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Structure and significance of cytogenetic abnormalities in adult patients with Ph-negative acute lymphoblastic leukemia.
Piskunova IS, Obukhova TN, Parovichnikova EN, Kulikov SM, Troitskaya VV, Gavrilina OA, Savchenko VG. Piskunova IS, et al. Ter Arkh. 2018 Aug 17;90(7):30-37. doi: 10.26442/terarkh201890730-37. Ter Arkh. 2018. PMID: 30701920
Normal karyotype was found in 48.5% of them, chromosome aberrations in 51.5% (structural changes were found in 19.2%, hyperploidy in 27.2%, and hypoploidy in 5.1%). In 17.2% of patients complex karyotype abnormalities were found. ...
Normal karyotype was found in 48.5% of them, chromosome aberrations in 51.5% (structural changes were found in 19.2%, hyperploidy in 27.2%, …
Sensitization of human ovarian tumor cells by subtoxic CDDP to anti-fas antibody-mediated cytotoxicity and apoptosis.
Uslu R, Jewett A, Bonavida B. Uslu R, et al. Gynecol Oncol. 1996 Aug;62(2):282-91. doi: 10.1006/gyno.1996.0228. Gynecol Oncol. 1996. PMID: 8751562
Findings similar to those obtained in cytotoxicity were also obtained in apoptosis as determined by DNA hypoploidy and DNA fragmentation. The effect of CDDP-mediated sensitization to anti-Fas and cytotoxicity was compared to CDDP-mediated toxicity. ...
Findings similar to those obtained in cytotoxicity were also obtained in apoptosis as determined by DNA hypoploidy and DNA fragmentat …
Synoviocyte apoptosis may differentiate responder and non-responder patients to methotrexate treatment in rheumatoid arthritis.
Lee SY, Park SH, Lee SW, Lee SH, Son MK, Choi YH, Chung WT, Yoo YH. Lee SY, et al. Arch Pharm Res. 2014 Oct;37(10):1286-94. doi: 10.1007/s12272-014-0365-x. Epub 2014 Mar 24. Arch Pharm Res. 2014. PMID: 24988987 Clinical Trial.
The induction of apoptosis was determined by the quantification of DNA hypoploidy by flow cytometry, nuclear morphology, caspases activation, DNA electrophoresis, and mitochondrial membrane potential measurements. ...
The induction of apoptosis was determined by the quantification of DNA hypoploidy by flow cytometry, nuclear morphology, caspases act …
Immunoglobulin D multiple myeloma: response to therapy, survival, and prognostic factors in 75 patients.
Kim MK, Suh C, Lee DH, Min CK, Kim SJ, Kim K, Moon JH, Yoon SS, Lee GW, Kang HJ, Kim SH, Choi CW, Eom HS, Kwak JY, Kim HJ, Mun YC, Bang SM, Lee K, Shin HJ, Lee JH; Korean Multiple Myeloma Working Party. Kim MK, et al. Ann Oncol. 2011 Feb;22(2):411-6. doi: 10.1093/annonc/mdq393. Epub 2010 Aug 2. Ann Oncol. 2011. PMID: 20682550 Free article.
At a median follow-up time of 28.6 months, median overall survival (OS) was 18.5 months. Age, extramedullary plasmacytoma, del(13) or hypoploidy, serum beta(2) microglobulin level, and platelet count were significant prognostic factors for OS. ...
At a median follow-up time of 28.6 months, median overall survival (OS) was 18.5 months. Age, extramedullary plasmacytoma, del(13) or hyp …
Interphase fluorescence in situ hybridization in multiple myeloma and monoclonal gammopathy of undetermined significance without and with positive plasma cell identification: analysis of 192 cases from the Region of Southern Denmark.
Christensen JH, Abildgaard N, Plesner T, Nibe A, Nielsen O, Sørensen AG, Kerndrup GB; Leukemia/Lymphoma Study Group, Region of Southern Denmark. Christensen JH, et al. Cancer Genet Cytogenet. 2007 Apr 15;174(2):89-99. doi: 10.1016/j.cancergencyto.2006.11.015. Cancer Genet Cytogenet. 2007. PMID: 17452249
In four out of seven cases with either near-tetraploidy/triploidy or hypoploidy in the G-banded karyotypes, the modal number in the G-banded karyotypes could not be elucidated with certainty with i-FISH. ...
In four out of seven cases with either near-tetraploidy/triploidy or hypoploidy in the G-banded karyotypes, the modal number in the G …
Genetics of aneuoploidy in man reconsidered by banding studies.
Dallapiccola B, Calabro A, Di Franco C. Dallapiccola B, et al. Ric Clin Lab. 1978 Jul-Sep;8(3):113-23. doi: 10.1007/BF02904983. Ric Clin Lab. 1978. PMID: 746292
The fractions of the haploid genome that can be tolerated in three doses and in one dose approach 7 and 3%, respectively. Hypoploidy is more deleterious than hyperploidy. The phenotypic effects of aneuploidy result in an 'aneuploid syndrome' of developmental, mental and gr …
The fractions of the haploid genome that can be tolerated in three doses and in one dose approach 7 and 3%, respectively. Hypoploidy …
Leukaemic intermediate lymphocytic lymphomas: analysis of twelve cases diagnosed by morphology.
Criel A, Billiet J, Vandenberghe E, van den Berghe H, Louwagie A, Hidajat M, Vanhoof A. Criel A, et al. Leuk Lymphoma. 1992 Nov;8(4-5):381-7. doi: 10.3109/10428199209051018. Leuk Lymphoma. 1992. PMID: 1290963
Cytogenetic abnormalities were found in 8 patients all having t(11;14)(q13;q32). DNA analysis revealed a relatively high incidence of hypoploidy. At diagnosis all the patients (9 males, 5 females; median age 68) had a low degree of absolute lymphocytosis but the disease wa …
Cytogenetic abnormalities were found in 8 patients all having t(11;14)(q13;q32). DNA analysis revealed a relatively high incidence of hyp …
HLA class II signals sensitize B lymphocytes to apoptosis via Fas/CD95 by increasing FADD recruitment to activated Fas and activation of caspases.
Blancheteau V, Charron D, Mooney N. Blancheteau V, et al. Hum Immunol. 2002 May;63(5):375-83. doi: 10.1016/s0198-8859(02)00384-1. Hum Immunol. 2002. PMID: 11975981
Moreover, engagement of HLA class II molecules leads to signal transduction in the antigen presenting cell. Signaling via HLA-DR increases CD95 mediated hypoploidy in B-cell blasts. Given the importance of CD95 for the homeostasis of lymphocyte populations, we examined the …
Moreover, engagement of HLA class II molecules leads to signal transduction in the antigen presenting cell. Signaling via HLA-DR increases C …
Familial erythroleukemia: four cases of the Diguglielmo syndrome in close relatives.
Nissenblatt MJ, Bias W, Borgaonkar D, Dixon S, Cody RP. Nissenblatt MJ, et al. Johns Hopkins Med J. 1982 Jan;150(1):1-9. Johns Hopkins Med J. 1982. PMID: 6948132
Cytogenetics were normal in 18 relatives. One leukemic exhibited hypoploidy and a marker chromosome. The association of an immunoglobulin abnormality and enzymopathy in the leukemics and relatives alike suggests a hereditary susceptibility to the development of erythroleuk …
Cytogenetics were normal in 18 relatives. One leukemic exhibited hypoploidy and a marker chromosome. The association of an immunoglob …