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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1983 4
1984 2
1988 1
1993 2
1994 1
1995 3
1996 3
1997 1
1998 2
1999 5
2000 1
2002 1
2003 2
2004 1
2005 2
2008 3
2009 2
2010 1
2011 3
2012 1
2013 2
2015 1
2016 1
2017 1
2024 0

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46 results

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Page 1
DNA hyperploidy as a marker for biological response to bladder carcinogen exposure.
Hemstreet GP, Schulte PA, Ringen K, Stringer W, Altekruse EB. Hemstreet GP, et al. Int J Cancer. 1988 Dec 15;42(6):817-20. doi: 10.1002/ijc.2910420602. Int J Cancer. 1988. PMID: 3192323
A quantitative fluorescence cytology method using the DNA-binding dye, acridine orange, was employed to measure DNA in exfoliated urothelial cells. DNA hyperploidy (greater than 5 C) was observed in 16 (21.6%) of 74 workers who had been exposed compared with 15 (3.5 …
A quantitative fluorescence cytology method using the DNA-binding dye, acridine orange, was employed to measure DNA in exfoliated urothelial …
A cell-based model system links chromothripsis with hyperploidy.
Mardin BR, Drainas AP, Waszak SM, Weischenfeldt J, Isokane M, Stütz AM, Raeder B, Efthymiopoulos T, Buccitelli C, Segura-Wang M, Northcott P, Pfister SM, Lichter P, Ellenberg J, Korbel JO. Mardin BR, et al. Mol Syst Biol. 2015 Sep 28;11(9):828. doi: 10.15252/msb.20156505. Mol Syst Biol. 2015. PMID: 26415501 Free PMC article.
A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one-off genomic catastrophe, resulting in massive somatic DNA structural rearrangements (SRs). ...Analysis of primary medulloblastoma cancer genomes verified t …
A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one-off genomic cat …
Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus.
Doak SH, Jenkins GJ, Parry EM, D'Souza FR, Griffiths AP, Toffazal N, Shah V, Baxter JN, Parry JM. Doak SH, et al. Gut. 2003 May;52(5):623-8. doi: 10.1136/gut.52.5.623. Gut. 2003. PMID: 12692043 Free PMC article.
RESULTS: Aneuploidy was found early in progression, with metaplastic tissues displaying increased copy numbers of chromosomes 4 and 8. Chromosome 4 hyperploidy was found in 89%, 90%, 88%, and 100% of metaplasias, LGD, HGD, adenocarcinomas, respectively, while chromosome 8 …
RESULTS: Aneuploidy was found early in progression, with metaplastic tissues displaying increased copy numbers of chromosomes 4 and 8. Chrom …
Sequence of molecular genetic events in colorectal tumorigenesis.
Laurent-Puig P, Blons H, Cugnenc PH. Laurent-Puig P, et al. Eur J Cancer Prev. 1999 Dec;8 Suppl 1:S39-47. Eur J Cancer Prev. 1999. PMID: 10772417 Review.
The first group, named LOH (for loss of heterozygosity)-positive, is characterized by hyperploidy and allelic losses involving preferentially chromosome 18q and chromosome 17p. ...LOH-positive tumours activate the WNT/Wingless signalling pathway through an adenomatous poly …
The first group, named LOH (for loss of heterozygosity)-positive, is characterized by hyperploidy and allelic losses involving prefer …
Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma.
Tavanti E, Sero V, Vella S, Fanelli M, Michelacci F, Landuzzi L, Magagnoli G, Versteeg R, Picci P, Hattinger CM, Serra M. Tavanti E, et al. Br J Cancer. 2013 Nov 12;109(10):2607-18. doi: 10.1038/bjc.2013.643. Epub 2013 Oct 15. Br J Cancer. 2013. PMID: 24129234 Free PMC article.
RESULTS: Human osteosarcoma cell lines proved to be highly sensitive to both drugs. A decreased drug sensitivity was observed in doxorubicin-resistant cell lines, most probably related to ABCB1/MDR1 overexpression. Both drugs variably induced hyperploidy and apoptos …
RESULTS: Human osteosarcoma cell lines proved to be highly sensitive to both drugs. A decreased drug sensitivity was observed in doxo …
Cell trivision of hyperploid cells.
Nagy G, Kiraly G, Turani M, Banfalvi G. Nagy G, et al. DNA Cell Biol. 2013 Dec;32(12):676-84. doi: 10.1089/dna.2013.2147. Epub 2013 Oct 5. DNA Cell Biol. 2013. PMID: 24093497 Free PMC article.
The occurrence of trivision was significantly lower in near-diploid endothelial cells (1:1400, 0.07%). We have previously observed the phenomenon of trivision in HaCaT cells treated with heavy metal lead, and here we describe that trivision is a spontaneous process taking …
The occurrence of trivision was significantly lower in near-diploid endothelial cells (1:1400, 0.07%). We have previously observed th …
Imagestream detection and characterisation of circulating tumour cells - A liquid biopsy for hepatocellular carcinoma?
Ogle LF, Orr JG, Willoughby CE, Hutton C, McPherson S, Plummer R, Boddy AV, Curtin NJ, Jamieson D, Reeves HL. Ogle LF, et al. J Hepatol. 2016 Aug;65(2):305-13. doi: 10.1016/j.jhep.2016.04.014. Epub 2016 Apr 27. J Hepatol. 2016. PMID: 27132171
CONCLUSIONS: The use of multiple parameters enhanced HCC CTC detection sensitivity, revealing biological associations and predictive biomarker potential that may be able to guide stratified medicine decisions and future research. LAY SUMMARY: Characteristics of tumour tiss …
CONCLUSIONS: The use of multiple parameters enhanced HCC CTC detection sensitivity, revealing biological associations and predictive …
DNA ploidy, nuclear size, proliferation index and DNA-hypomethylation in ovarian cancer.
Zeimet AG, Fiegl H, Goebel G, Kopp F, Allasia C, Reimer D, Steppan I, Mueller-Holzner E, Ehrlich M, Marth C. Zeimet AG, et al. Gynecol Oncol. 2011 Apr;121(1):24-31. doi: 10.1016/j.ygyno.2010.12.332. Epub 2011 Jan 20. Gynecol Oncol. 2011. PMID: 21251700 Free PMC article.
OBJECTIVE: The present study was undertaken to analyze the impact of epigenetic alterations with a main focus on nuclear area, aneuploidy, hyperploidy, and proliferation in 70 ovarian cancer specimens. METHODS: Morphometric changes and somatic chromosomal ploidy status wer …
OBJECTIVE: The present study was undertaken to analyze the impact of epigenetic alterations with a main focus on nuclear area, aneuploidy, …
Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma.
Smida J, Xu H, Zhang Y, Baumhoer D, Ribi S, Kovac M, von Luettichau I, Bielack S, O'Leary VB, Leib-Mösch C, Frishman D, Nathrath M. Smida J, et al. Int J Cancer. 2017 Aug 15;141(4):816-828. doi: 10.1002/ijc.30778. Epub 2017 May 25. Int J Cancer. 2017. PMID: 28494505 Free article.
It is characterized by highly complex karyotypes with structural and numerical chromosomal alterations. The observed OS-specific characteristics in localization and frequencies of chromosomal breakages strongly implicate a specific set of responsible driver genes or a spec …
It is characterized by highly complex karyotypes with structural and numerical chromosomal alterations. The observed OS-specific char …
Meiotic non-disjunction mechanisms in human fertile males.
Uroz L, Templado C. Uroz L, et al. Hum Reprod. 2012 May;27(5):1518-24. doi: 10.1093/humrep/des051. Epub 2012 Mar 1. Hum Reprod. 2012. PMID: 22381620
The frequency of numerical chromosome abnormalities at MII (14.5%) was 5.5 times higher than at MI (2.5%). We observed 88 (27.7%) spermatocytes I with chromosome bivalents with a low chiasma count, usually small chromosomes displaying two separated univalents. Chromosomes …
The frequency of numerical chromosome abnormalities at MII (14.5%) was 5.5 times higher than at MI (2.5%). We observed 88 (27.7%) spe …
46 results