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Quoted phrase not found in phrase index: "Increased hepatocellular lipid droplets"
Page 1
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
Ceni E, Mello T, Galli A. Ceni E, et al. World J Gastroenterol. 2014 Dec 21;20(47):17756-72. doi: 10.3748/wjg.v20.i47.17756. World J Gastroenterol. 2014. PMID: 25548474 Free PMC article. Review.
Ethanol oxidative metabolism influences intracellular signaling pathways and deranges the transcriptional control of several genes, leading to fat accumulation, fibrogenesis and activation of innate and adaptive immunity. Acetaldehyde is known to be toxic to the liver and alters …
Ethanol oxidative metabolism influences intracellular signaling pathways and deranges the transcriptional control of several genes, leading …
Insulin resistance and reduced metabolic flexibility: cause or consequence of NAFLD?
Gastaldelli A. Gastaldelli A. Clin Sci (Lond). 2017 Nov 6;131(22):2701-2704. doi: 10.1042/CS20170987. Print 2017 Nov 15. Clin Sci (Lond). 2017. PMID: 29109303
Recent studies have shown that there are two phenotypes of NAFLD, 'genetic' vs 'metabolic' NAFLD. The former patients are more at risk of hepatocellular carcinoma and chronic liver disease the latter are more IR and at increased risk of type 2 diabetes (T2D). ...T2D …
Recent studies have shown that there are two phenotypes of NAFLD, 'genetic' vs 'metabolic' NAFLD. The former patients are more at risk of …
AMPK/mTOR pathway significance in healthy liver and non-alcoholic fatty liver disease and its progression.
Marcondes-de-Castro IA, Reis-Barbosa PH, Marinho TS, Aguila MB, Mandarim-de-Lacerda CA. Marcondes-de-Castro IA, et al. J Gastroenterol Hepatol. 2023 Nov;38(11):1868-1876. doi: 10.1111/jgh.16272. Epub 2023 Jul 12. J Gastroenterol Hepatol. 2023. PMID: 37438882 Review.
The kinase complex, consisting of Unc-51-like autophagy-activating kinase 1 or 2 (ULK1, ULK2) by stimulating autophagy, and eliminating fat droplets in NAFLD, is regulated by mTORC1 and negatively regulated by AMPK that suppresses liver lipogenesis and increases fat …
The kinase complex, consisting of Unc-51-like autophagy-activating kinase 1 or 2 (ULK1, ULK2) by stimulating autophagy, and eliminating fat …
Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases.
Kim YS, Kim SG. Kim YS, et al. Clin Mol Hepatol. 2020 Oct;26(4):715-727. doi: 10.3350/cmh.2020.0173. Epub 2020 Sep 22. Clin Mol Hepatol. 2020. PMID: 32951410 Free PMC article. Review.
Alcoholic and non-alcoholic liver diseases begin from an imbalance in lipid metabolism in hepatocytes as the earliest response. Both liver diseases share common disease features and stages (i.e., steatosis, hepatitis, cirrhosis, and hepatocellular carcinoma). ...Aut …
Alcoholic and non-alcoholic liver diseases begin from an imbalance in lipid metabolism in hepatocytes as the earliest response. Both …
Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis.
Carlsson B, Lindén D, Brolén G, Liljeblad M, Bjursell M, Romeo S, Loomba R. Carlsson B, et al. Aliment Pharmacol Ther. 2020 Jun;51(12):1305-1320. doi: 10.1111/apt.15738. Epub 2020 May 7. Aliment Pharmacol Ther. 2020. PMID: 32383295 Free PMC article. Review.
These genetic variants are common and have moderate-to-large effect sizes for development of NAFLD, NASH and hepatocellular carcinoma (HCC). The genes play roles in lipid remodelling in lipid droplets, hepatic very low-density lipoprotein (VLDL) secret …
These genetic variants are common and have moderate-to-large effect sizes for development of NAFLD, NASH and hepatocellular carcinoma …
Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.
Ndiaye H, Liu JY, Hall A, Minogue S, Morgan MY, Waugh MG. Ndiaye H, et al. Biosci Rep. 2020 Apr 30;40(4):BSR20200219. doi: 10.1042/BSR20200219. Biosci Rep. 2020. PMID: 32286604 Free PMC article.
Increased ACSL3 expression distinguished HCC from CCA with a sensitivity of 87.2% and a specificity of 75%. ...These enzymes had partially overlapping intracellular distributions, ACSL4 localised to the plasma membrane and both isoforms associated with lipid drop …
Increased ACSL3 expression distinguished HCC from CCA with a sensitivity of 87.2% and a specificity of 75%. ...These enzymes had part …
Ketocyanine-Based Fluorescent Probe Revealing the Polarity Heterogeneity of Lipid Droplets and Enabling Accurate Diagnosis of Hepatocellular Carcinoma.
He D, Yan M, Sun Q, Zhang M, Xia Y, Sun Y, Li Z. He D, et al. Adv Healthc Mater. 2024 Mar;13(7):e2303212. doi: 10.1002/adhm.202303212. Epub 2024 Feb 5. Adv Healthc Mater. 2024. PMID: 38241604
Hepatocellular carcinoma (HCC) has gradually become a pronoun for terrifying death owing to its high mortality rate. With the progression of HCC, lipid droplets (LDs) in HCC cells exhibit specific variations such as increased LDs number and decreased p …
Hepatocellular carcinoma (HCC) has gradually become a pronoun for terrifying death owing to its high mortality rate. With the progres …
Familial non-alcoholic steatohepatitis leading to hepatocellular carcinoma.
Neuman MG Prof, Cohen LB Dr, Malnick S Dr. Neuman MG Prof, et al. Chem Biol Interact. 2020 May 25;323:109054. doi: 10.1016/j.cbi.2020.109054. Epub 2020 Mar 23. Chem Biol Interact. 2020. PMID: 32217109
The trichrome stain revealed portal to portal bridging fibrosis. In one family, there was a three-fold increase in relative numbers of perisinusoidal macrophages in the older sister with NASH compared to livers of the younger siblings. ...
The trichrome stain revealed portal to portal bridging fibrosis. In one family, there was a three-fold increase in relative numbers o …
Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans.
Amrutkar M, Kern M, Nuñez-Durán E, Ståhlman M, Cansby E, Chursa U, Stenfeldt E, Borén J, Blüher M, Mahlapuu M. Amrutkar M, et al. Diabetologia. 2016 Feb;59(2):341-53. doi: 10.1007/s00125-015-3801-7. Epub 2015 Nov 9. Diabetologia. 2016. PMID: 26553096
RESULTS: Overexpression of STK25 in IHH and HepG2 cells enhanced lipid deposition by suppressing beta-oxidation and triacylglycerol (TAG) secretion, while increasing lipid synthesis. ...CONCLUSIONS/INTERPRETATION: Our data suggest that STK25 regulates lipi …
RESULTS: Overexpression of STK25 in IHH and HepG2 cells enhanced lipid deposition by suppressing beta-oxidation and triacylglycerol ( …
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, Manchem VP, Brown JM, Samuel VT, Shulman GI. Cantley JL, et al. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1869-74. doi: 10.1073/pnas.1219456110. Epub 2013 Jan 9. Proc Natl Acad Sci U S A. 2013. PMID: 23302688 Free PMC article.
CGI-58 knockdown in mice using antisense oligonucleotide (ASO) treatment also leads to severe hepatic steatosis as well as increased hepatocellular diacylglycerol (DAG) content, a well-documented trigger of insulin resistance. ...However, DAG increased in …
CGI-58 knockdown in mice using antisense oligonucleotide (ASO) treatment also leads to severe hepatic steatosis as well as increased …
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