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Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time.
Heubel-Moenen FCJI, Brouns SLN, Herfs L, Boerenkamp LS, Jooss NJ, Wetzels RJH, Verhezen PWM, Machiels P, Megy K, Downes K, Heemskerk JWM, Beckers EAM, Henskens YMC. Heubel-Moenen FCJI, et al. Br J Haematol. 2022 Mar;196(6):1388-1400. doi: 10.1111/bjh.18003. Epub 2022 Jan 10. Br J Haematol. 2022. PMID: 35001370 Free PMC article.
Patients referred for evaluation of bleeding symptoms occasionally have a prolonged platelet function analyser (PFA) closure time, without evidence for von Willebrand disease or impaired platelet aggregation. The aim of this study was to establish a shear-dep …
Patients referred for evaluation of bleeding symptoms occasionally have a prolonged platelet function analyser (PFA) closure time, without e …
It's About Time: Transfusion effects on postinjury platelet aggregation over time.
Kornblith LZ, Decker A, Conroy AS, Hendrickson CM, Fields AT, Robles AJ, Callcut RA, Cohen MJ. Kornblith LZ, et al. J Trauma Acute Care Surg. 2019 Nov;87(5):1042-1051. doi: 10.1097/TA.0000000000002459. J Trauma Acute Care Surg. 2019. PMID: 31389915 Free PMC article.
Data suggest that following injury platelet transfusion may not correct impaired platelet aggregation, and impaired platelet aggregation may not predict the need for platelet transfusion. ...
Data suggest that following injury platelet transfusion may not correct impaired platelet aggregation, and impaired …
Mutations in RASGRP2 gene identified in patients misdiagnosed as Glanzmann thrombasthenia patients.
Rosenberg N, Dardik R, Hauschner H, Nakav S, Barel O, Luboshitz J, Yacobovich J, Tamary H, Kenet G. Rosenberg N, et al. Blood Cells Mol Dis. 2021 Jul;89:102560. doi: 10.1016/j.bcmd.2021.102560. Epub 2021 Mar 4. Blood Cells Mol Dis. 2021. PMID: 33711653
INTRODUCTION: Glanzmann thrombasthenia (GT) is a severe inherited platelet function disorder (IPFD), presenting with bleeding diathesis and impaired platelet aggregation, is caused by mutations in the genes ITGA2B or ITGB3. ...METHODS: During 2017-2019, 16 pa …
INTRODUCTION: Glanzmann thrombasthenia (GT) is a severe inherited platelet function disorder (IPFD), presenting with bleeding diathesis and …
Evaluation of abnormal bleeding in women.
Kouides PA. Kouides PA. Curr Hematol Rep. 2002 Sep;1(1):11-8. Curr Hematol Rep. 2002. PMID: 12901120 Review.
In addition, preliminary results suggest that another 20% to 30% of patients may have impaired platelet aggregation as another cause of menorrhagia. Disorders of fibrinolysis may be an additional underlying hemostatic disorder. ...
In addition, preliminary results suggest that another 20% to 30% of patients may have impaired platelet aggregation as …
A novel missense variant in the RASGRP2 gene in patients with moderate to severe bleeding disorder.
Alharby E, Bakhsh MA, Albalawi AM, Almutairi SO, Hashmi JA, Basit S. Alharby E, et al. Platelets. 2020 Jul 3;31(5):646-651. doi: 10.1080/09537104.2019.1663803. Epub 2019 Sep 5. Platelets. 2020. PMID: 32609603
It is characterized by deficient or dysfunctional CalDAG-GEFI protein. The distinctive feature of the disease is impaired platelet aggregation in response to multiple physiologic agonists. ...
It is characterized by deficient or dysfunctional CalDAG-GEFI protein. The distinctive feature of the disease is impaired platelet …
The possible value of platelet aggregation studies in patients with increased platelet number.
Fabris F, Randi M, Sbrojavacca R, Casonato A, Girolami A. Fabris F, et al. Blut. 1981 Nov;43(5):279-85. doi: 10.1007/BF00320951. Blut. 1981. PMID: 7326440
A relationship between increased platelet aggregation and the occurrence of thrombosis was demonstrated. Similarly, a correction between impaired platelet aggregation and bleeding was also present. These results emphasize the diagnostic value of platelet aggr …
A relationship between increased platelet aggregation and the occurrence of thrombosis was demonstrated. Similarly, a correction between …
Whole blood ristocetin-activated platelet impedance aggregometry (Multiplate) for the rapid detection of Von Willebrand disease.
Schmidt DE, Bruzelius M, Majeed A, Odeberg J, Holmström M, Ågren A. Schmidt DE, et al. Thromb Haemost. 2017 Jul 26;117(8):1528-1533. doi: 10.1160/TH17-02-0129. Epub 2017 Jul 6. Thromb Haemost. 2017. PMID: 28692107
The diagnostic properties of the test were described as sensitivity/specificity, positive and negative predictive value, and ROC area under the curve (AUC). Patients with VWD had impaired platelet aggregation by WB-RIPA. At a cut-off of 98 U, the test sensiti …
The diagnostic properties of the test were described as sensitivity/specificity, positive and negative predictive value, and ROC area under …
Misoprostol-associated platelet aggregation dysfunction and increased gastrointestinal blood loss.
Beales IL, Clemons M, Kong WM. Beales IL, et al. Eur J Gastroenterol Hepatol. 1997 Jan;9(1):91-2. doi: 10.1097/00042737-199701000-00021. Eur J Gastroenterol Hepatol. 1997. PMID: 9031907
Investigations showed prolonged bleeding time and severely impaired platelet aggregation in vitro. Withdrawal of misoprostol resulted in resolution of the prolonged bleeding time and improvement in the platelet dysfunction. ...
Investigations showed prolonged bleeding time and severely impaired platelet aggregation in vitro. Withdrawal of misopr …
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.
Dwyer KM, Robson SC, Nandurkar HH, Campbell DJ, Gock H, Murray-Segal LJ, Fisicaro N, Mysore TB, Kaczmarek E, Cowan PJ, d'Apice AJ. Dwyer KM, et al. J Clin Invest. 2004 May;113(10):1440-6. doi: 10.1172/JCI19560. J Clin Invest. 2004. PMID: 15146241 Free PMC article.
Importantly, these mice displayed no overt spontaneous bleeding tendency under normal circumstances. The hCD39 transgenic mice did, however, exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. ...
Importantly, these mice displayed no overt spontaneous bleeding tendency under normal circumstances. The hCD39 transgenic mice did, however, …
15 results