Mannitol pharmacokinetics and serum osmolality in dogs and humans.
Cloyd JC, Snyder BD, Cleeremans B, Bundlie SR, Blomquist CH, Lakatua DJ.
Cloyd JC, et al.
J Pharmacol Exp Ther. 1986 Feb;236(2):301-6.
J Pharmacol Exp Ther. 1986.
PMID: 3080582
The volume of distribution was 0.47 +/- 0.50 liters/kg and total body clearance was 7.15 +/- 10.23 ml X min-1 X kg-1. The disposition of mannitol in dogs is similar to that observed in humans. Mannitol clearance was independent of dose whereas the central compartment volum …
The volume of distribution was 0.47 +/- 0.50 liters/kg and total body clearance was 7.15 +/- 10.23 ml X min-1 X kg-1. The disposition of man …