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Page 1
Pathophysiology of Diuretic Resistance and Its Implications for the Management of Chronic Heart Failure.
Wilcox CS, Testani JM, Pitt B. Wilcox CS, et al. Hypertension. 2020 Oct;76(4):1045-1054. doi: 10.1161/HYPERTENSIONAHA.120.15205. Epub 2020 Aug 24. Hypertension. 2020. PMID: 32829662 Free PMC article. Review.
It is a major cause of recurrent hospitalizations in patients with chronic heart failure and predicts death but is difficult to diagnose unequivocally. Pharmacokinetic mechanisms include the low and variable bioavailability of furosemide and the short duration of all loop …
It is a major cause of recurrent hospitalizations in patients with chronic heart failure and predicts death but is difficult to diagn …
Hypochloremic metabolic alkalosis from ingestion of a chloride-deficient infant formula: outcome 9 and 10 years later.
Malloy MH, Graubard B, Moss H, McCarthy M, Gwyn S, Vietze P, Willoughby A, Rhoads GG, Berendes H. Malloy MH, et al. Pediatrics. 1991 Jun;87(6):811-22. Pediatrics. 1991. PMID: 2034484
In 1978 and 1979 two infant formulas, Neo-Mull-Soy and Cho-Free, were found to be deficient in chloride. The Centers for Disease Control received reports that hypochloremic metabolic alkalosis (HMA) had developed in 141 children as a result of exposure to the …
In 1978 and 1979 two infant formulas, Neo-Mull-Soy and Cho-Free, were found to be deficient in chloride. The Centers for Disease Control rec …
Acetazolamide Therapy for Metabolic Alkalosis in Pediatric Intensive Care Patients.
López C, Alcaraz AJ, Toledo B, Cortejoso L, Gil-Ruiz MA. López C, et al. Pediatr Crit Care Med. 2016 Dec;17(12):e551-e558. doi: 10.1097/PCC.0000000000000971. Pediatr Crit Care Med. 2016. PMID: 27748700
OBJECTIVE: Patients in PICUs frequently present hypochloremic metabolic alkalosis secondary to loop diuretic treatment, especially those undergoing cardiac surgery. This study evaluates the effectiveness of acetazolamide therapy for metabolic alkalosis in PIC …
OBJECTIVE: Patients in PICUs frequently present hypochloremic metabolic alkalosis secondary to loop diuretic treatment, …
Growth hormone deficiency in children with antenatal Bartter syndrome.
Spector-Cohen I, Koren A, Sakran W, Tenenbaum-Rakover Y, Halevy R. Spector-Cohen I, et al. J Pediatr Endocrinol Metab. 2019 Mar 26;32(3):225-231. doi: 10.1515/jpem-2018-0188. J Pediatr Endocrinol Metab. 2019. PMID: 30844761
Background Bartter syndrome is a group of rare autosomal-recessive renal disorders characterized by hypokalemic hypochloremic metabolic alkalosis associated with severe growth failure; the exact causes for growth retardation are unclear. ...The mean patient h …
Background Bartter syndrome is a group of rare autosomal-recessive renal disorders characterized by hypokalemic hypochloremic meta …
A patient with Bartter syndrome accompanying severe growth hormone deficiency and focal segmental glomerulosclerosis.
Akil I, Ozen S, Kandiloglu AR, Ersoy B. Akil I, et al. Clin Exp Nephrol. 2010 Jun;14(3):278-82. doi: 10.1007/s10157-009-0262-7. Epub 2010 Feb 4. Clin Exp Nephrol. 2010. PMID: 20127383
Bartter syndrome is a rare autosomal recessive, salt-losing disorder characterized by hypokalemic hypochloremic metabolic alkalosis. A 10-year-old boy had severe growth retardation (height standard deviation score -8.15). ...Serum sodium and chloride l …
Bartter syndrome is a rare autosomal recessive, salt-losing disorder characterized by hypokalemic hypochloremic metabolic a …
Pharmacokinetics and pharmacodynamics of bumetanide in critically ill pediatric patients.
Marshall JD, Wells TG, Letzig L, Kearns GL. Marshall JD, et al. J Clin Pharmacol. 1998 Nov;38(11):994-1002. doi: 10.1177/009127009803801102. J Clin Pharmacol. 1998. PMID: 9824779 Clinical Trial.
Unexpectedly, creatinine clearance increased dramatically after each dose. Adverse effects, including hypokalemia and hypochloremic metabolic alkalosis, were evident by the end of the treatment period. ...Pharmacokinetic parameters are similar to those previo …
Unexpectedly, creatinine clearance increased dramatically after each dose. Adverse effects, including hypokalemia and hypochloremic …
Exposure to a chloride-deficient formula during infancy: outcome at ages 9 and 10 years.
Malloy MH, Willoughby A, Graubard B, Lynch J, McCarthy M, Moss H, Vietze P, Rhoads G, Berendes H. Malloy MH, et al. Pediatrics. 1990 Oct;86(4):601-10. Pediatrics. 1990. PMID: 2216627
There was no correlation between duration of exclusive exposure to the chloride-deficient formulas and the Wechsler Intelligence Scale for Children-Revised Full-Scale IQ Score (Pearson product-moment r = -.0825, P = .28). These results cannot be extrapolated to exposed chi …
There was no correlation between duration of exclusive exposure to the chloride-deficient formulas and the Wechsler Intelligence Scale for C …