GA, Rustgi AK, Metz DC, Schuchter LM, Chapman PB, Sepulveda AR.
Amaravadi RK, et al.
Clin Cancer Res. 2015 Dec 1;21(23):5215-21. doi: 10.1158/1078-0432.CCR-15-0469. Epub 2015 Jul 22.
Clin Cancer Res. 2015.
PMID: 26202952
Free PMC article.
One patient presented with bleeding from hyperplastic gastric polyps that recurred 6 months after BRAFi rechallenge. ...No polyps were observed in BRAFi-treated wild-type mice. CONCLUSIONS: BRAFi may increase the risk of developing hyperplastic gastric polyps and …
One patient presented with bleeding from hyperplastic gastric polyps that recurred 6 months after BRAFi rechallenge. ...No polyps wer …