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Quoted phrase not found in phrase index: "Increased phosphoribosylpyrophosphate synthetase level"
Page 1
Mutant feedback-resistant phosphoribosylpyrophosphate synthetase associated with purine overproduction and gout. Phosphoribosylpyrophosphate and purine metabolism in cultured fibroblasts.
J Clin Invest. 1975 Nov;56(5):1093-9. doi: 10.1172/JCI108183.
J Clin Invest. 1975.
PMID: 171280
Free PMC article.
We have reported previously two siblings with gout and uric acid lithiasis associated with excessive purine production. In the erythrocytes of these patients, phosphoribosylpyrophosphate (PRPP) synthetase exhibited resistance to feedback-inhibition by normal cell co …
We have reported previously two siblings with gout and uric acid lithiasis associated with excessive purine production. In the erythrocytes …
Regulation of purine synthesis de novo in human fibroblasts by purine nucleotides and phosphoribosylpyrophosphate.
Becker MA, Kim M.
Becker MA, et al.
J Biol Chem. 1987 Oct 25;262(30):14531-7.
J Biol Chem. 1987.
PMID: 2444588
Free article.
Previous studies of purine nucleotide synthesis de novo have suggested that major regulation of the rate of the pathway is affected at either the phosphoribosylpyrophosphate (PP-Rib-P) synthetase reaction or the amidophosphoribosyltransferase (amido PRT) reaction, o …
Previous studies of purine nucleotide synthesis de novo have suggested that major regulation of the rate of the pathway is affected at eithe …
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Cell-Cycle-Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis.
Jing X, Wang XJ, Zhang T, Zhu W, Fang Y, Wu H, Liu X, Ma D, Ji X, Jiang Y, Liu K, Chen X, Shi Y, Zhang Y, Shi M, Qiu W, Zhao R.
Jing X, et al.
Cancer Res. 2019 Sep 15;79(18):4650-4664. doi: 10.1158/0008-5472.CAN-18-2486. Epub 2019 Jun 28.
Cancer Res. 2019.
PMID: 31253668
Nucleotide supply is essential for DNA replication in proliferating cells, including cancer cells. Ribose-phosphate diphosphokinase 1 (PRPS1) is a key enzyme to produce the consensus precursor of nucleotide synthesis. ...In conclusion, compared with upregulation of …
Nucleotide supply is essential for DNA replication in proliferating cells, including cancer cells. Ribose-phosphate diphosphok …
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Inhibition of phosphoribosylpyrophosphate synthesis by purine nucleosides in human erythrocytes.
Planet G, Fox IH.
Planet G, et al.
J Biol Chem. 1976 Oct 10;251(19):5839-44.
J Biol Chem. 1976.
PMID: 972142
Free article.
The effects of purine nucleosides on 5-phosphoribosylpyrophosphate (PP-ribose-P) synthesis were investigated in human erythrocytes in vitro. Previous observations have shown an increase of PP-ribose-P formation with nucleoside when inorganic phosphate (Pi) exceeded …
The effects of purine nucleosides on 5-phosphoribosylpyrophosphate (PP-ribose-P) synthesis were investigated in human erythrocytes in …
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