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Quoted phrase not found in phrase index: "Increased circulating interleukin 21 concentration"
Page 1
Measurement of IL-21 in human serum and plasma using ultrasensitive MSD S-PLEX® and Quanterix SiMoA methodologies.
Poorbaugh J, Samanta T, Bright SW, Sissons SE, Chang CY, Oberoi P, MacDonald AJ, Martin AP, Cox KL, Benschop RJ. Poorbaugh J, et al. J Immunol Methods. 2019 Mar;466:9-16. doi: 10.1016/j.jim.2018.12.005. Epub 2018 Dec 24. J Immunol Methods. 2019. PMID: 30590020
IL-21 is a pleiotropic cytokine that plays a key role in modulating inflammatory responses, including the promotion of autoimmune diseases. Several groups have quantitated circulating levels of IL-21 in plasma and serum samples using various commercial ELISAs. ...Assays de …
IL-21 is a pleiotropic cytokine that plays a key role in modulating inflammatory responses, including the promotion of autoimmune diseases. …
An association of circulating Tregs and Th17 cells producing IL-21 and IL-22 with the ROMA in ovarian cancer patients.
Winkler I, Woś J, Karczmarczyk A, Miotła P, Gogacz M, Skorupska K, Rechberger T, Tabarkiewicz J, Wolińska E, Skrzypczak M. Winkler I, et al. Cytokine. 2020 Oct;134:155194. doi: 10.1016/j.cyto.2020.155194. Epub 2020 Jul 21. Cytokine. 2020. PMID: 32707423
The percentage of Tregs and Th17 releasing IL-21 or IL-22 cells from both peripheral blood and tumor tissue was measured by flow cytometry. No differences in demographic parameters like body mass index, age, or gravidity were observed among the studied groups. Howev …
The percentage of Tregs and Th17 releasing IL-21 or IL-22 cells from both peripheral blood and tumor tissue was measured by flow cyto …
Serum CXCL13, BAFF, IL-21 and IL-22 levels are related to disease activity and lymphocyte profile in primary Sjögren's syndrome.
Loureiro-Amigo J, Franco-Jarava C, Perurena-Prieto J, Palacio C, Martínez-Valle F, Soláns-Laqué R. Loureiro-Amigo J, et al. Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):131-139. doi: 10.55563/clinexprheumatol/fp741f. Epub 2021 Dec 15. Clin Exp Rheumatol. 2021. PMID: 34919042 Free article.
OBJECTIVES: To investigate the utility of serum BAFF, IL-17, IL-18, IL-21, IL-22, CXCL13, TNF-R2 and PD-L2 as biomarkers of disease activity in primary Sjogren's syndrome (pSS), their relationship with lymphocyte subpopulations and their accuracy to discriminate pSS from Sicca sy …
OBJECTIVES: To investigate the utility of serum BAFF, IL-17, IL-18, IL-21, IL-22, CXCL13, TNF-R2 and PD-L2 as biomarkers of disease activity …
Circulating CD4(+) FoxP3(-) CXCR5(-) CXCR3(+) PD-1(hi) cells are elevated in active rheumatoid arthritis and reflect the severity of the disease.
Zhao L, Li Z, Zeng X, Xia C, Xu L, Xu Q, Song Y, Liu C. Zhao L, et al. Int J Rheum Dis. 2021 Aug;24(8):1032-1039. doi: 10.1111/1756-185X.14170. Epub 2021 Jul 6. Int J Rheum Dis. 2021. PMID: 34227243
RESULTS: The levels of CD4(+) FoxP3(-) CXCR5(-) CXCR3(+) PD-1(hi) cells in the peripheral blood of patients with active RA were significantly increased compared with healthy controls. ...CONCLUSION: Circulating CD4(+) FoxP3(-) CXCR5(-) CXCR3(+) PD-1(hi) cells …
RESULTS: The levels of CD4(+) FoxP3(-) CXCR5(-) CXCR3(+) PD-1(hi) cells in the peripheral blood of patients with active RA were signi …
T follicular helper cells in patients with acute schistosomiasis.
Zhang Y, Wang Y, Jiang Y, Pan W, Liu H, Yin J, Shen Y, Cao J. Zhang Y, et al. Parasit Vectors. 2016 Jun 6;9(1):321. doi: 10.1186/s13071-016-1602-6. Parasit Vectors. 2016. PMID: 27266984 Free PMC article.
BACKGROUND: The role of T follicular helper (Tfh) cells in schistosome infection is not fully defined. In a previous study, a higher frequency of circulating PD-1(+)CXCR5(+)CD4(+) Tfh cells was observed in patients with chronic schistosomiasis relative to healthy co …
BACKGROUND: The role of T follicular helper (Tfh) cells in schistosome infection is not fully defined. In a previous study, a higher frequen …
Long-Term Suppression of Circulating Proinflammatory Cytokines in Multiple Sclerosis Patients Following Autologous Haematopoietic Stem Cell Transplantation.
Hendrawan K, Khoo MLM, Visweswaran M, Massey JC, Withers B, Sutton I, Ma DDF, Moore JJ. Hendrawan K, et al. Front Immunol. 2022 Jan 19;12:782935. doi: 10.3389/fimmu.2021.782935. eCollection 2021. Front Immunol. 2022. PMID: 35126353 Free PMC article. Clinical Trial.
The immunological mechanisms underlying remission in MS patients following AHSCT likely involve an anti-inflammatory shift in the milieu of circulating cytokines. We hypothesised that immunological tolerance in MS patients post-AHSCT is reflected by an increase in a …
The immunological mechanisms underlying remission in MS patients following AHSCT likely involve an anti-inflammatory shift in the milieu of …
Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus.
Feng X, Wang D, Chen J, Lu L, Hua B, Li X, Tsao BP, Sun L. Feng X, et al. PLoS One. 2012;7(12):e51982. doi: 10.1371/journal.pone.0051982. Epub 2012 Dec 17. PLoS One. 2012. PMID: 23284839 Free PMC article.
METHODS: Peripheral blood mononuclear cells (PBMCs) from 42 SLE patients and 22 matched healthy subjects were collected to assess proportions of circulating CXCR5(+)PD1(+)/CD4(+) T cells (Tfh), CD4(+)CCR6(+) T cells (Th17-like) and CD19(+)CD138(+) plasma cells by fl …
METHODS: Peripheral blood mononuclear cells (PBMCs) from 42 SLE patients and 22 matched healthy subjects were collected to assess pro …
Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity.
Wong CK, Wong PT, Tam LS, Li EK, Chen DP, Lam CW. Wong CK, et al. J Clin Immunol. 2010 Jan;30(1):45-52. doi: 10.1007/s10875-009-9325-5. Epub 2009 Sep 23. J Clin Immunol. 2010. PMID: 19774453

RESULTS AND DISCUSSION: Plasma CXCL13, BAFF, and IL-21 concentrations were significantly higher in SLE patients than NC group (all p < 0.0001). Increase in CXCL13 concentration correlated positively and significantly with SLEDAI score in SLE patient

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RESULTS AND DISCUSSION: Plasma CXCL13, BAFF, and IL-21 concentrations were significantly higher in SLE patients than NC group (all p …
Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis.
Ma J, Zhu C, Ma B, Tian J, Baidoo SE, Mao C, Wu W, Chen J, Tong J, Yang M, Jiao Z, Xu H, Lu L, Wang S. Ma J, et al. Clin Dev Immunol. 2012;2012:827480. doi: 10.1155/2012/827480. Epub 2012 May 10. Clin Dev Immunol. 2012. PMID: 22649468 Free PMC article.
Firstly, we found that the frequency of CD4(+)CXCR5(+)ICOS(high) Tfh cells was increased significantly in the peripheral blood of RA patients, compared with that in healthy controls. ...Furthermore, expression of Bcl-6 mRNA and plasma IL-21 concentrations in …
Firstly, we found that the frequency of CD4(+)CXCR5(+)ICOS(high) Tfh cells was increased significantly in the peripheral blood …
Circulating CD4(+)CXCR5(+) T Cells Exacerbate B Cell Antibody Production in Crohn's Disease Through IL-21 Secretion.
Wang Z, Ding L, Wang Z, Wang J, Zhu N, Diao Y, Demmy TA, Haitsma JM, Lech-Maranda EE, Bangia NN, Czuczman MA, Qian X, Kovacs KL. Wang Z, et al. Immunol Invest. 2015;44(7):665-77. doi: 10.3109/08820139.2015.1074246. Immunol Invest. 2015. Retraction in: Immunol Invest. 2016 Jul;45(5):471. doi: 10.1080/08820139.2016.1190256. PMID: 26436852 Retracted.
Interleukin-21 (IL-21) upregulation was observed in Crohn's disease (CD) patients and was shown to contribute to ongoing mucosal inflammation in CD patients through stabilizing Th1 cell differentiation and IFN-gamma production. ...ICOS and PD-1 expressions we …
Interleukin-21 (IL-21) upregulation was observed in Crohn's disease (CD) patients and was shown to contribute to ongoin …
14 results