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Quoted phrase not found in phrase index: "Immunoglobulin heavy chain deficiency"
Page 1
Human antibodies from transgenic mice.
Lonberg N, Huszar D. Lonberg N, et al. Int Rev Immunol. 1995;13(1):65-93. doi: 10.3109/08830189509061738. Int Rev Immunol. 1995. PMID: 7494109 Review.
We have used homologous recombination in ES cells to engineer B cell-deficient mice that are incapable of expressing endogenous immunoglobulin heavy and kappa light chain genes. ...These animals are also of interest for studying the normal processes of …
We have used homologous recombination in ES cells to engineer B cell-deficient mice that are incapable of expressing endogenous im …
RNA exosome drives early B cell development via noncoding RNA processing mechanisms.
Laffleur B, Batista CR, Zhang W, Lim J, Yang B, Rossille D, Wu L, Estrella J, Rothschild G, Pefanis E, Basu U. Laffleur B, et al. Sci Immunol. 2022 Jun 3;7(72):eabn2738. doi: 10.1126/sciimmunol.abn2738. Epub 2022 Jun 3. Sci Immunol. 2022. PMID: 35658015 Free PMC article.
We noticed increased expression of RNA exosome subunits during V(D)J recombination, whereas a B cell developmental blockade at the pro-B cell stage was observed in the different knockout mice, overlapping with a lack of productive rearrangements of VDJ genes at the Ig h …
We noticed increased expression of RNA exosome subunits during V(D)J recombination, whereas a B cell developmental blockade at the pro-B cel …
Biosynthesis, assembly and secretion of coagulation factor VIII.
Kaufman RJ, Pipe SW, Tagliavacca L, Swaroop M, Moussalli M. Kaufman RJ, et al. Blood Coagul Fibrinolysis. 1997 Dec;8 Suppl 2:S3-14. Blood Coagul Fibrinolysis. 1997. PMID: 9607108 Review.
Within the secretory pathway, factor VIII is processed to a heterodimer of the heavy chain (domains A1-A2-B) in a metal ion association with the light chain (domains A3-C1-C2). Upon secretion from the cell, von Willebrand factor binds the light chain o …
Within the secretory pathway, factor VIII is processed to a heterodimer of the heavy chain (domains A1-A2-B) in a metal ion as …
Clinical criteria for the diagnosis of vascular dementia.
Loeb C. Loeb C. Eur Neurol. 1988;28(2):87-92. doi: 10.1159/000116237. Eur Neurol. 1988. PMID: 3131146 Review.
The usual ancillary diagnostic investigations (biochemical tests, cerebrospinal fluid (CSF), EEG, CT, MRI, angiography) can rather easily identify brain disorders due to tumors, vascular malformations, hematomas, infections, toxins and drugs, deficiency diseases, normal-pr …
The usual ancillary diagnostic investigations (biochemical tests, cerebrospinal fluid (CSF), EEG, CT, MRI, angiography) can rather easily id …
Immunoglobulin G subclass deficiency: fact or fancy?
Buckley RH. Buckley RH. Curr Allergy Asthma Rep. 2002 Sep;2(5):356-60. doi: 10.1007/s11882-002-0067-1. Curr Allergy Asthma Rep. 2002. PMID: 12165200 Review.
Over the past four decades, many patients have been reported to have deficiencies of one or more subclasses of immunoglobulin G (IgG), despite normal total IgG serum concentrations. However, except for those with extremely low or absent IgG2 concentrations and an in …
Over the past four decades, many patients have been reported to have deficiencies of one or more subclasses of immunoglobulin …
Immunoglobulin heavy chain junctional diversity in young and aged humans.
Xue W, Luo S, Adler WH, Schulze DH, Berman JE. Xue W, et al. Hum Immunol. 1997 Oct;57(2):80-92. doi: 10.1016/s0198-8859(97)00184-5. Hum Immunol. 1997. PMID: 9438199
Since a major source of antibody diversity is generated at the VH-D-JH junctional regions of the immunoglobulin heavy chain, we determined whether differences in junctional diversity are manifested with aging. ...A PCR assay that measures CDR3 length in the m …
Since a major source of antibody diversity is generated at the VH-D-JH junctional regions of the immunoglobulin heavy chain …
Prognostic markers for immunodeficiency-associated primary central nervous system lymphoma.
Kaulen LD, Galluzzo D, Hui P, Barbiero F, Karschnia P, Huttner A, Fulbright R, Baehring JM. Kaulen LD, et al. J Neurooncol. 2019 Aug;144(1):107-115. doi: 10.1007/s11060-019-03208-w. Epub 2019 Jun 13. J Neurooncol. 2019. PMID: 31190317

Age > 60 years at diagnosis (p < 0.01), peripheral enhancement of the mass on MRI (p = 0.04), heterogeneous DWI patterns (p = 0.04), and clonal immunoglobulin heavy chain gene rearrangement (IgHR) (p = 0.03) were found to be negative prognostic markers.

…

Age > 60 years at diagnosis (p < 0.01), peripheral enhancement of the mass on MRI (p = 0.04), heterogeneous DWI patterns (p = 0.04), a

…
IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development.
Riva F, Ponzoni M, Supino D, Bertilaccio MTS, Polentarutti N, Massara M, Pasqualini F, Carriero R, Innocenzi A, Anselmo A, Veliz-Rodriguez T, Simonetti G, Anders HJ, Caligaris-Cappio F, Mantovani A, Muzio M, Garlanda C. Riva F, et al. Cancer Immunol Res. 2019 Jun;7(6):874-885. doi: 10.1158/2326-6066.CIR-18-0698. Epub 2019 Apr 24. Cancer Immunol Res. 2019. PMID: 31018956 Free PMC article.
We herein investigated whether concomitant exacerbated inflammation and autoimmunity caused by the deficiency of IL1R8 could recapitulate autoimmunity-associated lymphomagenesis. We thus monitored B-cell lymphoma development during the aging of IL1R8-deficient lpr m …
We herein investigated whether concomitant exacerbated inflammation and autoimmunity caused by the deficiency of IL1R8 could recapitu …
Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies.
Durandy A, Taubenheim N, Peron S, Fischer A. Durandy A, et al. Adv Immunol. 2007;94:275-306. doi: 10.1016/S0065-2776(06)94009-7. Adv Immunol. 2007. PMID: 17560278 Review.
Ig-CSR deficiency 2 is the consequence of uracil-N-glycosylase (UNG) deficiency. Because UNG, a molecule of the base excision repair machinery, removes uracils from DNA and AID deaminates cytosines into uracils, that observation indicates that the AID-UNG pat …
Ig-CSR deficiency 2 is the consequence of uracil-N-glycosylase (UNG) deficiency. Because UNG, a molecule of the base excision …
Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors.
Devarakonda CV, Kita D, Phoenix KN, Claffey KP. Devarakonda CV, et al. BMC Cancer. 2015 Sep 3;15:614. doi: 10.1186/s12885-015-1608-z. BMC Cancer. 2015. PMID: 26334999 Free PMC article.
In this paper we optimized our previous strategy by generating heavy chain antibodies (HCAbs) to overcome the deficiencies of single domain antibodies. Here we identified and characterized a heavy chain antibody (HCAb2) that targets cell surface …
In this paper we optimized our previous strategy by generating heavy chain antibodies (HCAbs) to overcome the deficiencies …
100 results