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119 results

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Quoted phrase not found in phrase index: "Increased proportion of HLA DR+ T cells"
Page 1
Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning.
Wang J, Kang Z, Liu Y, Li Z, Liu Y, Liu J. Wang J, et al. Front Immunol. 2022 Sep 23;13:956078. doi: 10.3389/fimmu.2022.956078. eCollection 2022. Front Immunol. 2022. PMID: 36211422 Free PMC article.
Important cell types and hub genes were screened using machine learning methods including least absolute shrinkage and selection operator (LASSO) regression and random forest. Single-cell RNA sequencing and clinical samples were further used to validate critical cel …
Important cell types and hub genes were screened using machine learning methods including least absolute shrinkage and selection operator (L …
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma.
Verkleij CPM, Broekmans MEC, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, Kaiser M, Morgan G, Axel A, Boominathan R, Sendecki J, Wong A, Verona RI, Sonneveld P, Zweegman S, Adams HC, Mutis T, van de Donk NWCJ. Verkleij CPM, et al. Blood Adv. 2021 Apr 27;5(8):2196-2215. doi: 10.1182/bloodadvances.2020003805. Blood Adv. 2021. PMID: 33890981 Free PMC article.
The novel GPRC5D-targeting T-cell redirecting bispecific antibody, talquetamab, effectively kills GPRC5D+ MM cell lines in the presence of T cells from both healthy donors or heavily pretreated MM patients. ...High levels of GPRC5D and high effector:target ratio wer …
The novel GPRC5D-targeting T-cell redirecting bispecific antibody, talquetamab, effectively kills GPRC5D+ MM cell lines in the presence of …
Antiretroviral Therapy Reduces T-cell Activation and Immune Exhaustion Markers in Human Immunodeficiency Virus Controllers.
Li JZ, Segal FP, Bosch RJ, Lalama CM, Roberts-Toler C, Delagreverie H, Getz R, Garcia-Broncano P, Kinslow J, Tressler R, Van Dam CN, Keefer M, Carrington M, Lichterfeld M, Kuritzkes D, Yu XG, Landay A, Sax PE; AIDS Clinical Trials Group Study A5308 Team. Li JZ, et al. Clin Infect Dis. 2020 Apr 10;70(8):1636-1642. doi: 10.1093/cid/ciz442. Clin Infect Dis. 2020. PMID: 31131858 Free PMC article. Clinical Trial.
METHODS: A5308 was a prospective, open-label study of rilpivirine/emtricitabine/tenofovir disoproxil fumarate in ART-naive HIV controllers (N = 35), defined as having HIV RNA <500 copies/mL for 12 months. The primary outcome measured change in %CD38+HLA-DR+ CD8+ …
METHODS: A5308 was a prospective, open-label study of rilpivirine/emtricitabine/tenofovir disoproxil fumarate in ART-naive HIV controllers ( …
The pattern and magnitude of T cell subsets reconstitution during ten years of ART with viral suppression in HIV-infected patients.
Lu L, Li X, Liu X, Qiu Z, Han Y, Song X, Li Y, Li X, Cao W, Lv W, Dou Z, Li T. Lu L, et al. Aging (Albany NY). 2022 Dec 9;14(23):9647-9667. doi: 10.18632/aging.204416. Epub 2022 Dec 9. Aging (Albany NY). 2022. PMID: 36490352 Free PMC article.
Naive and memory CD4+T cells'reconstitution occurred in the sixth and eighth years of ART but no significant change thereafter. ...CONCLUSIONS: Immune restoration was dependent on the capacity of immune system during the first 2-3 year of ART. But the significant ch …
Naive and memory CD4+T cells'reconstitution occurred in the sixth and eighth years of ART but no significant change thereafter …
Dynamic changes of the proportion of HLA-DR and CD38 coexpression subsets on T lymphocytes during IFN-based chronic hepatitis B treatment.
Lin Y, Shen G, Xie S, Bi X, Lu H, Yang L, Jiang T, Deng W, Wang S, Zhang L, Lu Y, Gao Y, Hao H, Wu S, Liu R, Chang M, Xu M, Hu L, Chen X, Huang R, Li M, Xie Y. Lin Y, et al. Front Immunol. 2023 Jan 24;13:1116160. doi: 10.3389/fimmu.2022.1116160. eCollection 2022. Front Immunol. 2023. PMID: 36761161 Free PMC article.
CONCLUSIONS: The spectrum of HLA-DR and CD38 coexpression subsets on T lymphocytes changed during the long-term treatment of IFN. The establishment of the IFN plateau phase was linked to the persistence of a considerable proportion of HLA …
CONCLUSIONS: The spectrum of HLA-DR and CD38 coexpression subsets on T lymphocytes changed during the long-term …
Differential Elevation of Inflammation and CD4+ T Cell Activation in Kenyan Female Sex Workers and Non-Sex Workers Using Depot-Medroxyprogesterone Acetate.
Omollo K, Lajoie J, Oyugi J, Wessels JM, Mwaengo D, Kimani J, Kaushic C, Fowke KR. Omollo K, et al. Front Immunol. 2021 Feb 23;11:598307. doi: 10.3389/fimmu.2020.598307. eCollection 2020. Front Immunol. 2021. PMID: 33717049 Free PMC article.
Plasma MCP-1, TNFalpha and IL-17 also had reduced expression in FSW not using HC. Non-sex workers using DMPA had elevated proportions of blood-derived CD4(+)CD38(+), CD4(+)CD69(+) and CD4(+)HLA-DR(+) T cells relative to non-sex workers who were …
Plasma MCP-1, TNFalpha and IL-17 also had reduced expression in FSW not using HC. Non-sex workers using DMPA had elevated proportions …
The treatment of psoriasis with IL-10: rationale and review of the first clinical trials.
Asadullah K, Döcke WD, Sabat RV, Volk HD, Sterry W. Asadullah K, et al. Expert Opin Investig Drugs. 2000 Jan;9(1):95-102. doi: 10.1517/13543784.9.1.95. Expert Opin Investig Drugs. 2000. PMID: 11060663 Review.
IL-10 administration over 3 - 7 weeks in patients with moderate to severe psoriasis have supported this hypothesis. The therapy was well-tolerated and clinical efficiency was found in the majority of patients. Immunosuppressive effects (depressed monocytic HLA-DR …
IL-10 administration over 3 - 7 weeks in patients with moderate to severe psoriasis have supported this hypothesis. The therapy was well-tol …
Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab.
Casneuf T, Adams HC 3rd, van de Donk NWCJ, Abraham Y, Bald J, Vanhoof G, Van der Borght K, Smets T, Foulk B, Nielsen KC, Rusbuldt J, Axel A, Lysaght A, Ceulemans H, Stevenaert F, Usmani SZ, Plesner T, Avet-Loiseau H, Nijhof I, Mutis T, Schecter JM, Chiu C, Bahlis NJ. Casneuf T, et al. Leukemia. 2021 Feb;35(2):573-584. doi: 10.1038/s41375-020-0855-4. Epub 2020 May 26. Leukemia. 2021. PMID: 32457357 Free PMC article.
We confirmed previous reports of NK cell reduction with D-Rd. Persisting NK cells were phenotypically distinct, with increased expression of HLA-DR, CD69, CD127, and CD27. The proportion of T cells increased preferentially in deep …
We confirmed previous reports of NK cell reduction with D-Rd. Persisting NK cells were phenotypically distinct, with increased expres …
Neurotrophin-3 attenuates human peripheral blood T cell and monocyte activation status and cytokine production post stroke.
Müller ML, Peglau L, Moon LDF, Groß S, Schulze J, Ruhnau J, Vogelgesang A. Müller ML, et al. Exp Neurol. 2022 Jan;347:113901. doi: 10.1016/j.expneurol.2021.113901. Epub 2021 Oct 22. Exp Neurol. 2022. PMID: 34688600 Free article.
Activation of cells from young humans (without strokes) using anti-CD3/CD28 or LPS partially reduced the proportion of monocytes expressing TrkC whilst they increased the proportion of T cells expressing TrkC. In contrast, activation of cells fr …
Activation of cells from young humans (without strokes) using anti-CD3/CD28 or LPS partially reduced the proportion of monocytes expr …
Comprehensive analysis of the immune pattern of T cell subsets in chronic myeloid leukemia before and after TKI treatment.
Yao D, Lai J, Lu Y, Zhong J, Zha X, Huang X, Liu L, Zeng X, Chen S, Weng J, Du X, Li Y, Xu L. Yao D, et al. Front Immunol. 2023 Jan 19;14:1078118. doi: 10.3389/fimmu.2023.1078118. eCollection 2023. Front Immunol. 2023. PMID: 36742315 Free PMC article.
RESULTS: CD38 or HLA-DR positive PB CD8+TN and TCM cells decreased in the DN-CML patients and this was further decreased in TKI-F patients. Meanwhile, the level of PD-1 elevated in CD8+ TEM and TEMRA cells from PB in all groups. Among BM sample, the level of HLA …
RESULTS: CD38 or HLA-DR positive PB CD8+TN and TCM cells decreased in the DN-CML patients and this was further decreased in TK …
119 results