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Quoted phrase not found in phrase index: "Increased phosphoribosylpyrophosphate synthetase level"
Page 1
Overexpression of the normal phosphoribosylpyrophosphate synthetase 1 isoform underlies catalytic superactivity of human phosphoribosylpyrophosphate synthetase.
Becker MA, Taylor W, Smith PR, Ahmed M. Becker MA, et al. J Biol Chem. 1996 Aug 16;271(33):19894-9. doi: 10.1074/jbc.271.33.19894. J Biol Chem. 1996. PMID: 8702702 Free article.
To define the enzymatic and genetic basis of X-linked phosphoribosylpyrophosphate synthetase (PRS) catalytic superactivity, we measured concentrations of X-linked PRS1 and PRS2 isoforms in cultured fibroblasts and lymphoblasts by immunoblotting after separation by p …
To define the enzymatic and genetic basis of X-linked phosphoribosylpyrophosphate synthetase (PRS) catalytic superactivity, we …
MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells.
Qiu Z, Guo W, Wang Q, Chen Z, Huang S, Zhao F, Yao M, Zhao Y, He X. Qiu Z, et al. Gastroenterology. 2015 Nov;149(6):1587-1598.e11. doi: 10.1053/j.gastro.2015.07.050. Epub 2015 Aug 3. Gastroenterology. 2015. PMID: 26248089
Compared with normal colorectal tissues, levels of miR124 were reduced significantly in CRC tissues from patients, whereas levels of PRPS1 and RPIA increased, which was associated with reduced patient survival times. ...Expression of miR124 and its targets correlate with s …
Compared with normal colorectal tissues, levels of miR124 were reduced significantly in CRC tissues from patients, whereas levels of PRPS1 a …
Cell-Cycle-Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis.
Jing X, Wang XJ, Zhang T, Zhu W, Fang Y, Wu H, Liu X, Ma D, Ji X, Jiang Y, Liu K, Chen X, Shi Y, Zhang Y, Shi M, Qiu W, Zhao R. Jing X, et al. Cancer Res. 2019 Sep 15;79(18):4650-4664. doi: 10.1158/0008-5472.CAN-18-2486. Epub 2019 Jun 28. Cancer Res. 2019. PMID: 31253668
Nucleotide supply is essential for DNA replication in proliferating cells, including cancer cells. Ribose-phosphate diphosphokinase 1 (PRPS1) is a key enzyme to produce the consensus precursor of nucleotide synthesis. ...In conclusion, compared with upregulation of …
Nucleotide supply is essential for DNA replication in proliferating cells, including cancer cells. Ribose-phosphate diphosphok …
Detection of potential enzyme targets by metabolic modelling and optimization: application to a simple enzymopathy.
Vera J, Curto R, Cascante M, Torres NV. Vera J, et al. Bioinformatics. 2007 Sep 1;23(17):2281-9. doi: 10.1093/bioinformatics/btm326. Epub 2007 Jun 22. Bioinformatics. 2007. PMID: 17586544
The method involves four steps: (i) collection of the necessary information about the metabolic system and disease; (ii) translation of the information into mathematical terms; (iii) computation of the optimization programs prioritizing the solutions that propose the inhibition o …
The method involves four steps: (i) collection of the necessary information about the metabolic system and disease; (ii) translation of the …