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Page 1
Proinsulin and C-peptide: a review.
Kitabchi AE. Kitabchi AE. Metabolism. 1977 May;26(5):547-87. doi: 10.1016/0026-0495(77)90099-3. Metabolism. 1977. PMID: 403392 Review.
These results, which are comparable to those obtained by the more laborious column chromatography, could be summarized as follows: (1) proinsulin values in lean, young normal subjects do not vary greatly in response to insulin secretagogues; (2) proinsulin secretion in response t …
These results, which are comparable to those obtained by the more laborious column chromatography, could be summarized as follows: (1) proin …
Circulating proinsulin-like molecules.
Yudkin JS. Yudkin JS. J Diabetes Complications. 1993 Apr-Jun;7(2):113-23. doi: 10.1016/1056-8727(93)90036-x. J Diabetes Complications. 1993. PMID: 8518453 Review.
Levels of proinsulin-like molecules are elevated in subjects who have NIDDM or impaired glucose tolerance. However, the observation that hyperproinsulinemia may occur in individuals without hyperglycemia suggests that elevated proinsulin levels may be a manifestation of be …
Levels of proinsulin-like molecules are elevated in subjects who have NIDDM or impaired glucose tolerance. However, the observation that …
Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men.
Risérus U, Arnlöv J, Brismar K, Zethelius B, Berglund L, Vessby B. Risérus U, et al. Diabetes Care. 2004 Aug;27(8):2041-6. doi: 10.2337/diacare.27.8.2041. Diabetes Care. 2004. PMID: 15277437
OBJECTIVE: It is clinically important to find noninvasive markers of insulin resistance and hyperproinsulinemia because they both predict cardiovascular and diabetes risk. ...In multiple regression analyses, including all anthropometric measures, SAD was the only independe …
OBJECTIVE: It is clinically important to find noninvasive markers of insulin resistance and hyperproinsulinemia because they both pre …
Beta-cell function is disrupted in patients with systemic lupus erythematosus.
García-Dorta A, Quevedo-Abeledo JC, Rua-Figueroa Í, de Vera-González AM, González-Delgado A, Medina-Vega L, González-Rivero AF, Francisco-Hernández F, González-Gay MA, Ferraz-Amaro I. García-Dorta A, et al. Rheumatology (Oxford). 2021 Aug 2;60(8):3826-3833. doi: 10.1093/rheumatology/keaa874. Rheumatology (Oxford). 2021. PMID: 33369681
CONCLUSION: Among patients with SLE, proinsulin-processing metabolites, a marker of beta-cell disruption, are upregulated compared with matched controls. This disproportionate hyperproinsulinemia can be explained by the damage produced by the disease and occurs independent …
CONCLUSION: Among patients with SLE, proinsulin-processing metabolites, a marker of beta-cell disruption, are upregulated compared with matc …
Hyperproinsulinemia is not a characteristic feature in the offspring of patients with different phenotypes of type II diabetes.
Vauhkonen IK, Niskanen LK, Mykkänen L, Haffner SM, Uusitupa MI, Laakso M. Vauhkonen IK, et al. Eur J Endocrinol. 2000 Aug;143(2):251-60. doi: 10.1530/eje.0.1430251. Eur J Endocrinol. 2000. PMID: 10913945
In stepwise multiple regression analysis, hepatic specific insulin extraction in the fasting state (beta =0.65; P<0.001) and fasting blood glucose (beta =0.32; P<0.05) together explained 52% of the variation in fasting plasma proinsulin-to-specific insulin ratio. CONCLUSION …
In stepwise multiple regression analysis, hepatic specific insulin extraction in the fasting state (beta =0.65; P<0.001) and fasting bloo …
The impact of insulin resistance on proinsulin secretion in pregnancy: hyperproinsulinemia is not a feature of gestational diabetes.
Retnakaran R, Hanley AJ, Sermer M, Zinman B. Retnakaran R, et al. Diabetes Care. 2005 Nov;28(11):2710-5. doi: 10.2337/diacare.28.11.2710. Diabetes Care. 2005. PMID: 16249544
Thus, we sought to determine whether GDM is characterized by relative hyperproinsulinemia as measured by the proinsulin-to-C-peptide ratio, an alternate measure of proinsulin secretion that is not affected by hepatic insulin extraction. ...CONCLUSIONS: GDM is not independe …
Thus, we sought to determine whether GDM is characterized by relative hyperproinsulinemia as measured by the proinsulin-to-C-peptide …
Intact proinsulin and beta-cell function in lean and obese subjects with and without type 2 diabetes.
Røder ME, Dinesen B, Hartling SG, Houssa P, Vestergaard H, Sodoyez-Goffaux F, Binder C. Røder ME, et al. Diabetes Care. 1999 Apr;22(4):609-14. doi: 10.2337/diacare.22.4.609. Diabetes Care. 1999. PMID: 10189540
OBJECTIVE: Type 2 diabetes is a heterogeneous disease in which both beta-cell dysfunction and insulin resistance are pathogenetic factors. Disproportionate hyperproinsulinemia (elevated proinsulin/insulin) is another abnormality in type 2 diabetes whose mechanism is unknow …
OBJECTIVE: Type 2 diabetes is a heterogeneous disease in which both beta-cell dysfunction and insulin resistance are pathogenetic factors. D …
Beta-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults.
Elder DA, Prigeon RL, Wadwa RP, Dolan LM, D'Alessio DA. Elder DA, et al. J Clin Endocrinol Metab. 2006 Jan;91(1):185-91. doi: 10.1210/jc.2005-0853. Epub 2005 Nov 1. J Clin Endocrinol Metab. 2006. PMID: 16263830
However, the adolescent diabetic subjects retained a first-phase insulin response to glucose that was comparable to lean controls and did not have hyperproinsulinemia or hyperglucagonemia....
However, the adolescent diabetic subjects retained a first-phase insulin response to glucose that was comparable to lean controls and did no …
39 results