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Quoted phrase not found in phrase index: "Increased intramyocellular lipid droplets"
Page 1
Intramyocellular lipid content in human skeletal muscle.
Schrauwen-Hinderling VB, Hesselink MK, Schrauwen P, Kooi ME. Schrauwen-Hinderling VB, et al. Obesity (Silver Spring). 2006 Mar;14(3):357-67. doi: 10.1038/oby.2006.47. Obesity (Silver Spring). 2006. PMID: 16648604 Free article. Review.
Fat can be stored not only in adipose tissue but also in other tissues such as skeletal muscle. Fat droplets accumulated in skeletal muscle [intramyocellular lipids (IMCLs)] can be quantified by different methods, all with advantages and drawbacks. ...Together, this …
Fat can be stored not only in adipose tissue but also in other tissues such as skeletal muscle. Fat droplets accumulated in skeletal …
Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity.
Moro C, Bajpeyi S, Smith SR. Moro C, et al. Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E203-13. doi: 10.1152/ajpendo.00624.2007. Epub 2007 Nov 14. Am J Physiol Endocrinol Metab. 2008. PMID: 18003718 Free article. Review.
Increased intramyocellular triglyceride (IMTG) content is found in both insulin-sensitive endurance-trained subjects and insulin-resistant obese/type 2 diabetic subjects. ...Thus the co-localization of intermyofibrillar lipid droplets and mitochondria …
Increased intramyocellular triglyceride (IMTG) content is found in both insulin-sensitive endurance-trained subjects and insul …
Intramyocellular lipids and insulin resistance.
Machann J, Häring H, Schick F, Stumvoll M. Machann J, et al. Diabetes Obes Metab. 2004 Jul;6(4):239-48. doi: 10.1111/j.1462-8902.2004.00339.x. Diabetes Obes Metab. 2004. PMID: 15171747 Review.
This review summarizes history, measurement techniques and interpretation of muscle lipid data. Problems in biopsies with the separation of those metabolically active lipid droplets in the cytoplasm of myocytes from further lipids in adipocytes are discussed …
This review summarizes history, measurement techniques and interpretation of muscle lipid data. Problems in biopsies with the separat …
Mitochondria, glycogen, and lipid droplets in skeletal muscle during testosterone treatment and strength training: a randomized, double-blinded, placebo-controlled trial.
Jensen RC, Christensen LL, Nielsen J, Schrøder HD, Kvorning T, Gejl K, Højlund K, Glintborg D, Andersen M. Jensen RC, et al. Andrology. 2018 Jul;6(4):547-555. doi: 10.1111/andr.12492. Epub 2018 Apr 15. Andrology. 2018. PMID: 29656500 Free article. Clinical Trial.
Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. ...Six-month ST or combined three-month ST+TRT did not change intramyocellular mitochondria, glycogen, and LD fractions compared to …
Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle …
Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?
Gemmink A, Daemen S, Brouwers B, Huntjens PR, Schaart G, Moonen-Kornips E, Jörgensen J, Hoeks J, Schrauwen P, Hesselink MKC. Gemmink A, et al. J Physiol. 2018 Mar 1;596(5):857-868. doi: 10.1113/JP275182. Epub 2017 Nov 23. J Physiol. 2018. PMID: 29110300 Free PMC article.
KEY POINTS: Intramyocellular lipid storage is negatively associated with insulin sensitivity. ...In the present study, we tested whether the fraction of PLIN5-coated lipid droplets (LDs) is a determinant of skeletal muscle insulin sensitivity and contr …
KEY POINTS: Intramyocellular lipid storage is negatively associated with insulin sensitivity. ...In the present study, we test …
Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans.
Gemmink A, Bosma M, Kuijpers HJ, Hoeks J, Schaart G, van Zandvoort MA, Schrauwen P, Hesselink MK. Gemmink A, et al. Diabetologia. 2016 May;59(5):1040-8. doi: 10.1007/s00125-016-3865-z. Epub 2016 Feb 10. Diabetologia. 2016. PMID: 26864436 Free PMC article. Clinical Trial.
AIMS/HYPOTHESIS: In contrast to insulin-resistant individuals, insulin-sensitive athletes possess high intramyocellular lipid content (IMCL), good mitochondrial function and high perilipin 5 (PLIN5) levels, suggesting a role for PLIN5 in benign IMCL storage. ...METH …
AIMS/HYPOTHESIS: In contrast to insulin-resistant individuals, insulin-sensitive athletes possess high intramyocellular lipid …
Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians.
Gemmink A, Bakker LE, Guigas B, Kornips E, Schaart G, Meinders AE, Jazet IM, Hesselink MK. Gemmink A, et al. Sci Rep. 2017 Feb 14;7:42393. doi: 10.1038/srep42393. Sci Rep. 2017. PMID: 28195217 Free PMC article. Clinical Trial.
Triglyceride extractions and Western Blots for lipid droplet and mitochondrial proteins were performed. Intramyocellular lipid content and HFHC-diet response were similar between ethnicities (group effect: P = 0.094; diet effect: +~30%, P = 0.044). ...These d …
Triglyceride extractions and Western Blots for lipid droplet and mitochondrial proteins were performed. Intramyocellular li …
Intramyocellular Lipid Droplet Size Rather Than Total Lipid Content is Related to Insulin Sensitivity After 8 Weeks of Overfeeding.
Covington JD, Johannsen DL, Coen PM, Burk DH, Obanda DN, Ebenezer PJ, Tam CS, Goodpaster BH, Ravussin E, Bajpeyi S. Covington JD, et al. Obesity (Silver Spring). 2017 Dec;25(12):2079-2087. doi: 10.1002/oby.21980. Epub 2017 Oct 25. Obesity (Silver Spring). 2017. PMID: 29071793 Free PMC article.
Measures of IMCL, whole-body fat oxidation from a 24-hour metabolic chamber, muscle protein extracts, and muscle ceramide measures were obtained before and after the intervention. RESULTS: Eight weeks of overfeeding did not increase overall IMCL. The content of smaller …
Measures of IMCL, whole-body fat oxidation from a 24-hour metabolic chamber, muscle protein extracts, and muscle ceramide measures were obta …
Effects of weight loss and physical activity on muscle lipid content and droplet size.
He J, Goodpaster BH, Kelley DE. He J, et al. Obes Res. 2004 May;12(5):761-9. doi: 10.1038/oby.2004.92. Obes Res. 2004. PMID: 15166296 Free article.

IMCL did not significantly change (p = 0.36). However, the size of lipid droplets decreased after WL + Ex (p < 0.01), and this decrease in lipid droplet size correlated with increased IS (p < 0.01) and the amount of physical activity (p < 0.05

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IMCL did not significantly change (p = 0.36). However, the size of lipid droplets decreased after WL + Ex (p < 0.01), and t

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Resveratrol-induced remodelling of myocellular lipid stores: A study in metabolically compromised humans.
van Polanen N, Zacharewicz E, de Ligt M, Timmers S, Moonen-Kornips E, Schaart G, Hoeks J, Schrauwen P, Hesselink MKC. van Polanen N, et al. Physiol Rep. 2021 Jan;9(2):e14692. doi: 10.14814/phy2.14692. Physiol Rep. 2021. PMID: 33476086 Free PMC article.
In non-athletes, insulin sensitivity correlates negatively with intramyocellular lipid (IMCL) content. In athletes, however, a pattern of benign IMCL storage exists, which is characterized by lipid storage in type I muscle fibres, in small and numerous lip …
In non-athletes, insulin sensitivity correlates negatively with intramyocellular lipid (IMCL) content. In athletes, however, a …
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