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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 2
1989 1
1990 1
1991 1
1992 1
1993 1
1995 1
1996 1
1997 1
1998 1
1999 1
2003 1
2004 2
2005 1
2006 2
2008 1
2009 1
2010 1
2011 2
2014 1
2015 1
2018 1
2021 1
2022 1
2024 0

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28 results

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Page 1
Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet beta-cell dysfunction?
Porte D Jr, Kahn SE. Porte D Jr, et al. Diabetes. 1989 Nov;38(11):1333-6. doi: 10.2337/diab.38.11.1333. Diabetes. 1989. PMID: 2695369 Review.
Because of its association with two apparently dissimilar disease states, we propose a hypothesis that encompasses the observations related to proinsulin and islet amyloid polypeptide and suggest they are manifestations of the same abnormality. ...
Because of its association with two apparently dissimilar disease states, we propose a hypothesis that encompasses the observations r …
Circulating proinsulin-like molecules.
Yudkin JS. Yudkin JS. J Diabetes Complications. 1993 Apr-Jun;7(2):113-23. doi: 10.1016/1056-8727(93)90036-x. J Diabetes Complications. 1993. PMID: 8518453 Review.
Levels of proinsulin-like molecules are elevated in subjects who have NIDDM or impaired glucose tolerance. However, the observation that hyperproinsulinemia may occur in individuals without hyperglycemia suggests that elevated proinsulin levels may be a manifestatio …
Levels of proinsulin-like molecules are elevated in subjects who have NIDDM or impaired glucose tolerance. However, the observation t …
Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men.
Risérus U, Arnlöv J, Brismar K, Zethelius B, Berglund L, Vessby B. Risérus U, et al. Diabetes Care. 2004 Aug;27(8):2041-6. doi: 10.2337/diacare.27.8.2041. Diabetes Care. 2004. PMID: 15277437
OBJECTIVE: It is clinically important to find noninvasive markers of insulin resistance and hyperproinsulinemia because they both predict cardiovascular and diabetes risk. ...In multiple regression analyses, including all anthropometric measures, SAD was the only in …
OBJECTIVE: It is clinically important to find noninvasive markers of insulin resistance and hyperproinsulinemia because they both …
Beta-cell function is disrupted in patients with systemic lupus erythematosus.
García-Dorta A, Quevedo-Abeledo JC, Rua-Figueroa Í, de Vera-González AM, González-Delgado A, Medina-Vega L, González-Rivero AF, Francisco-Hernández F, González-Gay MA, Ferraz-Amaro I. García-Dorta A, et al. Rheumatology (Oxford). 2021 Aug 2;60(8):3826-3833. doi: 10.1093/rheumatology/keaa874. Rheumatology (Oxford). 2021. PMID: 33369681
Similar results were found for the intact proinsulin-to-insulin ratio, although differences were only statistically significant for patients taking glucocorticoids [beta coef. 0.08 (95% CI: 0.03, 0.12), P = 0.001]. SLE damage score was associated with higher serum levels o …
Similar results were found for the intact proinsulin-to-insulin ratio, although differences were only statistically significant for patients …
The impact of insulin resistance on proinsulin secretion in pregnancy: hyperproinsulinemia is not a feature of gestational diabetes.
Retnakaran R, Hanley AJ, Sermer M, Zinman B. Retnakaran R, et al. Diabetes Care. 2005 Nov;28(11):2710-5. doi: 10.2337/diacare.28.11.2710. Diabetes Care. 2005. PMID: 16249544
Thus, we sought to determine whether GDM is characterized by relative hyperproinsulinemia as measured by the proinsulin-to-C-peptide ratio, an alternate measure of proinsulin secretion that is not affected by hepatic insulin extraction. ...CONCLUSIONS: GDM is not independe …
Thus, we sought to determine whether GDM is characterized by relative hyperproinsulinemia as measured by the proinsulin-to-C-peptide …
Hyperproinsulinemia in a family with a proposed defect in conversion is linked to the insulin gene.
Elbein SC, Gruppuso P, Schwartz R, Skolnick M, Permutt MA. Elbein SC, et al. Diabetes. 1985 Aug;34(8):821-4. doi: 10.2337/diab.34.8.821. Diabetes. 1985. PMID: 2991050
Two previously described pedigrees with familial hyperproinsulinemia have elevated proinsulin conversion intermediates resulting from amino acid substitutions in the proinsulin molecule. ...To determine if the defect in this family lies in the insulin gene region, we used …
Two previously described pedigrees with familial hyperproinsulinemia have elevated proinsulin conversion intermediates resulting from …
Increased β-Cell Workload Modulates Proinsulin-to-Insulin Ratio in Humans.
Mezza T, Ferraro PM, Sun VA, Moffa S, Cefalo CMA, Quero G, Cinti F, Sorice GP, Pontecorvi A, Folli F, Mari A, Alfieri S, Giaccari A. Mezza T, et al. Diabetes. 2018 Nov;67(11):2389-2396. doi: 10.2337/db18-0279. Epub 2018 Aug 21. Diabetes. 2018. PMID: 30131390 Free article.
An alternative way to investigate the relation between relative hyperproinsulinemia and increased secretory demand is to study the dynamic changes in the proinsulin-to-insulin ratio after partial pancreatectomy, a model of acute increased beta-cell workload on the remainin …
An alternative way to investigate the relation between relative hyperproinsulinemia and increased secretory demand is to study the dy …
Association of Fasting Proinsulin Levels with Glycemic Profile in Indian Type 2 Diabetes Patients.
Aggarwal A, Chaudhury D, Singh R. Aggarwal A, et al. J Assoc Physicians India. 2022 Apr;70(4):11-12. J Assoc Physicians India. 2022. PMID: 35443363
Type 2 diabetes mellitus is a major cause of cardiovascular disease and mortality, with mortality rate 27% higher in the diabetes cohort. Hyperproinsulinemia is a sign of beta cell dysfunction that is augmented by the increased demands placed on beta cell by chronic hyperg …
Type 2 diabetes mellitus is a major cause of cardiovascular disease and mortality, with mortality rate 27% higher in the diabetes cohort. …
Risk factors for the development of NIDDM in Yonchon County, Korea.
Shin CS, Lee HK, Koh CS, Kim YI, Shin YS, Yoo KY, Paik HY, Park YS, Yang BG. Shin CS, et al. Diabetes Care. 1997 Dec;20(12):1842-6. doi: 10.2337/diacare.20.12.1842. Diabetes Care. 1997. PMID: 9405904
Age, sex, and anthropometric and metabolic characteristics at baseline were analyzed simultaneously as potential predictors of conversion to NIDDM. We also designed a nested case-control study to determine the role of hyperinsulinemia and/or hyperproinsulinemia in t …
Age, sex, and anthropometric and metabolic characteristics at baseline were analyzed simultaneously as potential predictors of conver …
Proinsulin as a marker for the development of NIDDM in Japanese-American men.
Kahn SE, Leonetti DL, Prigeon RL, Boyko EJ, Bergstrom RW, Fujimoto WY. Kahn SE, et al. Diabetes. 1995 Feb;44(2):173-9. doi: 10.2337/diab.44.2.173. Diabetes. 1995. PMID: 7859937
Disproportionate hyperproinsulinemia is one manifestation of the B-cell dysfunction observed in non-insulin-dependent diabetes mellitus (NIDDM), but it is unclear when this abnormality develops and whether it predicts the development of NIDDM. ...At baseline, …
Disproportionate hyperproinsulinemia is one manifestation of the B-cell dysfunction observed in non-insulin-dependent diabetes …
28 results