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Quoted phrase not found in phrase index: "Infant Acute Lymphoblastic Leukemia without MLL Gene Rearrangement"
Page 1
The MLL recombinome of acute leukemias in 2017.
Meyer C, Burmeister T, Gröger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-de-Oliveira MS, Barbieri Blunck C, Almeida Lopes B, Zuna J, Trka J, Ballerini P, Lapillonne H, De Braekeleer M, Cazzaniga G, Corral Abascal L, van der Velden VHJ, Delabesse E, Park TS, Oh SH, Silva MLM, Lund-Aho T, Juvonen V, Moore AS, Heidenreich O, Vormoor J, Zerkalenkova E, Olshanskaya Y, Bueno C, Menendez P, Teigler-Schlegel A, Zur Stadt U, Lentes J, Göhring G, Kustanovich A, Aleinikova O, Schäfer BW, Kubetzko S, Madsen HO, Gruhn B, Duarte X, Gameiro P, Lippert E, Bidet A, Cayuela JM, Clappier E, Alonso CN, Zwaan CM, van den Heuvel-Eibrink MM, Izraeli S, Trakhtenbrot L, Archer P, Hancock J, Möricke A, Alten J, Schrappe M, Stanulla M, Strehl S, Attarbaschi A, Dworzak M, Haas OA, Panzer-Grümayer R, Sedék L, Szczepański T, Caye A, Suarez L, Cavé H, Marschalek R. Meyer C, et al. Leukemia. 2018 Feb;32(2):273-284. doi: 10.1038/leu.2017.213. Epub 2017 Jul 13. Leukemia. 2018. PMID: 28701730 Free PMC article.
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. ...We observed an age-dependent breakpoint shift with breakpoints localizing within MLL intron 11 ass …
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced …
The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention?
Mansur MB, Ford AM, Emerenciano M. Mansur MB, et al. Biochim Biophys Acta Rev Cancer. 2017 Dec;1868(2):521-526. doi: 10.1016/j.bbcan.2017.10.005. Epub 2017 Oct 19. Biochim Biophys Acta Rev Cancer. 2017. PMID: 29056538 Review.
Childhood acute lymphoblastic leukaemia (ALL) with MLL rearrangement (MLL-r) is an aggressive disease still associated with a high mortality rate. ...In this context, this mini-review summarizes the available data surrounding MLL-r …
Childhood acute lymphoblastic leukaemia (ALL) with MLL rearrangement (MLL-r) is an aggressive dise …
Identification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics.
Candelli T, Schneider P, Garrido Castro P, Jones LA, Bodewes E, Rockx-Brouwer D, Pieters R, Holstege FCP, Margaritis T, Stam RW. Candelli T, et al. Leukemia. 2022 Jan;36(1):58-67. doi: 10.1038/s41375-021-01341-y. Epub 2021 Jul 24. Leukemia. 2022. PMID: 34304246 Free PMC article.
Infants with MLL-rearranged infant acute lymphoblastic leukemia (MLL-r iALL) undergo intense therapy to counter a highly aggressive malignancy with survival rates of only 30-40%. The majority of patients initially show therapy resp …
Infants with MLL-rearranged infant acute lymphoblastic leukemia (MLL-r iALL) undergo intens …
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R. van der Linden MH, et al. Semin Fetal Neonatal Med. 2012 Aug;17(4):192-195. doi: 10.1016/j.siny.2012.03.003. Epub 2012 Apr 15. Semin Fetal Neonatal Med. 2012. PMID: 22510298 Review.
Leukaemia in neonates (infants <1 month) is rare, whereby neonatal acute myeloid leukaemia (AML) is more frequent than neonatal acute lymphoblastic leukaemia (ALL). ...Congenital infections should be ruled out before diagnosis. Rearrangeme …
Leukaemia in neonates (infants <1 month) is rare, whereby neonatal acute myeloid leukaemia (AML) is more frequent than neon …
Acute lymphoblastic leukemia in infancy.
Silverman LB. Silverman LB. Pediatr Blood Cancer. 2007 Dec;49(7 Suppl):1070-3. doi: 10.1002/pbc.21352. Pediatr Blood Cancer. 2007. PMID: 17943956 Review.
Adverse prognostic factors include the presence of an MLL gene rearrangement (observed in up to 80% of infants with ALL), younger age at diagnosis, high presenting leukocyte counts, and slow early response to therapy. The role of stem cell …
Adverse prognostic factors include the presence of an MLL gene rearrangement (observed in up to 80% of infant …
KMT2A rearranged acute lymphoblastic leukaemia: Unravelling the genomic complexity and heterogeneity of this high-risk disease.
Forgione MO, McClure BJ, Eadie LN, Yeung DT, White DL. Forgione MO, et al. Cancer Lett. 2020 Jan 28;469:410-418. doi: 10.1016/j.canlet.2019.11.005. Epub 2019 Nov 6. Cancer Lett. 2020. PMID: 31705930
KMT2A rearranged (KMT2Ar) acute lymphoblastic leukaemia (ALL) is a high-risk genomic subtype, with long-term survival rates of less than 60% across all age groups. These cases present a complex clinical challenge, with a high incidence in infants, high …
KMT2A rearranged (KMT2Ar) acute lymphoblastic leukaemia (ALL) is a high-risk genomic subtype, with long-term survival r …
Insights from clinical studies into the role of the MLL gene in infant and childhood leukemia.
Chowdhury T, Brady HJ. Chowdhury T, et al. Blood Cells Mol Dis. 2008 Mar-Apr;40(2):192-9. doi: 10.1016/j.bcmd.2007.07.005. Epub 2007 Oct 1. Blood Cells Mol Dis. 2008. PMID: 17905612 Review.
Translocations involving the Mixed Lineage Leukemia (MLL) gene at 11q23 are found in both acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML), but have different prognostic implications depending on the …
Translocations involving the Mixed Lineage Leukemia (MLL) gene at 11q23 are found in both acute lymphoblastic …
Does lineage plasticity enable escape from CAR-T cell therapy? Lessons from MLL-r leukemia.
Liao W, Kohler ME, Fry T, Ernst P. Liao W, et al. Exp Hematol. 2021 Aug;100:1-11. doi: 10.1016/j.exphem.2021.07.002. Epub 2021 Jul 21. Exp Hematol. 2021. PMID: 34298117 Free PMC article. Review.
The clinical success of engineered, CD19-directed chimeric antigen receptor (CAR) T cells in relapsed, refractory B-cell acute lymphoblastic leukemia (B-ALL) has generated great enthusiasm for the use of CAR T cells in patients with cytogenetics that p …
The clinical success of engineered, CD19-directed chimeric antigen receptor (CAR) T cells in relapsed, refractory B-cell acute …
The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia.
Stumpel DJ, Schneider P, Pieters R, Stam RW. Stumpel DJ, et al. Eur J Cancer. 2015 Sep;51(14):2008-21. doi: 10.1016/j.ejca.2015.06.117. Epub 2015 Jul 15. Eur J Cancer. 2015. PMID: 26188848 Free article.
MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most difficult-to-treat type of childhood ALL, displaying a chemotherapy-resistant phenotype, and unique histone modifications, gene expression signatures and DNA methyl …
MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most difficult-to-treat type of chil …
Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia.
Tejedor JR, Bueno C, Vinyoles M, Petazzi P, Agraz-Doblas A, Cobo I, Torres-Ruiz R, Bayón GF, Pérez RF, López-Tamargo S, Gutierrez-Agüera F, Santamarina-Ojeda P, Ramírez-Orellana M, Bardini M, Cazzaniga G, Ballerini P, Schneider P, Stam RW, Varela I, Fraga MF, Fernández AF, Menéndez P. Tejedor JR, et al. J Clin Invest. 2021 Jul 1;131(13):e138833. doi: 10.1172/JCI138833. J Clin Invest. 2021. PMID: 33983906 Free PMC article.
B cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. As predicted by its prenatal origin, infant B-ALL (iB-ALL) shows an exceptionally silent DNA mutational landscape, suggesting that alternative epigenetic mec …
B cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. As predicted by its pren …
68 results