Combined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia.
Braun TP, Coblentz C, Curtiss BM, Coleman DJ, Schonrock Z, Carratt SA, Callahan RL, Maniaci B, Druker BJ, Maxson JE.
Braun TP, et al.
Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13670-13679. doi: 10.1073/pnas.1918307117. Epub 2020 May 29.
Proc Natl Acad Sci U S A. 2020.
PMID: 32471953
Free PMC article.
Acute myeloid leukemia (AML) is a deadly hematologic malignancy with poor prognosis, particularly in the elderly. ...Mutations in the transcription factor CEBPA are associated with favorable risk in AML. However, mutations in the growth f …
Acute myeloid leukemia (AML) is a deadly hematologic malignancy with poor prognosis, particularly in the …