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Quoted phrase not found in phrase index: "Impaired ADP-induced platelet aggregation"
Page 1
The evolving knowledge on primary hemostasis in patients with cirrhosis: A comprehensive review.
Zanetto A, Campello E, Senzolo M, Simioni P. Zanetto A, et al. Hepatology. 2024 Feb 1;79(2):460-481. doi: 10.1097/HEP.0000000000000349. Epub 2023 Feb 27. Hepatology. 2024. PMID: 36825598 Review.
A more comprehensive and individualized risk assessment should combine hemostatic impairment, the severity of decompensation and systemic inflammation, and the presence of additional factors that may impair platelet function, such as acute kidney injury and b …
A more comprehensive and individualized risk assessment should combine hemostatic impairment, the severity of decompensation and syst …
The prognostic value of platelet aggregation in patients with sepsis.
Chen T, Yang H, Zhao Z, Wang H, Zhong S. Chen T, et al. Allergol Immunopathol (Madr). 2024 May 1;52(3):17-21. doi: 10.15586/aei.v52i3.1039. eCollection 2024. Allergol Immunopathol (Madr). 2024. PMID: 38721951
Patients with sepsis whose ADP-induced PAR was < 60% displayed significant impairment in platelet aggregation function, and had higher mortality rate. Monitoring ADP-induced PAR is crucial for management of sepsis....

Patients with sepsis whose ADP-induced PAR was < 60% displayed significant impairment in platelet aggregat

…
Glucocorticoids impair platelet thromboxane biosynthesis in community-acquired pneumonia.
Cangemi R, Carnevale R, Nocella C, Calvieri C, Cammisotto V, Novo M, Castellani V, D'Amico A, Zerbinati C, Stefanini L, Violi F; SIXTUS Study Group. Cangemi R, et al. Pharmacol Res. 2018 May;131:66-74. doi: 10.1016/j.phrs.2018.03.014. Epub 2018 Mar 22. Pharmacol Res. 2018. PMID: 29577968
In vitro, glucocorticoids-treated platelets showed a dose-dependent decrease of ADP-induced platelet aggregation, TxB(2) production, cPLA(2) phosphorylation and arachidonic acid release from the platelet membrane. ...Glucocorticoids reduce pl …
In vitro, glucocorticoids-treated platelets showed a dose-dependent decrease of ADP-induced platelet aggregation …
ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay.
Schäfer A, Weinberger S, Flierl U, Eigenthaler M, Störk S, Walter U, Ertl G, Bauersachs J. Schäfer A, et al. Thromb Haemost. 2008 Oct;100(4):618-25. Thromb Haemost. 2008. PMID: 18841284 Clinical Trial.
One hundred consecutive patients with coronary artery disease (CAD) on combined acetylsalicylic acid and clopidogrel treatment (75 mg/d) and 33 patients on aspirin only were screened for platelet ADP-induced signalling by conventional aggregometry, platele …
One hundred consecutive patients with coronary artery disease (CAD) on combined acetylsalicylic acid and clopidogrel treatment (75 mg/d) and …
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice.
Jiang LP, Ji JZ, Ge PX, Zhu T, Mi QY, Tai T, Li YF, Xie HG. Jiang LP, et al. Br J Pharmacol. 2022 Jan;179(1):46-64. doi: 10.1111/bph.15667. Epub 2021 Oct 29. Br J Pharmacol. 2022. PMID: 34415054 Free article.
Furthermore, high-fat diet-induced obese mice were used to reveal alterations in systemic exposure of clopidogrel thiol active metabolite H4, ADP-induced platelet activation and aggregation, the expression of genes involved in the metabolic activation …
Furthermore, high-fat diet-induced obese mice were used to reveal alterations in systemic exposure of clopidogrel thiol active metabolite H4 …
Antiplatelet resistance in outpatients with monitored adherence.
Walter PN, Tsakiris DA, Romanens M, Arnet I, Hersberger KE. Walter PN, et al. Platelets. 2014;25(7):532-8. doi: 10.3109/09537104.2013.845743. Epub 2013 Oct 31. Platelets. 2014. PMID: 24175592
We aimed at assessing factors to resistance when adherence to the antiplatelet drugs and all other oral solid drugs was controlled for. In a pilot study, we tested arachidonic acid and/or ADP-induced in vitro platelet aggregation of 82 outpatients with …
We aimed at assessing factors to resistance when adherence to the antiplatelet drugs and all other oral solid drugs was controlled for. In a …
Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.
Wand S, Schneider S, Meybohm P, Zacharowski K, Weber CF. Wand S, et al. Clin Lab. 2015;61(3-4):379-87. doi: 10.7754/clin.lab.2014.140931. Clin Lab. 2015. PMID: 25975006
Conventional laboratory coagulation analyses were routinely performed twice a day. Arachidonic acid- and ADP-induced platelet aggregations were defined as primary endpoints. ...Platelet aggregation in the ADPtest and TRAPtest remained unchanged …
Conventional laboratory coagulation analyses were routinely performed twice a day. Arachidonic acid- and ADP-induced platel …
Detection of clopidogrel resistance using ADP induced aggregometry with specific inhibitor PGE1.
Slavik L, Ulehlova J, Krcova V, Hlusi A, Indrakova J, Hutyra M, Galuszka J, Indrak K. Slavik L, et al. Clin Lab. 2014;60(9):1475-80. doi: 10.7754/clin.lab.2013.131004. Clin Lab. 2014. PMID: 25291943
It has a good clinical effect but increasing evidence shows high residual platelet aggregation activity in a number of patients. Laboratory methods only allow us to detect clopidogrel "non-responders" or "low responders". Recent methods are based on monitoring resid …
It has a good clinical effect but increasing evidence shows high residual platelet aggregation activity in a number of patient …
Impaired adenylate cyclase signaling in acute myocardial ischemia: Impact on effectiveness of P2Y(12) receptor antagonists.
Imam H, Nguyen TH, De Caterina R, Nooney VB, Chong CR, Horowitz JD, Chirkov YY. Imam H, et al. Thromb Res. 2019 Sep;181:92-98. doi: 10.1016/j.thromres.2019.07.016. Epub 2019 Jul 23. Thromb Res. 2019. PMID: 31376607
However, P2Y(12) blockade reverses this ADP-induced suppression of the platelet PGI(2)/AC signaling pathway. ...There was a strong correlation between extent of inhibition of platelet aggregation, whether by PGE(1) or Ilt, and the anti-aggregato …
However, P2Y(12) blockade reverses this ADP-induced suppression of the platelet PGI(2)/AC signaling pathway. ...There w …
Platelet function and its clinical significance in the myelodysplastic syndromes.
Zeidman A, Sokolover N, Fradin Z, Cohen A, Redlich O, Mittelman M. Zeidman A, et al. Hematol J. 2004;5(3):234-8. doi: 10.1038/sj.thj.6200364. Hematol J. 2004. PMID: 15167910
Only four MDS patients had BT longer than the normal 1-4 min range. Platelet aggregation (PA) was studied with epinephrine (Epi), ADP, arachidonic acid (AA), ristocetin and collagen. Overall, 16 (70%) patients had PA abnormality, 65% had impaired Epi-induced …
Only four MDS patients had BT longer than the normal 1-4 min range. Platelet aggregation (PA) was studied with epinephrine (Ep …
18 results