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45 results

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Page 1
Shear-dependent platelet aggregation size.
Chan CHH, Inoue M, Ki KK, Murashige T, Fraser JF, Simmonds MJ, Tansley GD, Watanabe N. Chan CHH, et al. Artif Organs. 2020 Dec;44(12):1286-1295. doi: 10.1111/aor.13783. Epub 2020 Aug 15. Artif Organs. 2020. PMID: 32735693 Free PMC article.
Nonsurgical bleeding is the most frequent complication of left ventricular assist device (LVAD) support. Supraphysiologic shear rates generated in LVAD causes impaired platelet aggregation, which increases the risk of bleeding. ...Therefore, this study invest …
Nonsurgical bleeding is the most frequent complication of left ventricular assist device (LVAD) support. Supraphysiologic shear rates genera …
Evaluation of abnormal bleeding in women.
Kouides PA. Kouides PA. Curr Hematol Rep. 2002 Sep;1(1):11-8. Curr Hematol Rep. 2002. PMID: 12901120 Review.
In addition, preliminary results suggest that another 20% to 30% of patients may have impaired platelet aggregation as another cause of menorrhagia. Disorders of fibrinolysis may be an additional underlying hemostatic disorder. ...Menorrhagia since menarche, …
In addition, preliminary results suggest that another 20% to 30% of patients may have impaired platelet aggregation as …
Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time.
Heubel-Moenen FCJI, Brouns SLN, Herfs L, Boerenkamp LS, Jooss NJ, Wetzels RJH, Verhezen PWM, Machiels P, Megy K, Downes K, Heemskerk JWM, Beckers EAM, Henskens YMC. Heubel-Moenen FCJI, et al. Br J Haematol. 2022 Mar;196(6):1388-1400. doi: 10.1111/bjh.18003. Epub 2022 Jan 10. Br J Haematol. 2022. PMID: 35001370 Free PMC article.
Patients referred for evaluation of bleeding symptoms occasionally have a prolonged platelet function analyser (PFA) closure time, without evidence for von Willebrand disease or impaired platelet aggregation. The aim of this study was to establish a shear-dep …
Patients referred for evaluation of bleeding symptoms occasionally have a prolonged platelet function analyser (PFA) closure time, without e …
The use of a low-flux hemo-dialyzer is associated with impaired platelet aggregation in patients undergoing chronic hemodialysis.
Chen CY, Liou HH, Chang MY, Wang HH, Lee YC, Ho LC, Lin TM, Hung SY. Chen CY, et al. Medicine (Baltimore). 2022 Oct 28;101(43):e31623. doi: 10.1097/MD.0000000000031623. Medicine (Baltimore). 2022. PMID: 36316899 Free PMC article.
In patients with chronic hemodialysis (HD), both abnormal thrombotic and bleeding events are commonly observed. Uremic platelet dysfunction is one of the important attributing factors. ...After adjusting confounding factors, only the low-flux dialyzer demonstrated an indep …
In patients with chronic hemodialysis (HD), both abnormal thrombotic and bleeding events are commonly observed. Uremic platelet dysfu …
Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury.
Matthay ZA, Fields AT, Nunez-Garcia B, Park JJ, Jones C, Leligdowicz A, Hendrickson CM, Callcut RA, Matthay MA, Kornblith LZ. Matthay ZA, et al. J Thromb Haemost. 2022 Sep;20(9):2109-2118. doi: 10.1111/jth.15763. Epub 2022 May 30. J Thromb Haemost. 2022. PMID: 35592998 Free PMC article.

RESULTS: In trauma patients, EPI and NE were associated with impaired platelet aggregation (both p < 0.05), and EPI was additionally associated with decreased viscoelastic clot strength, increased fibrinolysis, and mortality (all p < 0.05). In healthy d

…

RESULTS: In trauma patients, EPI and NE were associated with impaired platelet aggregation (both p < 0.05), and EPI

…
Role of Kv1.3 Channels in Platelet Functions and Thrombus Formation.
Fan C, Yang X, Wang WW, Wang J, Li W, Guo M, Huang S, Wang Z, Liu K. Fan C, et al. Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):2360-2375. doi: 10.1161/ATVBAHA.120.314278. Epub 2020 Aug 13. Arterioscler Thromb Vasc Biol. 2020. PMID: 32787516 Free article.
In vivo treatment with 6E12#15 alleviated thrombus formation in a mesenteric arteriole thrombosis mouse model and protected mice from collagen/epinephrine-induced pulmonary thromboembolism. Furthermore, we observed Kv1.3 regulated platelet functions by modulating Ca(2+) in …
In vivo treatment with 6E12#15 alleviated thrombus formation in a mesenteric arteriole thrombosis mouse model and protected mice from collag …
Venlafaxine-induced ecchymoses and impaired platelet aggregation.
Sarma A, Horne MK 3rd. Sarma A, et al. Eur J Haematol. 2006 Dec;77(6):533-7. doi: 10.1111/j.0902-4441.2006.t01-1-EJH2919.x. Epub 2006 Sep 15. Eur J Haematol. 2006. PMID: 16978240
However, our in vitro studies suggest that this hypothesis is inadequate to explain the observations completely....
However, our in vitro studies suggest that this hypothesis is inadequate to explain the observations completely....
Impaired platelet function and peripartum bleeding in women with Gaucher disease.
Simchen MJ, Oz R, Shenkman B, Zimran A, Elstein D, Kenet G. Simchen MJ, et al. Thromb Haemost. 2011 Mar;105(3):509-14. doi: 10.1160/TH10-07-0503. Epub 2011 Feb 8. Thromb Haemost. 2011. PMID: 21301776
The risk of bleeding during delivery may be increased in women with Gaucher disease. We aimed to evaluate potential predictors for peripartum haemorrhage (PPH) during childbirth in these patients, while focusing upon coagulation tests and platelet function assays. ...Fourt …
The risk of bleeding during delivery may be increased in women with Gaucher disease. We aimed to evaluate potential predictors for pe …
Characterization of GPVI- or GPVI-CD39-Coated Nanoparticles and Their Impact on In Vitro Thrombus Formation.
Nestele JA, Rohlfing AK, Dicenta V, Bild A, Eißler D, Emschermann F, Kremser M, Krutzke K, Schäffer TE, Borst O, Levi M, Korin N, Gawaz MP. Nestele JA, et al. Int J Mol Sci. 2021 Dec 21;23(1):11. doi: 10.3390/ijms23010011. Int J Mol Sci. 2021. PMID: 35008437 Free PMC article.
Light transmission aggregometry enabled analysis of platelet aggregation. Thrombus formation was observed through flow chamber experiments. NP-GPVI and NP-GPVI-CD39 displayed a characteristic surface coating pattern. Fluorescence properties were identical amongst all sampl …
Light transmission aggregometry enabled analysis of platelet aggregation. Thrombus formation was observed through flow chamber experi …
D-Dimer and Fibrin Degradation Products Impair Platelet Signaling: Plasma D-Dimer Is a Predictor and Mediator of Platelet Dysfunction During Trauma.
Verni CC, Davila A, Sims CA, Diamond SL. Verni CC, et al. J Appl Lab Med. 2020 Nov 1;5(6):1253-1264. doi: 10.1093/jalm/jfaa047. J Appl Lab Med. 2020. PMID: 32674119 Free PMC article.
RESULTS: For healthy platelets, maximal platelet dysfunction was observed when cross-linked soluble fibrin (no tPA) or cross-linked fibrin degradation products (FDPs) were generated in suspension before convulxin stimulation. Lack of fibrin polymerization (inhibited by Gly …
RESULTS: For healthy platelets, maximal platelet dysfunction was observed when cross-linked soluble fibrin (no tPA) or cross-linked f …
45 results