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Quoted phrase not found in phrase index: "Increased susceptibility to B-cell lymphoma"
Page 1
BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancing regulatory T cell differentiation and cytotoxic T cell exhaustion.
Liu L, Cheng X, Yang H, Lian S, Jiang Y, Liang J, Chen X, Mo S, Shi Y, Zhao S, Li J, Jiang R, Yang DH, Wu Y. Liu L, et al. Mol Cancer. 2022 Feb 22;21(1):59. doi: 10.1186/s12943-022-01516-w. Mol Cancer. 2022. PMID: 35193595 Free PMC article.
BACKGROUND: Chronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not associated with CLL in all patients; therefore, it is important to identify CLL patients with T cell defects. The role of B-cell …
BACKGROUND: Chronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not as …
Immunomodulation and lymphoma in humans.
Ponce RA, Gelzleichter T, Haggerty HG, Heidel S, Holdren MS, Lebrec H, Mellon RD, Pallardy M. Ponce RA, et al. J Immunotoxicol. 2014 Jan-Mar;11(1):1-12. doi: 10.3109/1547691X.2013.798388. Epub 2013 Jun 7. J Immunotoxicol. 2014. PMID: 23746314 Review.
Whereas these models support a role of immune status in many cancers, they are insufficient to explain the disproportionate increase in B-cell lymphoma risk observed across patient populations with either chronic immunosuppression or inflammatio …
Whereas these models support a role of immune status in many cancers, they are insufficient to explain the disproportionate increase …
Genetic and epigenetic determinants of B-cell lymphoma evolution.
Izzo F, Landau DA. Izzo F, et al. Curr Opin Hematol. 2016 Jul;23(4):392-401. doi: 10.1097/MOH.0000000000000258. Curr Opin Hematol. 2016. PMID: 27135978 Review.
PURPOSE OF REVIEW: The success of targeted therapies fostered the development of increasingly specific and effective therapeutics for B-cell malignancies. However, cancer plasticity facilitates disease relapse, whereby intratumoral heterogeneity fuels tumor e …
PURPOSE OF REVIEW: The success of targeted therapies fostered the development of increasingly specific and effective therapeutics for B …
The molecular pathogenesis of B-cell non-Hodgkin lymphoma.
Blombery PA, Wall M, Seymour JF. Blombery PA, et al. Eur J Haematol. 2015 Oct;95(4):280-93. doi: 10.1111/ejh.12589. Epub 2015 Jun 9. Eur J Haematol. 2015. PMID: 25996166 Review.
The B-cell non-Hodgkin lymphomas (B-NHL) are a diverse group of haematological malignancies which arise from the mature B-lymphocyte compartment. ...A paradigm of B-NHL pathogenesis has emerged where the normal genetic processes that are central to generating B …
The B-cell non-Hodgkin lymphomas (B-NHL) are a diverse group of haematological malignancies which arise from the mature B-lymp …
Increased activation of PI3 kinase-delta predisposes to B-cell lymphoma.
Durandy A, Kracker S. Durandy A, et al. Blood. 2020 Feb 27;135(9):638-643. doi: 10.1182/blood.2019002072. Blood. 2020. PMID: 31942637 Free article. Review.
In types 1 and 2 APDS, the PI3K-delta hyperactivity resulting from the gene mutations leads to similar clinical presentations, characterized by increased susceptibility to bacterial and viral infections and (to a lesser extent) autoimmune manifestations. ...A major …
In types 1 and 2 APDS, the PI3K-delta hyperactivity resulting from the gene mutations leads to similar clinical presentations, characterized …
The routes for transformation of follicular lymphoma.
Okosun J, Montoto S, Fitzgibbon J. Okosun J, et al. Curr Opin Hematol. 2016 Jul;23(4):385-91. doi: 10.1097/MOH.0000000000000255. Curr Opin Hematol. 2016. PMID: 27135979 Review.
PURPOSE OF REVIEW: Aggressive transformation, a frequent event in the natural history of follicular lymphoma, is associated with increased lymphoma-related mortality and yet the underlying biology remains poorly defined. ...Although the majority of tFLs maint …
PURPOSE OF REVIEW: Aggressive transformation, a frequent event in the natural history of follicular lymphoma, is associated with i …
The 'omics of obesity in B-cell acute lymphoblastic leukemia.
Geitgey DK, Lee M, Cottrill KA, Jaffe M, Pilcher W, Bhasin S, Randall J, Ross AJ, Salemi M, Castillo-Castrejon M, Kilgore MB, Brown AC, Boss JM, Johnston R, Fitzpatrick AM, Kemp ML, English R, Weaver E, Bagchi P, Walsh R, Scharer CD, Bhasin M, Chandler JD, Haynes KA, Wellberg EA, Henry CJ. Geitgey DK, et al. J Natl Cancer Inst Monogr. 2023 May 4;2023(61):12-29. doi: 10.1093/jncimonographs/lgad014. J Natl Cancer Inst Monogr. 2023. PMID: 37139973 Free PMC article.
We and others have demonstrated that, in the context of B-cell acute lymphoblastic leukemia (B-ALL), adipocytes promote multidrug chemoresistance. ...These analyses revealed that the adipocyte secretome directly modulates programs in human B-ALL cells associated wit …
We and others have demonstrated that, in the context of B-cell acute lymphoblastic leukemia (B-ALL), adipocytes promote multid …
B cells in the pathogenesis of primary Sjögren syndrome.
Nocturne G, Mariette X. Nocturne G, et al. Nat Rev Rheumatol. 2018 Mar;14(3):133-145. doi: 10.1038/nrrheum.2018.1. Epub 2018 Feb 8. Nat Rev Rheumatol. 2018. PMID: 29416129 Review.
Primary Sjogren syndrome (pSS) is a prototypical autoimmune disease. The involvement of B cells in the pathogenesis of pSS has long been suspected on the basis of clinical observations that include the presence of serum autoantibodies, hypergammaglobulinaemia, in …
Primary Sjogren syndrome (pSS) is a prototypical autoimmune disease. The involvement of B cells in the pathogenesis of pSS has long b …
Association of HLA diversity with the risk of 25 cancers in the UK Biobank.
Wang QL, Wang TM, Deng CM, Zhang WL, He YQ, Xue WQ, Liao Y, Yang DW, Zheng MQ, Jia WH. Wang QL, et al. EBioMedicine. 2023 Jun;92:104588. doi: 10.1016/j.ebiom.2023.104588. Epub 2023 May 4. EBioMedicine. 2023. PMID: 37148584 Free PMC article.
Besides, a lower risk of non-Hodgkin lymphoma was associated with an increased diversity of HLA class I (OR(hetero) = 0.92, 95% CI = 0.87-0.98, P = 8.38 10(-3)) and class II locus (OR(hetero) = 0.89, 95% CI = 0.86-0.92, P = 1.65 10(-10)). ...The protective effect of …
Besides, a lower risk of non-Hodgkin lymphoma was associated with an increased diversity of HLA class I (OR(hetero) = 0.92, 95 …
The Role of PI3K Inhibition in Lymphoid Malignancies.
von Keudell G, Moskowitz AJ. von Keudell G, et al. Curr Hematol Malig Rep. 2019 Oct;14(5):405-413. doi: 10.1007/s11899-019-00540-w. Curr Hematol Malig Rep. 2019. PMID: 31359259 Review.
After an initial setback related to increased toxicity including deaths observed in several upfront studies, there has been a resurgence in interest in this pathway following the promising efficacy of second-generation PI3K inhibitors including in patients with T ce …
After an initial setback related to increased toxicity including deaths observed in several upfront studies, there has been a …
188 results