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Year Number of Results
2014 1
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2017 3
2018 2
2019 4
2020 4
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2023 3
2024 3

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27 results

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Page 1
Immune-related adverse events for anti-PD-1 and anti-PD-L1 drugs: systematic review and meta-analysis.
Baxi S, Yang A, Gennarelli RL, Khan N, Wang Z, Boyce L, Korenstein D. Baxi S, et al. BMJ. 2018 Mar 14;360:k793. doi: 10.1136/bmj.k793. BMJ. 2018. PMID: 29540345 Free PMC article. Review.
Serious organ specific immune-related adverse events were rare, but compared with standard treatment, rates of hypothyroidism (odds ratio 7.56, 95% confidence interval 4.53 to 12.61), pneumonitis (5.37, 2.73 to 10.56), colitis (2.88, 1.30 to 6.37), and hypophysitis (3.38, …
Serious organ specific immune-related adverse events were rare, but compared with standard treatment, rates of hypothyroidism (odds ratio 7. …
Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.
Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM. Barroso-Sousa R, et al. JAMA Oncol. 2018 Feb 1;4(2):173-182. doi: 10.1001/jamaoncol.2017.3064. JAMA Oncol. 2018. PMID: 28973656 Free PMC article.
MAIN OUTCOMES AND MEASURES: Incidence of all-grade hypothyroidism, hyperthyroidism, hypophysitis, primary adrenal insufficiency, and insulin-deficient diabetes. ...Patients on combination therapy are at increased risk of thyroid dysfunction and hypophysitis....
MAIN OUTCOMES AND MEASURES: Incidence of all-grade hypothyroidism, hyperthyroidism, hypophysitis, primary adrenal insufficiency, and …
Tumour- and class-specific patterns of immune-related adverse events of immune checkpoint inhibitors: a systematic review.
Khoja L, Day D, Wei-Wu Chen T, Siu LL, Hansen AR. Khoja L, et al. Ann Oncol. 2017 Oct 1;28(10):2377-2385. doi: 10.1093/annonc/mdx286. Ann Oncol. 2017. PMID: 28945858 Free article. Review.
Grade 3/4 irAE were more common with CTLA-4 mAbs compared with PD-1 (31% versus 10%). All grades colitis (OR 8.7, 95% CI 5.8-12.9), hypophysitis (OR 6.5, 95% CI 3.0-14.3) and rash (OR 2.0, 95% CI 1.8-2.3) were more frequent with CTLA-4 mAbs; whereas pneumonitis (OR 6.4, 95 …
Grade 3/4 irAE were more common with CTLA-4 mAbs compared with PD-1 (31% versus 10%). All grades colitis (OR 8.7, 95% CI 5.8-12.9), hypop …
Hypophysitis: A comprehensive overview.
de Vries F, van Furth WR, Biermasz NR, Pereira AM. de Vries F, et al. Presse Med. 2021 Dec;50(4):104076. doi: 10.1016/j.lpm.2021.104076. Epub 2021 Oct 21. Presse Med. 2021. PMID: 34687912
Hypophysitis usually presents with endocrine deficiencies, including diabetes insipidus, with varying patterns. ...This review provides an overview of the current knowledge on hypophysitis using an aetiology-based approach and provides the clinician with a stepwise …
Hypophysitis usually presents with endocrine deficiencies, including diabetes insipidus, with varying patterns. ...This review provid …
Frequency and clinical characteristics of hypophysitis and hypopituitarism in patients undergoing immunotherapy - A systematic review.
Jacques JP, Valadares LP, Moura AC, Oliveira MRF, Naves LA. Jacques JP, et al. Front Endocrinol (Lausanne). 2023 Feb 15;14:1091185. doi: 10.3389/fendo.2023.1091185. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36875457 Free PMC article.
In the cohort studies, the incidence of hypophysitis and hypopituitarism ranged from 0% to 27.59% and from 0% to 17.86%, respectively. ...The main magnetic resonance imaging (MRI) findings were enlargement of the pituitary gland and enhanced contrast uptake. The main sympt …
In the cohort studies, the incidence of hypophysitis and hypopituitarism ranged from 0% to 27.59% and from 0% to 17.86%, respectively …
Immune-related serious adverse events with immune checkpoint inhibitors: Systematic review and network meta-analysis.
Oliveira C, Mainoli B, Duarte GS, Machado T, Tinoco RG, Esperança-Martins M, Ferreira JJ, Costa J. Oliveira C, et al. Eur J Clin Pharmacol. 2024 May;80(5):677-684. doi: 10.1007/s00228-024-03647-z. Epub 2024 Feb 19. Eur J Clin Pharmacol. 2024. PMID: 38372756 Free PMC article. Review.
Primary outcome was overall irSAEs, and secondary outcomes were pneumonitis, colitis, hepatitis, hypophysitis, myocarditis, nephritis, and pancreatitis. We conducted Bayesian network meta-analyses, estimated absolute rates and ranked treatments according to the surface und …
Primary outcome was overall irSAEs, and secondary outcomes were pneumonitis, colitis, hepatitis, hypophysitis, myocarditis, nephritis …
Efficacy and safety of the combined use of ipilimumab and nivolumab for melanoma patients with brain metastases: a systematic review and meta-analysis.
Su M, Yang Y, Wang P. Su M, et al. Immunopharmacol Immunotoxicol. 2023 Dec;45(6):761-769. doi: 10.1080/08923973.2023.2215403. Epub 2023 May 25. Immunopharmacol Immunotoxicol. 2023. PMID: 37228242
Incidence of grade 3/4 adverse events in IN-treated MBM patients was: diarrhea or colitis (16%), hepatitis (15%), rash (8%), increased alanine transaminase (8%), increased aspartate aminotransferase (7%), increased lipase (6%), increased amylase (4%), fatigue (3%), hypophysiti …
Incidence of grade 3/4 adverse events in IN-treated MBM patients was: diarrhea or colitis (16%), hepatitis (15%), rash (8%), increased alani …
Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature.
Hunn BH, Martin WG, Simpson S Jr, Mclean CA. Hunn BH, et al. Pituitary. 2014 Aug;17(4):357-65. doi: 10.1007/s11102-013-0510-4. Pituitary. 2014. PMID: 23990347 Free PMC article. Review.
Idiopathic granulomatous hypophysitis (IGH) is a rare inflammatory disease of the pituitary. There is debate in the scientific literature as to whether IGH represents a continuum of disease with lymphocytic hypophysitis or has a distinct pathogenesis. ...
Idiopathic granulomatous hypophysitis (IGH) is a rare inflammatory disease of the pituitary. There is debate in the scientific litera …
Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis.
Bertrand A, Kostine M, Barnetche T, Truchetet ME, Schaeverbeke T. Bertrand A, et al. BMC Med. 2015 Sep 4;13:211. doi: 10.1186/s12916-015-0455-8. BMC Med. 2015. PMID: 26337719 Free PMC article. Review.
Described irAEs consisted of skin lesions (rash, pruritus, and vitiligo), colitis, and less frequently hepatitis, hypophysitis, thyroiditis, and some rare events such as sarcoidosis, uveitis, Guillain-Barre syndrome, immune-mediated cytopenia and polymyalgia rheumatic/Hort …
Described irAEs consisted of skin lesions (rash, pruritus, and vitiligo), colitis, and less frequently hepatitis, hypophysitis, thyro …
27 results